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Trapping of Cell-Laden Hyaluronic Acid-Acrylamide Hydrogel Droplets using Bulk Acoustic Waves

Fornell, Anna LU ; Johannesson, Carl LU ; Searle, Sean S. ; Happstadius, Axel ; Nilsson, Johan LU and Tenje, Maria LU (2019) p.2352-2355
Abstract

In this paper an acoustofluidic system to trap hydrogel droplets is shown. The presented trapping method is label-free, biocompatible and operated in non-contact mode. The results show that the droplets can be trapped at flow rates up to 76 μL/min which corresponds to an average flow speed of 3.2 mm/s. Moreover, it is shown that the droplets can be trapped for several hours, thus allowing for studies of the encapsulated cells over time. An application of the system is shown by performing on-chip cell nuclei staining.

Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Acoustofluidics, droplet microfluidics, hydrogels, particle manipulation
host publication
2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII
article number
8808393
pages
4 pages
publisher
Institute of Electrical and Electronics Engineers Inc.
external identifiers
  • scopus:85071925615
ISBN
9781728120072
DOI
10.1109/TRANSDUCERS.2019.8808393
language
English
LU publication?
yes
id
b195cf1f-5d6d-40bc-989b-c389e55cf777
date added to LUP
2019-09-23 08:58:33
date last changed
2019-10-15 07:16:55
@inproceedings{b195cf1f-5d6d-40bc-989b-c389e55cf777,
  abstract     = {<p>In this paper an acoustofluidic system to trap hydrogel droplets is shown. The presented trapping method is label-free, biocompatible and operated in non-contact mode. The results show that the droplets can be trapped at flow rates up to 76 μL/min which corresponds to an average flow speed of 3.2 mm/s. Moreover, it is shown that the droplets can be trapped for several hours, thus allowing for studies of the encapsulated cells over time. An application of the system is shown by performing on-chip cell nuclei staining.</p>},
  author       = {Fornell, Anna and Johannesson, Carl and Searle, Sean S. and Happstadius, Axel and Nilsson, Johan and Tenje, Maria},
  booktitle    = {2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII},
  isbn         = {9781728120072},
  language     = {eng},
  pages        = {2352--2355},
  publisher    = {Institute of Electrical and Electronics Engineers Inc.},
  title        = {Trapping of Cell-Laden Hyaluronic Acid-Acrylamide Hydrogel Droplets using Bulk Acoustic Waves},
  url          = {http://dx.doi.org/10.1109/TRANSDUCERS.2019.8808393},
  doi          = {10.1109/TRANSDUCERS.2019.8808393},
  year         = {2019},
}