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Difference in the risk profiles of carotid-femoral pulse wave velocity : results from two community-based studies in China and Sweden

Guo, Qian Hui LU ; Muhammad, Iram Faqir LU ; Borné, Yan LU ; Sheng, Chang Sheng; Persson, Margaretha LU ; Wang, Ji Guang; Engström, Gunnar LU ; Li, Yan and Nilsson, Peter M. LU (2019) In Journal of Human Hypertension
Abstract

Carotid-femoral pulse wave velocity (cfPWV) and its risk factors may differ between various populations. Few studies have compared the risk profiles associated with cfPWV in different ethnic populations. The study population included 4321 subjects from Shanghai, China (n = 1272, age 75.0 ± 6.5 years, female 57.3%) and Malmö, Sweden (n = 3049, age 72.5 ± 5.5 years, female 60.4%). cfPWV was measured using the SphygmoCor device in both cohorts, with some difference in the determination of pulse transmission distance. The median cfPWV was 8.9 and 10.1 m/s (P < 0.001) respectively in the Chinese and Swedish subjects. cfPWV was associated (P < 0.05) with age, body mass index (BMI), mean arterial pressure (MAP), heart rate, fasting... (More)

Carotid-femoral pulse wave velocity (cfPWV) and its risk factors may differ between various populations. Few studies have compared the risk profiles associated with cfPWV in different ethnic populations. The study population included 4321 subjects from Shanghai, China (n = 1272, age 75.0 ± 6.5 years, female 57.3%) and Malmö, Sweden (n = 3049, age 72.5 ± 5.5 years, female 60.4%). cfPWV was measured using the SphygmoCor device in both cohorts, with some difference in the determination of pulse transmission distance. The median cfPWV was 8.9 and 10.1 m/s (P < 0.001) respectively in the Chinese and Swedish subjects. cfPWV was associated (P < 0.05) with age, body mass index (BMI), mean arterial pressure (MAP), heart rate, fasting plasma glucose and serum triglycerides in both populations. The standardized effect size (m/s) associated with age (0.091 vs. 0.048, P < 0.001) and fasting plasma glucose (0.025 vs. 0.012, P = 0.046) was greater in the Swedish than Chinese subjects, whereas those with BMI (0.046 vs. 0.008, P < 0.001), MAP (0.079 vs. 0.067, P = 0.016), and heart rate (0.057 vs. 0.046, P = 0.036) were greater in Chinese. No difference was observed in those associated with serum triglycerides (P = 0.128). cfPWV was additionally associated with sex, serum total cholesterol, and on antihypertensive medication in the Swedish subjects, and with serum uric acid in the Chinese subjects (P ≤ 0.041). In conclusion, Chinese and Swedish subjects shared similar major risk factors of arterial stiffness, but with some differences in the strength of associations.

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published
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in
Journal of Human Hypertension
publisher
Nature Publishing Group
external identifiers
  • scopus:85060174371
ISSN
0950-9240
DOI
10.1038/s41371-018-0160-0
language
English
LU publication?
yes
id
b2235fd5-b5ff-4c6a-80f9-31f42ec120e0
date added to LUP
2019-01-30 11:46:55
date last changed
2019-02-20 11:45:54
@article{b2235fd5-b5ff-4c6a-80f9-31f42ec120e0,
  abstract     = {<p>Carotid-femoral pulse wave velocity (cfPWV) and its risk factors may differ between various populations. Few studies have compared the risk profiles associated with cfPWV in different ethnic populations. The study population included 4321 subjects from Shanghai, China (n = 1272, age 75.0 ± 6.5 years, female 57.3%) and Malmö, Sweden (n = 3049, age 72.5 ± 5.5 years, female 60.4%). cfPWV was measured using the SphygmoCor device in both cohorts, with some difference in the determination of pulse transmission distance. The median cfPWV was 8.9 and 10.1 m/s (P &lt; 0.001) respectively in the Chinese and Swedish subjects. cfPWV was associated (P &lt; 0.05) with age, body mass index (BMI), mean arterial pressure (MAP), heart rate, fasting plasma glucose and serum triglycerides in both populations. The standardized effect size (m/s) associated with age (0.091 vs. 0.048, P &lt; 0.001) and fasting plasma glucose (0.025 vs. 0.012, P = 0.046) was greater in the Swedish than Chinese subjects, whereas those with BMI (0.046 vs. 0.008, P &lt; 0.001), MAP (0.079 vs. 0.067, P = 0.016), and heart rate (0.057 vs. 0.046, P = 0.036) were greater in Chinese. No difference was observed in those associated with serum triglycerides (P = 0.128). cfPWV was additionally associated with sex, serum total cholesterol, and on antihypertensive medication in the Swedish subjects, and with serum uric acid in the Chinese subjects (P ≤ 0.041). In conclusion, Chinese and Swedish subjects shared similar major risk factors of arterial stiffness, but with some differences in the strength of associations.</p>},
  author       = {Guo, Qian Hui and Muhammad, Iram Faqir and Borné, Yan and Sheng, Chang Sheng and Persson, Margaretha and Wang, Ji Guang and Engström, Gunnar and Li, Yan and Nilsson, Peter M.},
  issn         = {0950-9240},
  language     = {eng},
  month        = {01},
  publisher    = {Nature Publishing Group},
  series       = {Journal of Human Hypertension},
  title        = {Difference in the risk profiles of carotid-femoral pulse wave velocity : results from two community-based studies in China and Sweden},
  url          = {http://dx.doi.org/10.1038/s41371-018-0160-0},
  year         = {2019},
}