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Enzymatically Polymerized Organic Conductors on Model Lipid Membranes

Priyadarshini, Diana ; Musumeci, Chiara ; Bliman, David LU ; Abrahamsson, Tobias ; Lindholm, Caroline ; Vagin, Mikhail ; Strakosas, Xenofon LU ; Olsson, Roger LU orcid ; Berggren, Magnus and Gerasimov, Jennifer Y. , et al. (2023) In Langmuir 39(23). p.8196-8204
Abstract

Seamless integration between biological systems and electrical components is essential for enabling a twinned biochemical-electrical recording and therapy approach to understand and combat neurological disorders. Employing bioelectronic systems made up of conjugated polymers, which have an innate ability to transport both electronic and ionic charges, provides the possibility of such integration. In particular, translating enzymatically polymerized conductive wires, recently demonstrated in plants and simple organism systems, into mammalian models, is of particular interest for the development of next-generation devices that can monitor and modulate neural signals. As a first step toward achieving this goal, enzyme-mediated... (More)

Seamless integration between biological systems and electrical components is essential for enabling a twinned biochemical-electrical recording and therapy approach to understand and combat neurological disorders. Employing bioelectronic systems made up of conjugated polymers, which have an innate ability to transport both electronic and ionic charges, provides the possibility of such integration. In particular, translating enzymatically polymerized conductive wires, recently demonstrated in plants and simple organism systems, into mammalian models, is of particular interest for the development of next-generation devices that can monitor and modulate neural signals. As a first step toward achieving this goal, enzyme-mediated polymerization of two thiophene-based monomers is demonstrated on a synthetic lipid bilayer supported on a Au surface. Microgravimetric studies of conducting films polymerized in situ provide insights into their interactions with a lipid bilayer model that mimics the cell membrane. Moreover, the resulting electrical and viscoelastic properties of these self-organizing conducting polymers suggest their potential as materials to form the basis for novel approaches to in vivo neural therapeutics.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Langmuir
volume
39
issue
23
pages
9 pages
publisher
The American Chemical Society (ACS)
external identifiers
  • pmid:37267478
  • scopus:85163252055
ISSN
0743-7463
DOI
10.1021/acs.langmuir.3c00654
language
English
LU publication?
yes
id
b33235db-143f-44f1-b694-eb8fec7761ee
date added to LUP
2023-09-15 11:08:35
date last changed
2024-04-20 03:24:45
@article{b33235db-143f-44f1-b694-eb8fec7761ee,
  abstract     = {{<p>Seamless integration between biological systems and electrical components is essential for enabling a twinned biochemical-electrical recording and therapy approach to understand and combat neurological disorders. Employing bioelectronic systems made up of conjugated polymers, which have an innate ability to transport both electronic and ionic charges, provides the possibility of such integration. In particular, translating enzymatically polymerized conductive wires, recently demonstrated in plants and simple organism systems, into mammalian models, is of particular interest for the development of next-generation devices that can monitor and modulate neural signals. As a first step toward achieving this goal, enzyme-mediated polymerization of two thiophene-based monomers is demonstrated on a synthetic lipid bilayer supported on a Au surface. Microgravimetric studies of conducting films polymerized in situ provide insights into their interactions with a lipid bilayer model that mimics the cell membrane. Moreover, the resulting electrical and viscoelastic properties of these self-organizing conducting polymers suggest their potential as materials to form the basis for novel approaches to in vivo neural therapeutics.</p>}},
  author       = {{Priyadarshini, Diana and Musumeci, Chiara and Bliman, David and Abrahamsson, Tobias and Lindholm, Caroline and Vagin, Mikhail and Strakosas, Xenofon and Olsson, Roger and Berggren, Magnus and Gerasimov, Jennifer Y. and Simon, Daniel T.}},
  issn         = {{0743-7463}},
  language     = {{eng}},
  number       = {{23}},
  pages        = {{8196--8204}},
  publisher    = {{The American Chemical Society (ACS)}},
  series       = {{Langmuir}},
  title        = {{Enzymatically Polymerized Organic Conductors on Model Lipid Membranes}},
  url          = {{http://dx.doi.org/10.1021/acs.langmuir.3c00654}},
  doi          = {{10.1021/acs.langmuir.3c00654}},
  volume       = {{39}},
  year         = {{2023}},
}