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A fully automatic algorithm for assessing T2* and its certainty value for accurate cardiac and liver iron load determination

Hedström, Erik LU ; Heiberg, Einar LU ; Greil, Gerald F and Nagel, Eike (2013) 16th Annual SCMR Scientific Sessions In Journal of Cardiovascular Magnetic Resonance 15(Suppl 1).
Abstract
Quantification of myocardial and liver iron load has become a mainstay of guiding therapy in thalassaemia patients. However, current quantification methods are user dependent for data-point exclusion before curve fitting, and do not report the T2* certainty. Recently, an automatic inline maximum likelihood estimate (MLE) method with k-space Rician noise correction was validated against the reference standard manual truncation method. We now present a vendor-independent offline tool for fully automatic post processing and T2* quantification with certainty estimates, tested in computer simulations and patients with iron overload.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Cardiovascular Magnetic Resonance
volume
15
issue
Suppl 1
publisher
BioMed Central
conference name
16th Annual SCMR Scientific Sessions
ISSN
1097-6647
DOI
10.1186/1532-429X-15-S1-P141
language
English
LU publication?
yes
id
b2562262-26a0-4e76-8a31-4c5bf34b2a13
alternative location
http://www.jcmr-online.com/content/15/S1/P141
date added to LUP
2017-02-02 11:37:55
date last changed
2017-02-09 14:33:53
@article{b2562262-26a0-4e76-8a31-4c5bf34b2a13,
  abstract     = {Quantification of myocardial and liver iron load has become a mainstay of guiding therapy in thalassaemia patients. However, current quantification methods are user dependent for data-point exclusion before curve fitting, and do not report the T2* certainty. Recently, an automatic inline maximum likelihood estimate (MLE) method with k-space Rician noise correction was validated against the reference standard manual truncation method. We now present a vendor-independent offline tool for fully automatic post processing and T2* quantification with certainty estimates, tested in computer simulations and patients with iron overload.},
  articleno    = {P141},
  author       = {Hedström, Erik and Heiberg, Einar and Greil, Gerald F and Nagel, Eike},
  issn         = {1097-6647},
  language     = {eng},
  month        = {01},
  number       = {Suppl 1},
  publisher    = {BioMed Central},
  series       = {Journal of Cardiovascular Magnetic Resonance},
  title        = {A fully automatic algorithm for assessing T2* and its certainty value for accurate cardiac and liver iron load determination},
  url          = {http://dx.doi.org/10.1186/1532-429X-15-S1-P141},
  volume       = {15},
  year         = {2013},
}