The impact of inflammatory lipid mediators on colon cancer-initiating cells.
(2015) In Molecular Carcinogenesis 54(11). p.1315-1327- Abstract
- The role of inflammatory lipid-mediators in tumor progression is well recognized in colorectal cancer; however, if this includes promotion of cancer-initiating cells remains unclear. We show that the inflammatory lipid-mediators leukotriene D4 and prostaglandin E2 increased the Aldehyde dehydrogenase (ALDH(+) ) population, the colony formation capacity, and tumor growth in a xenograft model of colon cancer. The ALDH(+) cells showed significant resistance to irradiation and 5-fluorouracil treatment that could be further augmented by these lipid-mediators, occurring in parallel with increased target gene expression. Our data emphasize a role for tumor microenvironment derived inflammatory lipid-mediators to favor cancer stem cells-like... (More)
- The role of inflammatory lipid-mediators in tumor progression is well recognized in colorectal cancer; however, if this includes promotion of cancer-initiating cells remains unclear. We show that the inflammatory lipid-mediators leukotriene D4 and prostaglandin E2 increased the Aldehyde dehydrogenase (ALDH(+) ) population, the colony formation capacity, and tumor growth in a xenograft model of colon cancer. The ALDH(+) cells showed significant resistance to irradiation and 5-fluorouracil treatment that could be further augmented by these lipid-mediators, occurring in parallel with increased target gene expression. Our data emphasize a role for tumor microenvironment derived inflammatory lipid-mediators to favor cancer stem cells-like characteristics and thus promote tumor progression. © 2014 Wiley Periodicals, Inc. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4614004
- author
- Bellamkonda, Kishan LU ; Sime, Wondossen LU and Sjölander, Anita LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Molecular Carcinogenesis
- volume
- 54
- issue
- 11
- pages
- 1315 - 1327
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:25154976
- wos:000363220700008
- scopus:84945198930
- pmid:25154976
- ISSN
- 1098-2744
- DOI
- 10.1002/mc.22207
- language
- English
- LU publication?
- yes
- id
- b31fb6e0-1f0b-41fb-bd43-02fdb9012cd3 (old id 4614004)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25154976?dopt=Abstract
- date added to LUP
- 2016-04-01 09:47:51
- date last changed
- 2022-03-11 23:06:59
@article{b31fb6e0-1f0b-41fb-bd43-02fdb9012cd3,
abstract = {{The role of inflammatory lipid-mediators in tumor progression is well recognized in colorectal cancer; however, if this includes promotion of cancer-initiating cells remains unclear. We show that the inflammatory lipid-mediators leukotriene D4 and prostaglandin E2 increased the Aldehyde dehydrogenase (ALDH(+) ) population, the colony formation capacity, and tumor growth in a xenograft model of colon cancer. The ALDH(+) cells showed significant resistance to irradiation and 5-fluorouracil treatment that could be further augmented by these lipid-mediators, occurring in parallel with increased target gene expression. Our data emphasize a role for tumor microenvironment derived inflammatory lipid-mediators to favor cancer stem cells-like characteristics and thus promote tumor progression. © 2014 Wiley Periodicals, Inc.}},
author = {{Bellamkonda, Kishan and Sime, Wondossen and Sjölander, Anita}},
issn = {{1098-2744}},
language = {{eng}},
number = {{11}},
pages = {{1315--1327}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Molecular Carcinogenesis}},
title = {{The impact of inflammatory lipid mediators on colon cancer-initiating cells.}},
url = {{http://dx.doi.org/10.1002/mc.22207}},
doi = {{10.1002/mc.22207}},
volume = {{54}},
year = {{2015}},
}