Advanced

A Mismatch Between the Abnormalities in Diffusion- and Susceptibility-Weighted Magnetic Resonance Imaging May Represent an Acute Ischemic Penumbra with Misery Perfusion

Fujioka, Masayuki ; Okuchi, Kazuo ; Iwamura, Asami ; Taoka, Toshiaki and Siesjö, Bo LU (2013) In Journal of Stroke & Cerebrovascular Diseases 22(8). p.1428-1431
Abstract
Susceptibility-weighted imaging (SWI) has recently attracted attention for its ability to investigate acute stroke pathophysiology. SWI detects an increased ratio of deoxyhemoglobin to oxyhemoglobin in cerebral venous compartments, which can illustrate cerebral misery perfusion with a compensatory increase of oxygen extraction fraction in the hypoperfused brain. In this study we make the first case report of blunt cervical trauma leading to a stroke, demonstrating the disparity between diffusion-weighted imaging (DWI) and SWI changes, or DWI-SWI mismatch, in the acute ischemic brain. The area of mismatch between a smaller DWI cytotoxic edema and a larger SWI misery perfusion in our patient matured into a complete infarction with time. The... (More)
Susceptibility-weighted imaging (SWI) has recently attracted attention for its ability to investigate acute stroke pathophysiology. SWI detects an increased ratio of deoxyhemoglobin to oxyhemoglobin in cerebral venous compartments, which can illustrate cerebral misery perfusion with a compensatory increase of oxygen extraction fraction in the hypoperfused brain. In this study we make the first case report of blunt cervical trauma leading to a stroke, demonstrating the disparity between diffusion-weighted imaging (DWI) and SWI changes, or DWI-SWI mismatch, in the acute ischemic brain. The area of mismatch between a smaller DWI cytotoxic edema and a larger SWI misery perfusion in our patient matured into a complete infarction with time. The DWI-SWI mismatch may signify the presence of an ischemic penumbra, and provide information about viability of the brain tissue at risk of potential infarction if without early reperfusion. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Diffusion-weighted imaging, susceptibility-weighted imaging, ischemic-penumbra, misery-perfusion, brain, magnetic resonance imaging
in
Journal of Stroke & Cerebrovascular Diseases
volume
22
issue
8
pages
1428 - 1431
publisher
Elsevier
external identifiers
  • wos:000327719000110
  • scopus:84889014590
ISSN
1532-8511
DOI
10.1016/j.jstrokecerebrovasdis.2012.12.009
language
English
LU publication?
yes
id
b2258fc4-b233-4526-a5fe-d301659c1001 (old id 4273186)
date added to LUP
2016-04-01 09:49:25
date last changed
2020-01-07 01:02:35
@article{b2258fc4-b233-4526-a5fe-d301659c1001,
  abstract     = {Susceptibility-weighted imaging (SWI) has recently attracted attention for its ability to investigate acute stroke pathophysiology. SWI detects an increased ratio of deoxyhemoglobin to oxyhemoglobin in cerebral venous compartments, which can illustrate cerebral misery perfusion with a compensatory increase of oxygen extraction fraction in the hypoperfused brain. In this study we make the first case report of blunt cervical trauma leading to a stroke, demonstrating the disparity between diffusion-weighted imaging (DWI) and SWI changes, or DWI-SWI mismatch, in the acute ischemic brain. The area of mismatch between a smaller DWI cytotoxic edema and a larger SWI misery perfusion in our patient matured into a complete infarction with time. The DWI-SWI mismatch may signify the presence of an ischemic penumbra, and provide information about viability of the brain tissue at risk of potential infarction if without early reperfusion.},
  author       = {Fujioka, Masayuki and Okuchi, Kazuo and Iwamura, Asami and Taoka, Toshiaki and Siesjö, Bo},
  issn         = {1532-8511},
  language     = {eng},
  number       = {8},
  pages        = {1428--1431},
  publisher    = {Elsevier},
  series       = {Journal of Stroke & Cerebrovascular Diseases},
  title        = {A Mismatch Between the Abnormalities in Diffusion- and Susceptibility-Weighted Magnetic Resonance Imaging May Represent an Acute Ischemic Penumbra with Misery Perfusion},
  url          = {http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2012.12.009},
  doi          = {10.1016/j.jstrokecerebrovasdis.2012.12.009},
  volume       = {22},
  year         = {2013},
}