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Human cancer, the naked mole rat and faunal turnovers

Bredberg, Anders LU and Schmitz, Birger LU (2019) In Cancer Medicine 8(4). p.1652-1654
Abstract

We argue that the human evolutionary heritage with frequent adaptations through geological time to environmental change has affected a trade-off between offspring variability and cancer resistance, and thus favored cancer-prone individuals. We turn the attention to a factor setting the highly cancer-resistant naked mole rat apart from most other mammals: it has remained phenotypically largely unchanged since 30-50 million years ago. Research focusing on DNA stability mechanisms in ‘living fossil’ animals may help us find tools for cancer prevention and treatment.

Please use this url to cite or link to this publication:
author
and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cancer resistance, Cretaceous-Paleogene boundary, Heterocephalus glaber, human cancer excess, human mutation rate, naked mole rat, Peto's paradox, rapid human evolution
in
Cancer Medicine
volume
8
issue
4
pages
3 pages
publisher
Wiley-Blackwell
external identifiers
  • pmid:30790458
  • scopus:85065078389
ISSN
2045-7634
DOI
10.1002/cam4.2011
language
English
LU publication?
yes
id
b190fee2-b8cb-470b-8265-2da851276a58
date added to LUP
2019-05-16 09:33:00
date last changed
2024-04-16 05:42:01
@article{b190fee2-b8cb-470b-8265-2da851276a58,
  abstract     = {{<p>We argue that the human evolutionary heritage with frequent adaptations through geological time to environmental change has affected a trade-off between offspring variability and cancer resistance, and thus favored cancer-prone individuals. We turn the attention to a factor setting the highly cancer-resistant naked mole rat apart from most other mammals: it has remained phenotypically largely unchanged since 30-50 million years ago. Research focusing on DNA stability mechanisms in ‘living fossil’ animals may help us find tools for cancer prevention and treatment.</p>}},
  author       = {{Bredberg, Anders and Schmitz, Birger}},
  issn         = {{2045-7634}},
  keywords     = {{cancer resistance; Cretaceous-Paleogene boundary; Heterocephalus glaber; human cancer excess; human mutation rate; naked mole rat; Peto's paradox; rapid human evolution}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{1652--1654}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Cancer Medicine}},
  title        = {{Human cancer, the naked mole rat and faunal turnovers}},
  url          = {{http://dx.doi.org/10.1002/cam4.2011}},
  doi          = {{10.1002/cam4.2011}},
  volume       = {{8}},
  year         = {{2019}},
}