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Trapping of Cell-Laden Hyaluronic Acid-Acrylamide Hydrogel Droplets using Bulk Acoustic Waves

Fornell, Anna LU ; Johannesson, Carl LU ; Searle, Sean S. ; Happstadius, Axel ; Nilsson, Johan LU and Tenje, Maria LU (2019) 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII p.2352-2355
Abstract

In this paper an acoustofluidic system to trap hydrogel droplets is shown. The presented trapping method is label-free, biocompatible and operated in non-contact mode. The results show that the droplets can be trapped at flow rates up to 76 μL/min which corresponds to an average flow speed of 3.2 mm/s. Moreover, it is shown that the droplets can be trapped for several hours, thus allowing for studies of the encapsulated cells over time. An application of the system is shown by performing on-chip cell nuclei staining.

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author
; ; ; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Acoustofluidics, droplet microfluidics, hydrogels, particle manipulation
host publication
2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII
article number
8808393
pages
4 pages
publisher
IEEE - Institute of Electrical and Electronics Engineers Inc.
conference name
20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII
conference location
Berlin, Germany
conference dates
2019-06-23 - 2019-06-27
external identifiers
  • scopus:85071925615
ISBN
9781728120072
DOI
10.1109/TRANSDUCERS.2019.8808393
language
English
LU publication?
yes
id
b195cf1f-5d6d-40bc-989b-c389e55cf777
date added to LUP
2019-09-23 08:58:33
date last changed
2023-10-21 20:24:51
@inproceedings{b195cf1f-5d6d-40bc-989b-c389e55cf777,
  abstract     = {{<p>In this paper an acoustofluidic system to trap hydrogel droplets is shown. The presented trapping method is label-free, biocompatible and operated in non-contact mode. The results show that the droplets can be trapped at flow rates up to 76 μL/min which corresponds to an average flow speed of 3.2 mm/s. Moreover, it is shown that the droplets can be trapped for several hours, thus allowing for studies of the encapsulated cells over time. An application of the system is shown by performing on-chip cell nuclei staining.</p>}},
  author       = {{Fornell, Anna and Johannesson, Carl and Searle, Sean S. and Happstadius, Axel and Nilsson, Johan and Tenje, Maria}},
  booktitle    = {{2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII}},
  isbn         = {{9781728120072}},
  keywords     = {{Acoustofluidics; droplet microfluidics; hydrogels; particle manipulation}},
  language     = {{eng}},
  pages        = {{2352--2355}},
  publisher    = {{IEEE - Institute of Electrical and Electronics Engineers Inc.}},
  title        = {{Trapping of Cell-Laden Hyaluronic Acid-Acrylamide Hydrogel Droplets using Bulk Acoustic Waves}},
  url          = {{http://dx.doi.org/10.1109/TRANSDUCERS.2019.8808393}},
  doi          = {{10.1109/TRANSDUCERS.2019.8808393}},
  year         = {{2019}},
}