Human cancer, the naked mole rat and faunal turnovers
(2019) In Cancer Medicine 8(4). p.1652-1654- Abstract
We argue that the human evolutionary heritage with frequent adaptations through geological time to environmental change has affected a trade-off between offspring variability and cancer resistance, and thus favored cancer-prone individuals. We turn the attention to a factor setting the highly cancer-resistant naked mole rat apart from most other mammals: it has remained phenotypically largely unchanged since 30-50 million years ago. Research focusing on DNA stability mechanisms in ‘living fossil’ animals may help us find tools for cancer prevention and treatment.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/b190fee2-b8cb-470b-8265-2da851276a58
- author
- Bredberg, Anders LU and Schmitz, Birger LU
- organization
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- cancer resistance, Cretaceous-Paleogene boundary, Heterocephalus glaber, human cancer excess, human mutation rate, naked mole rat, Peto's paradox, rapid human evolution
- in
- Cancer Medicine
- volume
- 8
- issue
- 4
- pages
- 3 pages
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:85065078389
- pmid:30790458
- ISSN
- 2045-7634
- DOI
- 10.1002/cam4.2011
- language
- English
- LU publication?
- yes
- id
- b190fee2-b8cb-470b-8265-2da851276a58
- date added to LUP
- 2019-05-16 09:33:00
- date last changed
- 2024-07-09 12:58:46
@article{b190fee2-b8cb-470b-8265-2da851276a58, abstract = {{<p>We argue that the human evolutionary heritage with frequent adaptations through geological time to environmental change has affected a trade-off between offspring variability and cancer resistance, and thus favored cancer-prone individuals. We turn the attention to a factor setting the highly cancer-resistant naked mole rat apart from most other mammals: it has remained phenotypically largely unchanged since 30-50 million years ago. Research focusing on DNA stability mechanisms in ‘living fossil’ animals may help us find tools for cancer prevention and treatment.</p>}}, author = {{Bredberg, Anders and Schmitz, Birger}}, issn = {{2045-7634}}, keywords = {{cancer resistance; Cretaceous-Paleogene boundary; Heterocephalus glaber; human cancer excess; human mutation rate; naked mole rat; Peto's paradox; rapid human evolution}}, language = {{eng}}, number = {{4}}, pages = {{1652--1654}}, publisher = {{Wiley-Blackwell}}, series = {{Cancer Medicine}}, title = {{Human cancer, the naked mole rat and faunal turnovers}}, url = {{http://dx.doi.org/10.1002/cam4.2011}}, doi = {{10.1002/cam4.2011}}, volume = {{8}}, year = {{2019}}, }