Plants salvage deoxyribonucleosides in mitochondria.
(2014) In Nucleosides, Nucleotides & Nucleic Acids 33(4-6). p.291-295- Abstract
- Deoxyribonucleoside kinases phosphorylate deoxyribonucleosides into the corresponding 5'-monophosphate deoxyribonucleosides to supply the cell with nucleic acid precursors. In mitochondrial fractions of the model plant Arabidopsis thaliana, we detected deoxyadenosine and thymidine kinase activities, while the cytosol fraction contained six-fold lower activity and chloroplasts contained no measurable activities. In addition, a mitochondrial fraction isolated from the potato Solanum tuberosum contained thymidine kinase and deoxyadenosine kinase activities. We conclude that an active salvage of deoxyribonucleosides in plants takes place in their mitochondria. In general, the observed localization of the plant dNK activities in the... (More)
- Deoxyribonucleoside kinases phosphorylate deoxyribonucleosides into the corresponding 5'-monophosphate deoxyribonucleosides to supply the cell with nucleic acid precursors. In mitochondrial fractions of the model plant Arabidopsis thaliana, we detected deoxyadenosine and thymidine kinase activities, while the cytosol fraction contained six-fold lower activity and chloroplasts contained no measurable activities. In addition, a mitochondrial fraction isolated from the potato Solanum tuberosum contained thymidine kinase and deoxyadenosine kinase activities. We conclude that an active salvage of deoxyribonucleosides in plants takes place in their mitochondria. In general, the observed localization of the plant dNK activities in the mitochondrion suggests that plants have a different organization of the deoxyribonucleoside salvage compared to mammals. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4528223
- author
- Clausen, Anders Ranegaard LU ; Mutahir, Zeeshan LU ; Munch-Petersen, Birgitte LU and Piskur, Jure LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nucleosides, Nucleotides & Nucleic Acids
- volume
- 33
- issue
- 4-6
- pages
- 291 - 295
- publisher
- Taylor & Francis
- external identifiers
-
- pmid:24940682
- wos:000337939200018
- scopus:84903166296
- pmid:24940682
- ISSN
- 1525-7770
- DOI
- 10.1080/15257770.2013.853782
- language
- English
- LU publication?
- yes
- id
- b3c8f8a5-2e7e-43d8-a443-0fb986feaf0f (old id 4528223)
- date added to LUP
- 2016-04-01 10:36:01
- date last changed
- 2022-02-02 19:20:22
@article{b3c8f8a5-2e7e-43d8-a443-0fb986feaf0f,
abstract = {{Deoxyribonucleoside kinases phosphorylate deoxyribonucleosides into the corresponding 5'-monophosphate deoxyribonucleosides to supply the cell with nucleic acid precursors. In mitochondrial fractions of the model plant Arabidopsis thaliana, we detected deoxyadenosine and thymidine kinase activities, while the cytosol fraction contained six-fold lower activity and chloroplasts contained no measurable activities. In addition, a mitochondrial fraction isolated from the potato Solanum tuberosum contained thymidine kinase and deoxyadenosine kinase activities. We conclude that an active salvage of deoxyribonucleosides in plants takes place in their mitochondria. In general, the observed localization of the plant dNK activities in the mitochondrion suggests that plants have a different organization of the deoxyribonucleoside salvage compared to mammals.}},
author = {{Clausen, Anders Ranegaard and Mutahir, Zeeshan and Munch-Petersen, Birgitte and Piskur, Jure}},
issn = {{1525-7770}},
language = {{eng}},
number = {{4-6}},
pages = {{291--295}},
publisher = {{Taylor & Francis}},
series = {{Nucleosides, Nucleotides & Nucleic Acids}},
title = {{Plants salvage deoxyribonucleosides in mitochondria.}},
url = {{http://dx.doi.org/10.1080/15257770.2013.853782}},
doi = {{10.1080/15257770.2013.853782}},
volume = {{33}},
year = {{2014}},
}