Family history of diabetes and its relationship with insulin secretion and insulin sensitivity in Iraqi immigrants and native Swedes : a population-based cohort study
Bennet, Louise LU
; Franks, Paul W.
LU
; Zöller, Bengt
LU
and Groop, Leif
LU
(2018)
In Acta Diabetologica
55(3).
p.233-242
- Abstract
Aims: Middle Eastern immigrants to western countries are at high risk of developing type 2 diabetes. However, the heritability and impact of first-degree family history (FH) of type 2 diabetes on insulin secretion and action have not been adequately described. Methods: Citizens of Malmö, Sweden, aged 30–75 years born in Iraq or Sweden were invited to participate in this population-based study. Insulin secretion (corrected insulin response and oral disposition index) and action (insulin sensitivity index) were assessed by oral glucose tolerance tests. Results: In total, 45.7% of Iraqis (616/1348) and 27.4% of native Swedes (201/733) had FH in parent(s), sibling(s) or single parent and sibling, i.e., FH+. Approximately 8% of Iraqis and... (More)
Aims: Middle Eastern immigrants to western countries are at high risk of developing type 2 diabetes. However, the heritability and impact of first-degree family history (FH) of type 2 diabetes on insulin secretion and action have not been adequately described. Methods: Citizens of Malmö, Sweden, aged 30–75 years born in Iraq or Sweden were invited to participate in this population-based study. Insulin secretion (corrected insulin response and oral disposition index) and action (insulin sensitivity index) were assessed by oral glucose tolerance tests. Results: In total, 45.7% of Iraqis (616/1348) and 27.4% of native Swedes (201/733) had FH in parent(s), sibling(s) or single parent and sibling, i.e., FH+. Approximately 8% of Iraqis and 0.7% of Swedes had ≥ 3 sibling(s) and parent(s) with diabetes, i.e., FH++. Irrespective of family size, prediabetes and diabetes increased with family burden (FH− 29.4%; FH+ 38.8%; FH++ 61.7%) without significant differences across ethnicities. With increasing level of family burden, insulin secretion rather than insulin action decreased. Individuals with a combination of ≥ 3 siblings and parents with diabetes presented with the lowest levels of insulin secretion. Conclusions: The Iraqi immigrant population often present with a strong familial burden of type 2 diabetes with the worst glycemic control and highest diabetes risk in individuals with ≥ 3 siblings and parents with diabetes. Our data show that in a population still free from diabetes familial burden influences insulin secretion to a higher degree than insulin action and may be a logical target for intervention.
(Less)
- author
- Bennet, Louise
LU
; Franks, Paul W.
LU
; Zöller, Bengt
LU
and Groop, Leif
LU
- organization
- publishing date
- 2018
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Family history of diabetes, Insulin action, Insulin secretion, Middle East, Type 2 diabetes
- in
- Acta Diabetologica
- volume
- 55
- issue
- 3
- pages
- 233 - 242
- publisher
- Springer
- external identifiers
-
- scopus:85038814643
- pmid:29274011
- ISSN
- 0940-5429
- DOI
- 10.1007/s00592-017-1088-5
- project
- The MEDIM project
- language
- English
- LU publication?
- yes
- id
- b47cd931-fea5-4f77-878a-3fcd241acaa3
- date added to LUP
- 2018-01-02 15:26:31
- date last changed
- 2024-11-11 20:53:17
@article{b47cd931-fea5-4f77-878a-3fcd241acaa3,
abstract = {{<p>Aims: Middle Eastern immigrants to western countries are at high risk of developing type 2 diabetes. However, the heritability and impact of first-degree family history (FH) of type 2 diabetes on insulin secretion and action have not been adequately described. Methods: Citizens of Malmö, Sweden, aged 30–75 years born in Iraq or Sweden were invited to participate in this population-based study. Insulin secretion (corrected insulin response and oral disposition index) and action (insulin sensitivity index) were assessed by oral glucose tolerance tests. Results: In total, 45.7% of Iraqis (616/1348) and 27.4% of native Swedes (201/733) had FH in parent(s), sibling(s) or single parent and sibling, i.e., FH+. Approximately 8% of Iraqis and 0.7% of Swedes had ≥ 3 sibling(s) and parent(s) with diabetes, i.e., FH++. Irrespective of family size, prediabetes and diabetes increased with family burden (FH− 29.4%; FH+ 38.8%; FH++ 61.7%) without significant differences across ethnicities. With increasing level of family burden, insulin secretion rather than insulin action decreased. Individuals with a combination of ≥ 3 siblings and parents with diabetes presented with the lowest levels of insulin secretion. Conclusions: The Iraqi immigrant population often present with a strong familial burden of type 2 diabetes with the worst glycemic control and highest diabetes risk in individuals with ≥ 3 siblings and parents with diabetes. Our data show that in a population still free from diabetes familial burden influences insulin secretion to a higher degree than insulin action and may be a logical target for intervention.</p>}},
author = {{Bennet, Louise and Franks, Paul W. and Zöller, Bengt and Groop, Leif}},
issn = {{0940-5429}},
keywords = {{Family history of diabetes; Insulin action; Insulin secretion; Middle East; Type 2 diabetes}},
language = {{eng}},
number = {{3}},
pages = {{233--242}},
publisher = {{Springer}},
series = {{Acta Diabetologica}},
title = {{Family history of diabetes and its relationship with insulin secretion and insulin sensitivity in Iraqi immigrants and native Swedes : a population-based cohort study}},
url = {{http://dx.doi.org/10.1007/s00592-017-1088-5}},
doi = {{10.1007/s00592-017-1088-5}},
volume = {{55}},
year = {{2018}},
}