Individual participant data (IPD)-level meta-analysis of randomised controlled trials with vitamin D-fortified foods to estimate Dietary Reference Values for vitamin D
(2021) In European Journal of Nutrition 60(2). p.939-959- Abstract
Context and purpose: Individual participant data-level meta-regression (IPD) analysis is superior to meta-regression based on aggregate data in determining Dietary Reference Values (DRV) for vitamin D. Using data from randomized controlled trials (RCTs) with vitamin D3-fortified foods, we undertook an IPD analysis of the response of winter serum 25-hydroxyvitamin (25(OH)D) to total vitamin D intake among children and adults and derived DRV for vitamin D. Methods: IPD analysis using data from 1429 participants (ages 2–89 years) in 11 RCTs with vitamin D-fortified foods identified via a systematic review and predefined eligibility criteria. Outcome measures were vitamin D DRV estimates across a range of serum 25(OH)D thresholds... (More)
Context and purpose: Individual participant data-level meta-regression (IPD) analysis is superior to meta-regression based on aggregate data in determining Dietary Reference Values (DRV) for vitamin D. Using data from randomized controlled trials (RCTs) with vitamin D3-fortified foods, we undertook an IPD analysis of the response of winter serum 25-hydroxyvitamin (25(OH)D) to total vitamin D intake among children and adults and derived DRV for vitamin D. Methods: IPD analysis using data from 1429 participants (ages 2–89 years) in 11 RCTs with vitamin D-fortified foods identified via a systematic review and predefined eligibility criteria. Outcome measures were vitamin D DRV estimates across a range of serum 25(OH)D thresholds using unadjusted and adjusted models. Results: Our IPD-derived estimates of vitamin D intakes required to maintain 97.5% of winter 25(OH)D concentrations ≥ 25 and ≥ 30 nmol/L are 6 and 12 µg/day, respectively (unadjusted model). The intake estimates to maintain 90%, 95% and 97.5% of concentrations ≥ 50 nmol/L are 33.4, 57.5 and 92.3 µg/day, respectively (unadjusted) and 17.0, 28.1 and 43.6 µg/day, respectively (adjusted for mean values for baseline serum 25(OH)D, age and BMI). Conclusions: IPD-derived vitamin D intakes required to maintain 90%, 95% and 97.5% of winter 25(OH)D concentrations ≥ 50 nmol/L are much higher than those derived from standard meta-regression based on aggregate data, due to the inability of the latter to capture between person-variability. Our IPD provides further evidence that using food-based approaches to achieve an intake of 12 µg/day could prevent vitamin D deficiency (i.e., serum 25(OH)D < 30 nmol/L) in the general population.
(Less)
- author
- organization
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Dietary reference values, Individual participant data-level meta-regression analyses, Recommended dietary allowance, Vitamin D recommendations, Vitamin D-fortified foods
- in
- European Journal of Nutrition
- volume
- 60
- issue
- 2
- pages
- 939 - 959
- publisher
- Springer
- external identifiers
-
- scopus:85086574425
- pmid:32556447
- ISSN
- 1436-6207
- DOI
- 10.1007/s00394-020-02298-x
- language
- English
- LU publication?
- yes
- id
- b35081b1-abc9-47d1-a55d-7289689a3cb4
- date added to LUP
- 2020-06-29 12:03:00
- date last changed
- 2024-06-26 17:51:34
@article{b35081b1-abc9-47d1-a55d-7289689a3cb4,
abstract = {{<p>Context and purpose: Individual participant data-level meta-regression (IPD) analysis is superior to meta-regression based on aggregate data in determining Dietary Reference Values (DRV) for vitamin D. Using data from randomized controlled trials (RCTs) with vitamin D<sub>3</sub>-fortified foods, we undertook an IPD analysis of the response of winter serum 25-hydroxyvitamin (25(OH)D) to total vitamin D intake among children and adults and derived DRV for vitamin D. Methods: IPD analysis using data from 1429 participants (ages 2–89 years) in 11 RCTs with vitamin D-fortified foods identified via a systematic review and predefined eligibility criteria. Outcome measures were vitamin D DRV estimates across a range of serum 25(OH)D thresholds using unadjusted and adjusted models. Results: Our IPD-derived estimates of vitamin D intakes required to maintain 97.5% of winter 25(OH)D concentrations ≥ 25 and ≥ 30 nmol/L are 6 and 12 µg/day, respectively (unadjusted model). The intake estimates to maintain 90%, 95% and 97.5% of concentrations ≥ 50 nmol/L are 33.4, 57.5 and 92.3 µg/day, respectively (unadjusted) and 17.0, 28.1 and 43.6 µg/day, respectively (adjusted for mean values for baseline serum 25(OH)D, age and BMI). Conclusions: IPD-derived vitamin D intakes required to maintain 90%, 95% and 97.5% of winter 25(OH)D concentrations ≥ 50 nmol/L are much higher than those derived from standard meta-regression based on aggregate data, due to the inability of the latter to capture between person-variability. Our IPD provides further evidence that using food-based approaches to achieve an intake of 12 µg/day could prevent vitamin D deficiency (i.e., serum 25(OH)D < 30 nmol/L) in the general population.</p>}},
author = {{Cashman, Kevin D. and Kiely, Mairead E. and Andersen, Rikke and Grønborg, Ida M. and Madsen, Katja H. and Nissen, Janna and Tetens, Inge and Tripkovic, Laura and Lanham-New, Susan A. and Toxqui, Laura and Vaquero, M. Pilar and Trautvetter, Ulrike and Jahreis, Gerhard and Mistry, Vikram V. and Specker, Bonny L. and Hower, Jürgen and Knoll, Anette and Wagner, Dennis and Vieth, Reinhold and Öhlund, Inger and Karlsland Åkeson, Pia and Brett, Neil R. and Weiler, Hope A. and Ritz, Christian}},
issn = {{1436-6207}},
keywords = {{Dietary reference values; Individual participant data-level meta-regression analyses; Recommended dietary allowance; Vitamin D recommendations; Vitamin D-fortified foods}},
language = {{eng}},
number = {{2}},
pages = {{939--959}},
publisher = {{Springer}},
series = {{European Journal of Nutrition}},
title = {{Individual participant data (IPD)-level meta-analysis of randomised controlled trials with vitamin D-fortified foods to estimate Dietary Reference Values for vitamin D}},
url = {{http://dx.doi.org/10.1007/s00394-020-02298-x}},
doi = {{10.1007/s00394-020-02298-x}},
volume = {{60}},
year = {{2021}},
}