High Levels of Endothelin (ET)-1 and Aneurysm Diameter Independently Predict Growth of Stable Abdominal Aortic Aneurysms
(2010) In Angiology 61(4). p.324-328- Abstract
- The etiology of abdominal aortic aneurysm (AAA) includes inflammation and endothelial dysfunction. To evaluate relations between these mechanisms and AAA growth, endothelin (ET)-1, tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and CD40 ligand were related to yearly AAA growth for 2.9 +/- 1.6 years (mean +/- SD) in 178 patients with conservatively followed AAA. Total number of follow-up years was 491. Abdominal aortic aneurysm diameter increased by 3.3 +/- 4.0 mm during the first year and by 4.9 +/- 4.4 mm during the first 2 years. Median (range) growth was 2.5 (-1.0 to 30.6) mm/year. When patients with AAA growth above or below median were compared, initial AAA diameter (46.1 +/- 5.8 vs 42.0 +/- 8.3 mm; P < .0001), age (75 +/-... (More)
- The etiology of abdominal aortic aneurysm (AAA) includes inflammation and endothelial dysfunction. To evaluate relations between these mechanisms and AAA growth, endothelin (ET)-1, tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and CD40 ligand were related to yearly AAA growth for 2.9 +/- 1.6 years (mean +/- SD) in 178 patients with conservatively followed AAA. Total number of follow-up years was 491. Abdominal aortic aneurysm diameter increased by 3.3 +/- 4.0 mm during the first year and by 4.9 +/- 4.4 mm during the first 2 years. Median (range) growth was 2.5 (-1.0 to 30.6) mm/year. When patients with AAA growth above or below median were compared, initial AAA diameter (46.1 +/- 5.8 vs 42.0 +/- 8.3 mm; P < .0001), age (75 +/- 7 vs 72 +/- 8 years; P < .029), and initial ET-1 levels (1.31 +/- 0.50 vs 1.13 +/- 0.49 pg/mL; P <.0177) were higher in patients with growth above median. Endothelin 1 (P = .0230) and initial AAA diameter (P = .0019) predicted AAA growth above median in logistic regression. In conclusion, higher initial levels of ET-1 and initial AAA diameter independently predict AAA growth. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1601922
- author
- Flondell-Sité, Despina LU ; Lindblad, Bengt LU and Gottsäter, Anders LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- tumor necrosis factor alpha, inflammation, statin, endothelin 1, abdominal aortic aneurysm, growth, interleukin 6, CD40 ligand
- in
- Angiology
- volume
- 61
- issue
- 4
- pages
- 324 - 328
- publisher
- SAGE Publications
- external identifiers
-
- wos:000276897300002
- scopus:77952710858
- pmid:19689995
- ISSN
- 0003-3197
- DOI
- 10.1177/0003319709344190
- language
- English
- LU publication?
- yes
- id
- b2163164-2da7-4426-b2e3-e010be3dce24 (old id 1601922)
- date added to LUP
- 2016-04-01 13:49:18
- date last changed
- 2024-02-12 08:17:17
@article{b2163164-2da7-4426-b2e3-e010be3dce24, abstract = {{The etiology of abdominal aortic aneurysm (AAA) includes inflammation and endothelial dysfunction. To evaluate relations between these mechanisms and AAA growth, endothelin (ET)-1, tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and CD40 ligand were related to yearly AAA growth for 2.9 +/- 1.6 years (mean +/- SD) in 178 patients with conservatively followed AAA. Total number of follow-up years was 491. Abdominal aortic aneurysm diameter increased by 3.3 +/- 4.0 mm during the first year and by 4.9 +/- 4.4 mm during the first 2 years. Median (range) growth was 2.5 (-1.0 to 30.6) mm/year. When patients with AAA growth above or below median were compared, initial AAA diameter (46.1 +/- 5.8 vs 42.0 +/- 8.3 mm; P < .0001), age (75 +/- 7 vs 72 +/- 8 years; P < .029), and initial ET-1 levels (1.31 +/- 0.50 vs 1.13 +/- 0.49 pg/mL; P <.0177) were higher in patients with growth above median. Endothelin 1 (P = .0230) and initial AAA diameter (P = .0019) predicted AAA growth above median in logistic regression. In conclusion, higher initial levels of ET-1 and initial AAA diameter independently predict AAA growth.}}, author = {{Flondell-Sité, Despina and Lindblad, Bengt and Gottsäter, Anders}}, issn = {{0003-3197}}, keywords = {{tumor necrosis factor alpha; inflammation; statin; endothelin 1; abdominal aortic aneurysm; growth; interleukin 6; CD40 ligand}}, language = {{eng}}, number = {{4}}, pages = {{324--328}}, publisher = {{SAGE Publications}}, series = {{Angiology}}, title = {{High Levels of Endothelin (ET)-1 and Aneurysm Diameter Independently Predict Growth of Stable Abdominal Aortic Aneurysms}}, url = {{http://dx.doi.org/10.1177/0003319709344190}}, doi = {{10.1177/0003319709344190}}, volume = {{61}}, year = {{2010}}, }