Thymoma : a clinicopathological correlation of 1470 cases
(2018) In Human Pathology 73. p.7-15- Abstract
We present 1470 surgical resections for thymoma identified in the pathology files of 14 institutions from 11 countries with the purpose of determining and correlating a simplified histological classification of thymoma and pathological staging with clinical outcome. The study population was composed of 720 men and 750 women between the ages of 12 and 86 years (average, 54.8 years). Clinically, 137 patients (17%) had a history of myasthenia gravis, 31 patients (3.8%) of other autoimmune disease, and 55 (6.8%) patients of another neoplastic process. Surgical resection was performed in all patients. Histologically, 1284 (87.13%) cases were thymomas (World Health Organization types A, B1, and B2, and mixed histologies), and 186 (12.7%) were... (More)
We present 1470 surgical resections for thymoma identified in the pathology files of 14 institutions from 11 countries with the purpose of determining and correlating a simplified histological classification of thymoma and pathological staging with clinical outcome. The study population was composed of 720 men and 750 women between the ages of 12 and 86 years (average, 54.8 years). Clinically, 137 patients (17%) had a history of myasthenia gravis, 31 patients (3.8%) of other autoimmune disease, and 55 (6.8%) patients of another neoplastic process. Surgical resection was performed in all patients. Histologically, 1284 (87.13%) cases were thymomas (World Health Organization types A, B1, and B2, and mixed histologies), and 186 (12.7%) were atypical thymomas (World Health Organization type B3). Of the entire group, 630 (42.9%) were encapsulated thymomas, and 840 (57.9%) were invasive thymomas in different stages. Follow-up information was obtained in 1339 (91%) patients, who subsequently were analyzed by univariate and multivariate statistical analysis. Follow-up ranging from 1 to 384 months was obtained (mean, 69.2 months) showing tumor recurrence in 136 patients (10.1%), whereas 227 died: 64 (28.2%) due to tumor and 163 (71.8%) due to other causes. Statistical analysis shows that separation of these tumors into thymoma and atypical thymoma is statistically significant (P =.001), whereas tumor staging into categories of encapsulated, minimally invasive, and invasion into adjacent organs offers a meaningful clinical assessment with a P =.038. Our findings suggest that our simplified histological schema and pathological staging system are excellent predictors of clinical outcome.
(Less)
- author
- Weissferdt, Annikka
; Kalhor, Neda
; Bishop, Justin A.
; Jang, Se Jin
; Ro, Jae
; Petersson, Fredrik
; Wu, Bingcheng
; Langman, Gerald
; Bancroft, Hollie
; Bi, Yalan
; Meng, Yunxiao
; Medeiros, Filomena
; Brunnstrom, Hans
LU
; Spagnolo, Dominic
; Chai, Siaw Ming
; Laycock, Andrew
; Wakely, Paul E.
; Elmberger, Goran
; Soares, Fernando A.
; Campos, Antonio H.
; Gumurdulu, Derya
; Alvarado-Cabrero, Isabel
; Coppola, Domenico
; Correa, Arlene M.
; Rice, David
; Mehran, Reza J.
; Sepesi, Boris
; Walsh, Garrett
; Kaiser, Larry
and Moran, Cesar A.
(Less) - organization
- publishing date
- 2018-03-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Classification, Mediastinum, Staging, Thymoma, Thymus
- in
- Human Pathology
- volume
- 73
- pages
- 9 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:28851660
- scopus:85042917306
- ISSN
- 0046-8177
- DOI
- 10.1016/j.humpath.2017.08.018
- language
- English
- LU publication?
- yes
- id
- b2586231-afd3-40c5-baf0-46fa2d759f4d
- date added to LUP
- 2018-04-12 12:52:31
- date last changed
- 2024-04-15 05:19:02
@article{b2586231-afd3-40c5-baf0-46fa2d759f4d,
abstract = {{<p>We present 1470 surgical resections for thymoma identified in the pathology files of 14 institutions from 11 countries with the purpose of determining and correlating a simplified histological classification of thymoma and pathological staging with clinical outcome. The study population was composed of 720 men and 750 women between the ages of 12 and 86 years (average, 54.8 years). Clinically, 137 patients (17%) had a history of myasthenia gravis, 31 patients (3.8%) of other autoimmune disease, and 55 (6.8%) patients of another neoplastic process. Surgical resection was performed in all patients. Histologically, 1284 (87.13%) cases were thymomas (World Health Organization types A, B1, and B2, and mixed histologies), and 186 (12.7%) were atypical thymomas (World Health Organization type B3). Of the entire group, 630 (42.9%) were encapsulated thymomas, and 840 (57.9%) were invasive thymomas in different stages. Follow-up information was obtained in 1339 (91%) patients, who subsequently were analyzed by univariate and multivariate statistical analysis. Follow-up ranging from 1 to 384 months was obtained (mean, 69.2 months) showing tumor recurrence in 136 patients (10.1%), whereas 227 died: 64 (28.2%) due to tumor and 163 (71.8%) due to other causes. Statistical analysis shows that separation of these tumors into thymoma and atypical thymoma is statistically significant (P =.001), whereas tumor staging into categories of encapsulated, minimally invasive, and invasion into adjacent organs offers a meaningful clinical assessment with a P =.038. Our findings suggest that our simplified histological schema and pathological staging system are excellent predictors of clinical outcome.</p>}},
author = {{Weissferdt, Annikka and Kalhor, Neda and Bishop, Justin A. and Jang, Se Jin and Ro, Jae and Petersson, Fredrik and Wu, Bingcheng and Langman, Gerald and Bancroft, Hollie and Bi, Yalan and Meng, Yunxiao and Medeiros, Filomena and Brunnstrom, Hans and Spagnolo, Dominic and Chai, Siaw Ming and Laycock, Andrew and Wakely, Paul E. and Elmberger, Goran and Soares, Fernando A. and Campos, Antonio H. and Gumurdulu, Derya and Alvarado-Cabrero, Isabel and Coppola, Domenico and Correa, Arlene M. and Rice, David and Mehran, Reza J. and Sepesi, Boris and Walsh, Garrett and Kaiser, Larry and Moran, Cesar A.}},
issn = {{0046-8177}},
keywords = {{Classification; Mediastinum; Staging; Thymoma; Thymus}},
language = {{eng}},
month = {{03}},
pages = {{7--15}},
publisher = {{Elsevier}},
series = {{Human Pathology}},
title = {{Thymoma : a clinicopathological correlation of 1470 cases}},
url = {{http://dx.doi.org/10.1016/j.humpath.2017.08.018}},
doi = {{10.1016/j.humpath.2017.08.018}},
volume = {{73}},
year = {{2018}},
}