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Novel assay to improve therapeutic drug monitoring of thiopurines in inflammatory bowel disease.

Vikingsson, Svante ; Andersson, David LU ; Almer, Sven ; Peterson, Curt and Hindorf, Ulf LU (2014) In Journal of Crohn's & Colitis 8(12). p.1702-1709
Abstract
The thiopurines are widely used in the treatment of inflammatory bowel disease, but are limited by poor dose-effect relationship. The objective was to assess the ability of a novel assay, determining the mono-, di-, and triphosphates, of thioguanine as well as methylthioinosine as individual metabolites in erythrocytes, to predict clinical outcome compared to a routine assay, determining metabolites as sums.
Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Crohn's & Colitis
volume
8
issue
12
pages
1702 - 1709
publisher
Oxford University Press
external identifiers
  • pmid:25239576
  • wos:000347019600016
  • scopus:84918500592
ISSN
1873-9946
DOI
10.1016/j.crohns.2014.08.009
language
English
LU publication?
yes
id
b2d3dd05-8854-44ac-841d-e9b01debac36 (old id 4691187)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25239576?dopt=Abstract
date added to LUP
2016-04-01 10:46:45
date last changed
2025-10-14 10:58:06
@article{b2d3dd05-8854-44ac-841d-e9b01debac36,
  abstract     = {{The thiopurines are widely used in the treatment of inflammatory bowel disease, but are limited by poor dose-effect relationship. The objective was to assess the ability of a novel assay, determining the mono-, di-, and triphosphates, of thioguanine as well as methylthioinosine as individual metabolites in erythrocytes, to predict clinical outcome compared to a routine assay, determining metabolites as sums.}},
  author       = {{Vikingsson, Svante and Andersson, David and Almer, Sven and Peterson, Curt and Hindorf, Ulf}},
  issn         = {{1873-9946}},
  language     = {{eng}},
  number       = {{12}},
  pages        = {{1702--1709}},
  publisher    = {{Oxford University Press}},
  series       = {{Journal of Crohn's & Colitis}},
  title        = {{Novel assay to improve therapeutic drug monitoring of thiopurines in inflammatory bowel disease.}},
  url          = {{http://dx.doi.org/10.1016/j.crohns.2014.08.009}},
  doi          = {{10.1016/j.crohns.2014.08.009}},
  volume       = {{8}},
  year         = {{2014}},
}