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Novel Assay of Metformin Levels in Patients With Type 2 Diabetes and Varying Levels of Renal Function Clinical recommendations

Frid, Anders LU ; Sterner, Gunnar LU ; Löndahl, Magnus LU ; Wiklander, Clara ; Cato, Anne ; Vinge, Ellen LU and Andersson, Anders S LU (2010) In Diabetes Care 33(6). p.1291-1293
Abstract
AbstractObjective: To study trough levels of metformin in serum and its intra individual variation in patients using a newly developed assay. Research Design and Methods: Trough serum levels of metformin was measured once using Liquid Chromatography Tandem Mass Spectrometry (LcMSMS) in 137 type 2 diabetes patients with varying renal function (99 men) and followed repeatedly during two months in 20 patients (16 men) with estimated GFR (eGFR) below 60 ml/min/1.73 m(2) body surface. Results: Patients with eGFR >60, 30-60, and <30 ml/min/1.73 m(2) had a median trough metformin concentration of 4.5 mumol/l (range 0.1-20.7, n=107), 7.71 mumol/l (0.12-15.15, n=21), and 8.88 mumol/l (5.99-18.60, n=9), respectively. The median intraindividual... (More)
AbstractObjective: To study trough levels of metformin in serum and its intra individual variation in patients using a newly developed assay. Research Design and Methods: Trough serum levels of metformin was measured once using Liquid Chromatography Tandem Mass Spectrometry (LcMSMS) in 137 type 2 diabetes patients with varying renal function (99 men) and followed repeatedly during two months in 20 patients (16 men) with estimated GFR (eGFR) below 60 ml/min/1.73 m(2) body surface. Results: Patients with eGFR >60, 30-60, and <30 ml/min/1.73 m(2) had a median trough metformin concentration of 4.5 mumol/l (range 0.1-20.7, n=107), 7.71 mumol/l (0.12-15.15, n=21), and 8.88 mumol/l (5.99-18.60, n=9), respectively. The median intraindividual overall coefficient of variation (CV) was 29.4 % (range 9,8-74,2). Conclusions: Determination of serum metformin with the LCMSMS technique is useful in patients on metformin treatment. Few patients had values over 20 mumol/L. Metformin measurement is less suitable for dose titration. (Less)
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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetes Care
volume
33
issue
6
pages
1291 - 1293
publisher
American Diabetes Association
external identifiers
  • wos:000279304300027
  • pmid:20215446
  • scopus:77956065470
  • pmid:20215446
ISSN
1935-5548
DOI
10.2337/dc09-1284
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pediatrics/Urology/Gynecology/Endocrinology (013240400), Internal Medicine Research Unit (013242520), Medicine (Lund) (013230025), Division of Clinical Chemistry and Pharmacology (013250300)
id
b1ad1da8-1375-4ae1-aa14-102b7698462e (old id 1582365)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20215446?dopt=Abstract
date added to LUP
2016-04-01 10:35:35
date last changed
2024-02-21 20:17:13
@article{b1ad1da8-1375-4ae1-aa14-102b7698462e,
  abstract     = {{AbstractObjective: To study trough levels of metformin in serum and its intra individual variation in patients using a newly developed assay. Research Design and Methods: Trough serum levels of metformin was measured once using Liquid Chromatography Tandem Mass Spectrometry (LcMSMS) in 137 type 2 diabetes patients with varying renal function (99 men) and followed repeatedly during two months in 20 patients (16 men) with estimated GFR (eGFR) below 60 ml/min/1.73 m(2) body surface. Results: Patients with eGFR &gt;60, 30-60, and &lt;30 ml/min/1.73 m(2) had a median trough metformin concentration of 4.5 mumol/l (range 0.1-20.7, n=107), 7.71 mumol/l (0.12-15.15, n=21), and 8.88 mumol/l (5.99-18.60, n=9), respectively. The median intraindividual overall coefficient of variation (CV) was 29.4 % (range 9,8-74,2). Conclusions: Determination of serum metformin with the LCMSMS technique is useful in patients on metformin treatment. Few patients had values over 20 mumol/L. Metformin measurement is less suitable for dose titration.}},
  author       = {{Frid, Anders and Sterner, Gunnar and Löndahl, Magnus and Wiklander, Clara and Cato, Anne and Vinge, Ellen and Andersson, Anders S}},
  issn         = {{1935-5548}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{1291--1293}},
  publisher    = {{American Diabetes Association}},
  series       = {{Diabetes Care}},
  title        = {{Novel Assay of Metformin Levels in Patients With Type 2 Diabetes and Varying Levels of Renal Function Clinical recommendations}},
  url          = {{http://dx.doi.org/10.2337/dc09-1284}},
  doi          = {{10.2337/dc09-1284}},
  volume       = {{33}},
  year         = {{2010}},
}