Risks of depression, anxiety, and suicide in partners of men with prostate cancer : a national cohort study
(2024) In Journal of the National Cancer Institute 116(5). p.745-752- Abstract
Background: A diagnosis of prostate cancer (PC) may cause psychosocial distress not only in a man but also in his intimate partner. However, long-term risks of depression, anxiety, or suicide in partners of men with PC are largely unknown. Methods: A national cohort study was conducted of 121 530 partners of men diagnosed with PC during 1998-2017 and 1 093 304 population-based controls in Sweden. Major depression, anxiety disorder, and suicide death were ascertained through 2018. Cox regression was used to compute hazard ratios (HRs) while adjusting for sociodemographic factors. Results: Partners of men with high-risk PC had increased risks of major depression (adjusted HR ¼ 1.34, 95% confidence interval [CI] ¼ 1.30 to 1.39) and anxiety... (More)
Background: A diagnosis of prostate cancer (PC) may cause psychosocial distress not only in a man but also in his intimate partner. However, long-term risks of depression, anxiety, or suicide in partners of men with PC are largely unknown. Methods: A national cohort study was conducted of 121 530 partners of men diagnosed with PC during 1998-2017 and 1 093 304 population-based controls in Sweden. Major depression, anxiety disorder, and suicide death were ascertained through 2018. Cox regression was used to compute hazard ratios (HRs) while adjusting for sociodemographic factors. Results: Partners of men with high-risk PC had increased risks of major depression (adjusted HR ¼ 1.34, 95% confidence interval [CI] ¼ 1.30 to 1.39) and anxiety disorder (adjusted HR ¼ 1.25, 95% CI ¼ 1.20 to 1.30), which remained elevated 10 or more years later. Suicide death was increased in partners of men with distant metastases (adjusted HR ¼ 2.38, 95% CI ¼ 1.08 to 5.22) but not other high-risk PC (adjusted HR ¼1.14, 95% CI ¼ 0.70 to 1.88). Among partners of men with high-risk PC, risks of major depression and anxiety disorder were highest among those 80 years of age or older (adjusted HR ¼ 1.73; 95% CI ¼ 1.53 to 1.96; adjusted HR ¼ 1.70, 95% CI ¼ 1.47 to 1.96, respectively), whereas suicide death was highest among those younger than 60 years of age (adjusted HR ¼ 7.55, 95% CI ¼ 2.20 to 25.89). In contrast, partners of men with low- or intermediate-risk PC had modestly or no increased risks of these outcomes. Conclusions: In this large cohort, partners of men with high-risk PC had increased risks of major depression and anxiety disorder, which persisted for 10 or more years. Suicide death was increased 2-fold in partners of men with distant metastases. Partners as well as men with PC need psychosocial support and close follow-up for psychosocial distress.
(Less)
- author
- Crump, Casey LU ; Stattin, Par ; Brooks, James D. ; Sundquist, Jan LU ; Edwards, Alexis C. ; Sundquist, Kristina LU and Sieh, Weiva
- organization
- publishing date
- 2024-05-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of the National Cancer Institute
- volume
- 116
- issue
- 5
- pages
- 8 pages
- publisher
- Oxford University Press
- external identifiers
-
- scopus:85192671269
- pmid:38060258
- ISSN
- 0027-8874
- DOI
- 10.1093/jnci/djad257
- language
- English
- LU publication?
- yes
- id
- b19cc7e9-17a4-4a3e-b4f4-f4b52fad3739
- date added to LUP
- 2024-05-23 13:50:07
- date last changed
- 2024-06-20 15:37:03
@article{b19cc7e9-17a4-4a3e-b4f4-f4b52fad3739,
abstract = {{<p>Background: A diagnosis of prostate cancer (PC) may cause psychosocial distress not only in a man but also in his intimate partner. However, long-term risks of depression, anxiety, or suicide in partners of men with PC are largely unknown. Methods: A national cohort study was conducted of 121 530 partners of men diagnosed with PC during 1998-2017 and 1 093 304 population-based controls in Sweden. Major depression, anxiety disorder, and suicide death were ascertained through 2018. Cox regression was used to compute hazard ratios (HRs) while adjusting for sociodemographic factors. Results: Partners of men with high-risk PC had increased risks of major depression (adjusted HR ¼ 1.34, 95% confidence interval [CI] ¼ 1.30 to 1.39) and anxiety disorder (adjusted HR ¼ 1.25, 95% CI ¼ 1.20 to 1.30), which remained elevated 10 or more years later. Suicide death was increased in partners of men with distant metastases (adjusted HR ¼ 2.38, 95% CI ¼ 1.08 to 5.22) but not other high-risk PC (adjusted HR ¼1.14, 95% CI ¼ 0.70 to 1.88). Among partners of men with high-risk PC, risks of major depression and anxiety disorder were highest among those 80 years of age or older (adjusted HR ¼ 1.73; 95% CI ¼ 1.53 to 1.96; adjusted HR ¼ 1.70, 95% CI ¼ 1.47 to 1.96, respectively), whereas suicide death was highest among those younger than 60 years of age (adjusted HR ¼ 7.55, 95% CI ¼ 2.20 to 25.89). In contrast, partners of men with low- or intermediate-risk PC had modestly or no increased risks of these outcomes. Conclusions: In this large cohort, partners of men with high-risk PC had increased risks of major depression and anxiety disorder, which persisted for 10 or more years. Suicide death was increased 2-fold in partners of men with distant metastases. Partners as well as men with PC need psychosocial support and close follow-up for psychosocial distress.</p>}},
author = {{Crump, Casey and Stattin, Par and Brooks, James D. and Sundquist, Jan and Edwards, Alexis C. and Sundquist, Kristina and Sieh, Weiva}},
issn = {{0027-8874}},
language = {{eng}},
month = {{05}},
number = {{5}},
pages = {{745--752}},
publisher = {{Oxford University Press}},
series = {{Journal of the National Cancer Institute}},
title = {{Risks of depression, anxiety, and suicide in partners of men with prostate cancer : a national cohort study}},
url = {{http://dx.doi.org/10.1093/jnci/djad257}},
doi = {{10.1093/jnci/djad257}},
volume = {{116}},
year = {{2024}},
}