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Endothelial derived vasoactive factors and leukocyte derived inflammatory mediators in subjects with asymptomatic atherosclerosis

Anwaar, I. ; Gottsater, A. LU ; Hedblad, B. LU ; Palmqvist, B. LU ; Mattiasson, I. LU and Lindgarde, F. LU (1998) In Angiology 49(12). p.957-966
Abstract

To clarify relationships between the (endothelial vasodilatory and vasoconstrictive function) and leukocyte inflammatory mediators in subjects with asymptomatic atherosclerosis, we measured (intraplatelet cyclic 3', 5' guanosine monophosphate [cGMP] and cyclic 3', 5' adenosine monophosphate [cAMP]), plasma endothelin (ET-1), and plasma neopterin in 197 subjects with asymptomatic atherosclerosis (median age 63 years, range 49-69 years). We measured neutrophil protease 4 (NP4), tumor necrosis factor (TNFμ), soluble tumor necrosis factor receptor-1 (sTNFR-1), and neutrophil gelatinase associated lipocalin (NGAL) in 152 of the 197 subjects. Intraplatelet cGMP correlated inversely with plasma ET-1 (r=-0.22; p=0.01), which confirms... (More)

To clarify relationships between the (endothelial vasodilatory and vasoconstrictive function) and leukocyte inflammatory mediators in subjects with asymptomatic atherosclerosis, we measured (intraplatelet cyclic 3', 5' guanosine monophosphate [cGMP] and cyclic 3', 5' adenosine monophosphate [cAMP]), plasma endothelin (ET-1), and plasma neopterin in 197 subjects with asymptomatic atherosclerosis (median age 63 years, range 49-69 years). We measured neutrophil protease 4 (NP4), tumor necrosis factor (TNFμ), soluble tumor necrosis factor receptor-1 (sTNFR-1), and neutrophil gelatinase associated lipocalin (NGAL) in 152 of the 197 subjects. Intraplatelet cGMP correlated inversely with plasma ET-1 (r=-0.22; p=0.01), which confirms earlier in vitro data of the inhibitory effect of ET-1 on NO production and/or the cGMP mediated inhibitory effect of NO on ET-1 production. Plasma neopterin as well as NP4 correlated directly with intraplatelet cGMP (r=0.24; p<0.01 and r=0.33; p<0.001, respectively). Intraplatelet cAMP correlated directly with plasma TNFμ (r=0.17; p<0.05) and sTNFR-1 (r=0.20; p<0.05). The relationship between leukocyte derived inflammatory mediators and intraplatelet cyclic nucleotides suggest an antiaggregating effect of leukocytes upon platelets, which may constitute a negative feedback mechanism that inhibits platelet activation during the atherosclerotic inflammatory process.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Angiology
volume
49
issue
12
pages
10 pages
publisher
SAGE Publications
external identifiers
  • pmid:9855370
  • scopus:0032433248
ISSN
0003-3197
DOI
10.1177/000331979804901201
language
English
LU publication?
yes
id
b16ebb7e-6a84-4525-b913-bca05a563856
date added to LUP
2020-12-11 14:23:21
date last changed
2024-01-03 00:51:57
@article{b16ebb7e-6a84-4525-b913-bca05a563856,
  abstract     = {{<p>To clarify relationships between the (endothelial vasodilatory and vasoconstrictive function) and leukocyte inflammatory mediators in subjects with asymptomatic atherosclerosis, we measured (intraplatelet cyclic 3', 5' guanosine monophosphate [cGMP] and cyclic 3', 5' adenosine monophosphate [cAMP]), plasma endothelin (ET-1), and plasma neopterin in 197 subjects with asymptomatic atherosclerosis (median age 63 years, range 49-69 years). We measured neutrophil protease 4 (NP<sub>4</sub>), tumor necrosis factor (TNFμ), soluble tumor necrosis factor receptor-1 (sTNFR-1), and neutrophil gelatinase associated lipocalin (NGAL) in 152 of the 197 subjects. Intraplatelet cGMP correlated inversely with plasma ET-1 (r=-0.22; p=0.01), which confirms earlier in vitro data of the inhibitory effect of ET-1 on NO production and/or the cGMP mediated inhibitory effect of NO on ET-1 production. Plasma neopterin as well as NP4 correlated directly with intraplatelet cGMP (r=0.24; p&lt;0.01 and r=0.33; p&lt;0.001, respectively). Intraplatelet cAMP correlated directly with plasma TNFμ (r=0.17; p&lt;0.05) and sTNFR-1 (r=0.20; p&lt;0.05). The relationship between leukocyte derived inflammatory mediators and intraplatelet cyclic nucleotides suggest an antiaggregating effect of leukocytes upon platelets, which may constitute a negative feedback mechanism that inhibits platelet activation during the atherosclerotic inflammatory process.</p>}},
  author       = {{Anwaar, I. and Gottsater, A. and Hedblad, B. and Palmqvist, B. and Mattiasson, I. and Lindgarde, F.}},
  issn         = {{0003-3197}},
  language     = {{eng}},
  number       = {{12}},
  pages        = {{957--966}},
  publisher    = {{SAGE Publications}},
  series       = {{Angiology}},
  title        = {{Endothelial derived vasoactive factors and leukocyte derived inflammatory mediators in subjects with asymptomatic atherosclerosis}},
  url          = {{http://dx.doi.org/10.1177/000331979804901201}},
  doi          = {{10.1177/000331979804901201}},
  volume       = {{49}},
  year         = {{1998}},
}