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Aquaporin-5 in breast cancer

Bystrup, Malte ; Login, Frédéric H. ; Edamana, Sarannya ; Borgquist, Signe LU ; Tramm, Trine ; Kwon, Tae Hwan and Nejsum, Lene N. (2022) In APMIS 130(5). p.253-260
Abstract

The water channel aquaporin-5 (AQP5) is essential in transepithelial water transport in secretory glands. AQP5 is ectopically overexpressed in breast cancer, where expression is associated with lymph node metastasis and poor prognosis. Besides the role in water transport, AQP5 has been found to play a role in cancer metastasis, migration, and proliferation. AQP5 has also been shown to be involved in the dysregulation of epithelial cell–cell adhesion; frequently observed in cancers. Insight into the underlying molecular mechanisms of how AQP5 contributes to cancer development and progression is essential for potentially implementing AQP5 as a prognostic biomarker and to develop targeted intervention strategies for the treatment of breast... (More)

The water channel aquaporin-5 (AQP5) is essential in transepithelial water transport in secretory glands. AQP5 is ectopically overexpressed in breast cancer, where expression is associated with lymph node metastasis and poor prognosis. Besides the role in water transport, AQP5 has been found to play a role in cancer metastasis, migration, and proliferation. AQP5 has also been shown to be involved in the dysregulation of epithelial cell–cell adhesion; frequently observed in cancers. Insight into the underlying molecular mechanisms of how AQP5 contributes to cancer development and progression is essential for potentially implementing AQP5 as a prognostic biomarker and to develop targeted intervention strategies for the treatment of breast cancer patients.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
aquaporin-5, biomarker, breast cancer, carcinoma, migration, proliferation
in
APMIS
volume
130
issue
5
pages
8 pages
publisher
John Wiley & Sons Inc.
external identifiers
  • scopus:85125393174
  • pmid:35114014
ISSN
0903-4641
DOI
10.1111/apm.13212
language
English
LU publication?
yes
id
b3534c49-784e-40a4-acab-879367ab905b
date added to LUP
2022-04-21 15:28:53
date last changed
2024-06-19 01:39:19
@article{b3534c49-784e-40a4-acab-879367ab905b,
  abstract     = {{<p>The water channel aquaporin-5 (AQP5) is essential in transepithelial water transport in secretory glands. AQP5 is ectopically overexpressed in breast cancer, where expression is associated with lymph node metastasis and poor prognosis. Besides the role in water transport, AQP5 has been found to play a role in cancer metastasis, migration, and proliferation. AQP5 has also been shown to be involved in the dysregulation of epithelial cell–cell adhesion; frequently observed in cancers. Insight into the underlying molecular mechanisms of how AQP5 contributes to cancer development and progression is essential for potentially implementing AQP5 as a prognostic biomarker and to develop targeted intervention strategies for the treatment of breast cancer patients.</p>}},
  author       = {{Bystrup, Malte and Login, Frédéric H. and Edamana, Sarannya and Borgquist, Signe and Tramm, Trine and Kwon, Tae Hwan and Nejsum, Lene N.}},
  issn         = {{0903-4641}},
  keywords     = {{aquaporin-5; biomarker; breast cancer; carcinoma; migration; proliferation}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{253--260}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{APMIS}},
  title        = {{Aquaporin-5 in breast cancer}},
  url          = {{http://dx.doi.org/10.1111/apm.13212}},
  doi          = {{10.1111/apm.13212}},
  volume       = {{130}},
  year         = {{2022}},
}