Associations between hand osteoarthritis, obesity and lipid metabolism : a cross-sectional study of the Halland County Osteoarthritis (HALLOA) cohort
Brogren, Elisabeth LU ; Andersson, Maria LU
; Westenius, Melker
; Wittrup, Jenny
LU
and Zimmerman, Malin
LU
(2024)
In BMC Musculoskeletal Disorders
25(1).
- Abstract
Background: To determine whether obesity and markers of lipid metabolism are associated with radiological hand osteoarthritis (OA) in the Halland County Osteoarthritis (HALLOA) cohort. Methods: In this cross-sectional study, we included 231 participants aged 30–65 from the HALLOA cohort, which began in 2017 and is ongoing. Hand OA was defined as ≥ 2 joint groups (distal interphalangeal, proximal interphalangeal, and carpometacarpal I) with Kellgren-Lawrence grade ≥ 2. The severity of hand OA was classified in terms of the number of affected joint groups (moderate hand OA 2–4 joint groups, severe hand OA 5–6 joint groups). Metabolic profile, including body mass index (BMI), bioimpedance, waist circumference, blood pressure, serum leptin,... (More)
Background: To determine whether obesity and markers of lipid metabolism are associated with radiological hand osteoarthritis (OA) in the Halland County Osteoarthritis (HALLOA) cohort. Methods: In this cross-sectional study, we included 231 participants aged 30–65 from the HALLOA cohort, which began in 2017 and is ongoing. Hand OA was defined as ≥ 2 joint groups (distal interphalangeal, proximal interphalangeal, and carpometacarpal I) with Kellgren-Lawrence grade ≥ 2. The severity of hand OA was classified in terms of the number of affected joint groups (moderate hand OA 2–4 joint groups, severe hand OA 5–6 joint groups). Metabolic profile, including body mass index (BMI), bioimpedance, waist circumference, blood pressure, serum leptin, total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and triglycerides, were obtained. Multicollinearity was assessed with Pearson’s correlation and associations with logistic regression analyses adjusting for age, HDL-cholesterol, and central obesity. Results: Two-thirds of the participants were women, and 91 (39%) had hand OA. We found a relationship between LDL-cholesterol and prevalent hand OA in women with an odds ratio of 1.7 (95% CI 1.1–2.6) and an association between LDL-cholesterol and severity of hand OA in women; odds ratio for no hand OA vs. moderate hand OA was 1.6 (95% CI 1.0-2.4) and for no hand OA vs. severe hand OA 2.5 (95% CI 1.2–4.9). There were no significant relationships between hand OA and obesity or serum leptin levels. Conclusion: Circulating LDL-cholesterol levels were associated with the prevalence and severity of hand OA in women but not men. Trial registration: ClinicalTrials. Gov (NCT04928170), Date of registration: 2017-12-20.
(Less)
- author
- Brogren, Elisabeth
LU
; Andersson, Maria
LU
; Westenius, Melker
; Wittrup, Jenny
LU
and Zimmerman, Malin
LU
- organization
- publishing date
- 2024-12
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Body mass index, Cholesterol, HDL, Cholesterol, LDL, Lipid metabolism, Obestity, Abdominal, Osteoarthritis
- in
- BMC Musculoskeletal Disorders
- volume
- 25
- issue
- 1
- article number
- 944
- publisher
- BioMed Central (BMC)
- external identifiers
-
- pmid:39578778
- scopus:85209765321
- ISSN
- 1471-2474
- DOI
- 10.1186/s12891-024-08073-x
- language
- English
- LU publication?
- yes
- id
- b2ce850a-50da-4ee7-9b1f-70b3514b686f
- date added to LUP
- 2025-01-09 09:56:05
- date last changed
- 2025-07-11 01:21:09
@article{b2ce850a-50da-4ee7-9b1f-70b3514b686f,
abstract = {{<p>Background: To determine whether obesity and markers of lipid metabolism are associated with radiological hand osteoarthritis (OA) in the Halland County Osteoarthritis (HALLOA) cohort. Methods: In this cross-sectional study, we included 231 participants aged 30–65 from the HALLOA cohort, which began in 2017 and is ongoing. Hand OA was defined as ≥ 2 joint groups (distal interphalangeal, proximal interphalangeal, and carpometacarpal I) with Kellgren-Lawrence grade ≥ 2. The severity of hand OA was classified in terms of the number of affected joint groups (moderate hand OA 2–4 joint groups, severe hand OA 5–6 joint groups). Metabolic profile, including body mass index (BMI), bioimpedance, waist circumference, blood pressure, serum leptin, total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and triglycerides, were obtained. Multicollinearity was assessed with Pearson’s correlation and associations with logistic regression analyses adjusting for age, HDL-cholesterol, and central obesity. Results: Two-thirds of the participants were women, and 91 (39%) had hand OA. We found a relationship between LDL-cholesterol and prevalent hand OA in women with an odds ratio of 1.7 (95% CI 1.1–2.6) and an association between LDL-cholesterol and severity of hand OA in women; odds ratio for no hand OA vs. moderate hand OA was 1.6 (95% CI 1.0-2.4) and for no hand OA vs. severe hand OA 2.5 (95% CI 1.2–4.9). There were no significant relationships between hand OA and obesity or serum leptin levels. Conclusion: Circulating LDL-cholesterol levels were associated with the prevalence and severity of hand OA in women but not men. Trial registration: ClinicalTrials. Gov (NCT04928170), Date of registration: 2017-12-20.</p>}},
author = {{Brogren, Elisabeth and Andersson, Maria and Westenius, Melker and Wittrup, Jenny and Zimmerman, Malin}},
issn = {{1471-2474}},
keywords = {{Body mass index; Cholesterol, HDL; Cholesterol, LDL; Lipid metabolism; Obestity, Abdominal; Osteoarthritis}},
language = {{eng}},
number = {{1}},
publisher = {{BioMed Central (BMC)}},
series = {{BMC Musculoskeletal Disorders}},
title = {{Associations between hand osteoarthritis, obesity and lipid metabolism : a cross-sectional study of the Halland County Osteoarthritis (HALLOA) cohort}},
url = {{http://dx.doi.org/10.1186/s12891-024-08073-x}},
doi = {{10.1186/s12891-024-08073-x}},
volume = {{25}},
year = {{2024}},
}