Aquaporin-5 in breast cancer
(2022) In APMIS 130(5). p.253-260- Abstract
The water channel aquaporin-5 (AQP5) is essential in transepithelial water transport in secretory glands. AQP5 is ectopically overexpressed in breast cancer, where expression is associated with lymph node metastasis and poor prognosis. Besides the role in water transport, AQP5 has been found to play a role in cancer metastasis, migration, and proliferation. AQP5 has also been shown to be involved in the dysregulation of epithelial cell–cell adhesion; frequently observed in cancers. Insight into the underlying molecular mechanisms of how AQP5 contributes to cancer development and progression is essential for potentially implementing AQP5 as a prognostic biomarker and to develop targeted intervention strategies for the treatment of breast... (More)
The water channel aquaporin-5 (AQP5) is essential in transepithelial water transport in secretory glands. AQP5 is ectopically overexpressed in breast cancer, where expression is associated with lymph node metastasis and poor prognosis. Besides the role in water transport, AQP5 has been found to play a role in cancer metastasis, migration, and proliferation. AQP5 has also been shown to be involved in the dysregulation of epithelial cell–cell adhesion; frequently observed in cancers. Insight into the underlying molecular mechanisms of how AQP5 contributes to cancer development and progression is essential for potentially implementing AQP5 as a prognostic biomarker and to develop targeted intervention strategies for the treatment of breast cancer patients.
(Less)
- author
- Bystrup, Malte ; Login, Frédéric H. ; Edamana, Sarannya ; Borgquist, Signe LU ; Tramm, Trine ; Kwon, Tae Hwan and Nejsum, Lene N.
- organization
- publishing date
- 2022
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- aquaporin-5, biomarker, breast cancer, carcinoma, migration, proliferation
- in
- APMIS
- volume
- 130
- issue
- 5
- pages
- 8 pages
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- scopus:85125393174
- pmid:35114014
- ISSN
- 0903-4641
- DOI
- 10.1111/apm.13212
- language
- English
- LU publication?
- yes
- id
- b3534c49-784e-40a4-acab-879367ab905b
- date added to LUP
- 2022-04-21 15:28:53
- date last changed
- 2024-06-19 01:39:19
@article{b3534c49-784e-40a4-acab-879367ab905b, abstract = {{<p>The water channel aquaporin-5 (AQP5) is essential in transepithelial water transport in secretory glands. AQP5 is ectopically overexpressed in breast cancer, where expression is associated with lymph node metastasis and poor prognosis. Besides the role in water transport, AQP5 has been found to play a role in cancer metastasis, migration, and proliferation. AQP5 has also been shown to be involved in the dysregulation of epithelial cell–cell adhesion; frequently observed in cancers. Insight into the underlying molecular mechanisms of how AQP5 contributes to cancer development and progression is essential for potentially implementing AQP5 as a prognostic biomarker and to develop targeted intervention strategies for the treatment of breast cancer patients.</p>}}, author = {{Bystrup, Malte and Login, Frédéric H. and Edamana, Sarannya and Borgquist, Signe and Tramm, Trine and Kwon, Tae Hwan and Nejsum, Lene N.}}, issn = {{0903-4641}}, keywords = {{aquaporin-5; biomarker; breast cancer; carcinoma; migration; proliferation}}, language = {{eng}}, number = {{5}}, pages = {{253--260}}, publisher = {{John Wiley & Sons Inc.}}, series = {{APMIS}}, title = {{Aquaporin-5 in breast cancer}}, url = {{http://dx.doi.org/10.1111/apm.13212}}, doi = {{10.1111/apm.13212}}, volume = {{130}}, year = {{2022}}, }