Most gene fusions in cancer are stochastic events
(2019) In Genes Chromosomes and Cancer 58(9). p.607-611- Abstract
Cancer-associated gene fusions resulting in chimeric proteins or aberrant expression of one or both partner genes are pathogenetically and clinically important in several hematologic malignancies and solid tumors. Since the advent of different types of massively parallel sequencing (MPS), the number of identified gene fusions has increased dramatically, prompting the question whether they all have a biologic impact. By ascertaining the chromosomal locations of 8934 genes involved in 10 861 gene fusions reported in the literature, we here show that there is a highly significant association between gene content of chromosomes and chromosome bands and number of genes involved in fusions. This strongly suggests that a clear majority of gene... (More)
Cancer-associated gene fusions resulting in chimeric proteins or aberrant expression of one or both partner genes are pathogenetically and clinically important in several hematologic malignancies and solid tumors. Since the advent of different types of massively parallel sequencing (MPS), the number of identified gene fusions has increased dramatically, prompting the question whether they all have a biologic impact. By ascertaining the chromosomal locations of 8934 genes involved in 10 861 gene fusions reported in the literature, we here show that there is a highly significant association between gene content of chromosomes and chromosome bands and number of genes involved in fusions. This strongly suggests that a clear majority of gene fusions detected by MPS are stochastic events associated with the number of genes available to participate in fusions and that most reported gene fusions are passengers without any pathogenetic importance.
(Less)
- author
- Johansson, Bertil LU ; Mertens, Fredrik LU ; Schyman, Tommy ; Björk, Jonas LU ; Mandahl, Nils LU and Mitelman, Felix LU
- organization
-
- Genetic and epigenetic studies of pediatric leukemia (research group)
- Division of Clinical Genetics
- BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
- The genetics of soft tissue tumors (research group)
- EPI@LUND (research group)
- Surgery and public health (research group)
- eSSENCE: The e-Science Collaboration
- Division of Occupational and Environmental Medicine, Lund University
- EpiHealth: Epidemiology for Health
- publishing date
- 2019-09
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- cancer, chromosome bands, chromosomes, gene content, gene fusions
- in
- Genes Chromosomes and Cancer
- volume
- 58
- issue
- 9
- pages
- 5 pages
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- scopus:85068471176
- pmid:30807681
- ISSN
- 1045-2257
- DOI
- 10.1002/gcc.22745
- language
- English
- LU publication?
- yes
- id
- b1e39a1c-74af-4d6f-b9f9-6266b852fad6
- date added to LUP
- 2019-07-16 09:39:26
- date last changed
- 2024-09-19 06:17:01
@article{b1e39a1c-74af-4d6f-b9f9-6266b852fad6, abstract = {{<p>Cancer-associated gene fusions resulting in chimeric proteins or aberrant expression of one or both partner genes are pathogenetically and clinically important in several hematologic malignancies and solid tumors. Since the advent of different types of massively parallel sequencing (MPS), the number of identified gene fusions has increased dramatically, prompting the question whether they all have a biologic impact. By ascertaining the chromosomal locations of 8934 genes involved in 10 861 gene fusions reported in the literature, we here show that there is a highly significant association between gene content of chromosomes and chromosome bands and number of genes involved in fusions. This strongly suggests that a clear majority of gene fusions detected by MPS are stochastic events associated with the number of genes available to participate in fusions and that most reported gene fusions are passengers without any pathogenetic importance.</p>}}, author = {{Johansson, Bertil and Mertens, Fredrik and Schyman, Tommy and Björk, Jonas and Mandahl, Nils and Mitelman, Felix}}, issn = {{1045-2257}}, keywords = {{cancer; chromosome bands; chromosomes; gene content; gene fusions}}, language = {{eng}}, number = {{9}}, pages = {{607--611}}, publisher = {{John Wiley & Sons Inc.}}, series = {{Genes Chromosomes and Cancer}}, title = {{Most gene fusions in cancer are stochastic events}}, url = {{http://dx.doi.org/10.1002/gcc.22745}}, doi = {{10.1002/gcc.22745}}, volume = {{58}}, year = {{2019}}, }