Enteroviruses and Type 1 Diabetes : Multiple Mechanisms and Factors?
(2022) In Annual Review of Medicine 73(1).- Abstract
Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by insulin deficiency and resultant hyperglycemia. Complex interactions of genetic and environmental factors trigger the onset of autoimmune mechanisms responsible for development of autoimmunity to β cell antigens and subsequent development of T1D. A potential role of virus infections has long been hypothesized, and growing evidence continues to implicate enteroviruses as the most probable triggering viruses. Recent studies have strengthened the association between enteroviruses and development of autoimmunity in T1D patients, potentially through persistent infections. Enterovirus infections may contribute to different stages of disease development. We review data from... (More)
Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by insulin deficiency and resultant hyperglycemia. Complex interactions of genetic and environmental factors trigger the onset of autoimmune mechanisms responsible for development of autoimmunity to β cell antigens and subsequent development of T1D. A potential role of virus infections has long been hypothesized, and growing evidence continues to implicate enteroviruses as the most probable triggering viruses. Recent studies have strengthened the association between enteroviruses and development of autoimmunity in T1D patients, potentially through persistent infections. Enterovirus infections may contribute to different stages of disease development. We review data from both human cohort studies and experimental research exploring the potential roles and molecular mechanisms by which enterovirus infections can impact disease outcome. Expected final online publication date for the Annual Review of Medicine, Volume 73 is January 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
(Less)
- author
- Lloyd, Richard E ; Tamhankar, Manasi and Lernmark, Åke LU
- organization
- publishing date
- 2022
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Annual Review of Medicine
- volume
- 73
- issue
- 1
- publisher
- Annual Reviews
- external identifiers
-
- scopus:85120822510
- pmid:34794324
- ISSN
- 0066-4219
- DOI
- 10.1146/annurev-med-042320-015952
- language
- English
- LU publication?
- yes
- id
- b401a51b-1a27-495e-8fb7-b6fcf93119ed
- date added to LUP
- 2021-11-24 13:10:28
- date last changed
- 2024-09-19 18:59:29
@article{b401a51b-1a27-495e-8fb7-b6fcf93119ed, abstract = {{<p>Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by insulin deficiency and resultant hyperglycemia. Complex interactions of genetic and environmental factors trigger the onset of autoimmune mechanisms responsible for development of autoimmunity to β cell antigens and subsequent development of T1D. A potential role of virus infections has long been hypothesized, and growing evidence continues to implicate enteroviruses as the most probable triggering viruses. Recent studies have strengthened the association between enteroviruses and development of autoimmunity in T1D patients, potentially through persistent infections. Enterovirus infections may contribute to different stages of disease development. We review data from both human cohort studies and experimental research exploring the potential roles and molecular mechanisms by which enterovirus infections can impact disease outcome. Expected final online publication date for the Annual Review of Medicine, Volume 73 is January 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.</p>}}, author = {{Lloyd, Richard E and Tamhankar, Manasi and Lernmark, Åke}}, issn = {{0066-4219}}, language = {{eng}}, number = {{1}}, publisher = {{Annual Reviews}}, series = {{Annual Review of Medicine}}, title = {{Enteroviruses and Type 1 Diabetes : Multiple Mechanisms and Factors?}}, url = {{http://dx.doi.org/10.1146/annurev-med-042320-015952}}, doi = {{10.1146/annurev-med-042320-015952}}, volume = {{73}}, year = {{2022}}, }