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The stratum corneum barrier – From molecular scale to macroscopic properties

Sparr, Emma LU ; Björklund, Sebastian LU ; Pham, Q. Dat LU ; Mojumdar, Enamul H. LU ; Stenqvist, B. LU ; Gunnarsson, M. LU and Topgaard, D. LU (2023) In Current Opinion in Colloid and Interface Science 67.
Abstract

The upper layer of our skin, the stratum corneum (SC), is a versatile material that combines mechanical strength with efficient barrier function. In this paper, we discuss these macroscopic properties of SC in relation to recent findings on molecular responses and structural diversity in SC protein and lipids. We put particular focus on the intermediate (colloidal) length scale and how the different SC substructures are organized with respect to each other, including effects of non-equilibrium conditions in the skin with respect to the gradients in water and other components.

Please use this url to cite or link to this publication:
author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Fluid and solid lipids, Heterogenous structures, Keratin filaments, Natural moisturizing factor, Skin hydration, Transport routes
in
Current Opinion in Colloid and Interface Science
volume
67
article number
101725
publisher
Elsevier
external identifiers
  • scopus:85167567586
ISSN
1359-0294
DOI
10.1016/j.cocis.2023.101725
language
English
LU publication?
yes
id
b16b1e6e-9837-4fce-9b20-52e4b851a43a
date added to LUP
2023-11-30 13:11:08
date last changed
2023-11-30 13:13:35
@article{b16b1e6e-9837-4fce-9b20-52e4b851a43a,
  abstract     = {{<p>The upper layer of our skin, the stratum corneum (SC), is a versatile material that combines mechanical strength with efficient barrier function. In this paper, we discuss these macroscopic properties of SC in relation to recent findings on molecular responses and structural diversity in SC protein and lipids. We put particular focus on the intermediate (colloidal) length scale and how the different SC substructures are organized with respect to each other, including effects of non-equilibrium conditions in the skin with respect to the gradients in water and other components.</p>}},
  author       = {{Sparr, Emma and Björklund, Sebastian and Pham, Q. Dat and Mojumdar, Enamul H. and Stenqvist, B. and Gunnarsson, M. and Topgaard, D.}},
  issn         = {{1359-0294}},
  keywords     = {{Fluid and solid lipids; Heterogenous structures; Keratin filaments; Natural moisturizing factor; Skin hydration; Transport routes}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{Current Opinion in Colloid and Interface Science}},
  title        = {{The stratum corneum barrier – From molecular scale to macroscopic properties}},
  url          = {{http://dx.doi.org/10.1016/j.cocis.2023.101725}},
  doi          = {{10.1016/j.cocis.2023.101725}},
  volume       = {{67}},
  year         = {{2023}},
}