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Atrial fibrosis : An obligatory component of arrhythmia mechanisms in atrial fibrillation?

Platonov, Pyotr G. LU (2017) In Journal of Geriatric Cardiology 14(4). p.233-237
Abstract

Atrial fibrosis is common in atrial fibrillation (AF). Experimental studies have provided convincing evidence that fibrotic transformation of atrial myocardium results in deterioration of atrial conduction, increasing anisotropy of impulse propagation and building of boundaries that promote re-entry in the atrial walls that maybe directly relevant for the mechanisms responsible for maintaining AF. Whether or not fibrosis is a result of structural remodelling caused by persistent AF or a manifestation of occult myocardial process that leads to development of arrhythmia is less clear. Human data indicate the presence of association between persistency of AF and the extent of structural changes in atrial myocardium. The role atrial... (More)

Atrial fibrosis is common in atrial fibrillation (AF). Experimental studies have provided convincing evidence that fibrotic transformation of atrial myocardium results in deterioration of atrial conduction, increasing anisotropy of impulse propagation and building of boundaries that promote re-entry in the atrial walls that maybe directly relevant for the mechanisms responsible for maintaining AF. Whether or not fibrosis is a result of structural remodelling caused by persistent AF or a manifestation of occult myocardial process that leads to development of arrhythmia is less clear. Human data indicate the presence of association between persistency of AF and the extent of structural changes in atrial myocardium. The role atrial fibrosis plays in the mechanisms of AF, however, may differ between patients with structurally normal hearts, such as lone AF, and those with advanced cardiovascular comorbidities.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Atrial fibrillation, Fibrosis, Remodeling
in
Journal of Geriatric Cardiology
volume
14
issue
4
pages
5 pages
publisher
Science Press
external identifiers
  • scopus:85020860566
  • wos:000413836500002
ISSN
1671-5411
DOI
10.11909/j.issn.1671-5411.2017.04.008
language
English
LU publication?
yes
id
b1895d92-a112-4d90-8b58-5bbb12f510aa
date added to LUP
2017-08-22 11:41:02
date last changed
2018-01-16 13:23:11
@article{b1895d92-a112-4d90-8b58-5bbb12f510aa,
  abstract     = {<p>Atrial fibrosis is common in atrial fibrillation (AF). Experimental studies have provided convincing evidence that fibrotic transformation of atrial myocardium results in deterioration of atrial conduction, increasing anisotropy of impulse propagation and building of boundaries that promote re-entry in the atrial walls that maybe directly relevant for the mechanisms responsible for maintaining AF. Whether or not fibrosis is a result of structural remodelling caused by persistent AF or a manifestation of occult myocardial process that leads to development of arrhythmia is less clear. Human data indicate the presence of association between persistency of AF and the extent of structural changes in atrial myocardium. The role atrial fibrosis plays in the mechanisms of AF, however, may differ between patients with structurally normal hearts, such as lone AF, and those with advanced cardiovascular comorbidities.</p>},
  author       = {Platonov, Pyotr G.},
  issn         = {1671-5411},
  keyword      = {Atrial fibrillation,Fibrosis,Remodeling},
  language     = {eng},
  number       = {4},
  pages        = {233--237},
  publisher    = {Science Press},
  series       = {Journal of Geriatric Cardiology},
  title        = {Atrial fibrosis : An obligatory component of arrhythmia mechanisms in atrial fibrillation?},
  url          = {http://dx.doi.org/10.11909/j.issn.1671-5411.2017.04.008},
  volume       = {14},
  year         = {2017},
}