Selectively bred rodent models for studying the etiology of type 2 diabetes : Goto-Kakizaki rats and Oikawa-Nagao mice
Nagao, Mototsugu LU ; Asai, Akira LU ; Eliasson, Lena LU
and Oikawa, Shinichi
(2023)
In Endocrine Journal
70(1).
p.19-30
- Abstract
Type 2 diabetes (T2D) is a polygenic disease and studies to understand the etiology of the disease have required selectively bred animal models with polygenic background. In this review, we present two models; the Goto-Kakizaki (GK) rat and the Oikawa-Nagao Diabetes-Prone (ON-DP) and Diabetes-Resistant (ON-DR) mouse. The GK rat was developed by continuous selective breeding for glucose tolerance from the outbred Wistar rat around 50 years ago. The main cause of spontaneous hyperglycemia in this model is insulin secretion deficiency from pancreatic β-cells and mild insulin resistance in insulin target organs. A disadvantage of the GK rat is that environmental factors have not been considered in the selective breeding. Hence, the GK rat... (More)
Type 2 diabetes (T2D) is a polygenic disease and studies to understand the etiology of the disease have required selectively bred animal models with polygenic background. In this review, we present two models; the Goto-Kakizaki (GK) rat and the Oikawa-Nagao Diabetes-Prone (ON-DP) and Diabetes-Resistant (ON-DR) mouse. The GK rat was developed by continuous selective breeding for glucose tolerance from the outbred Wistar rat around 50 years ago. The main cause of spontaneous hyperglycemia in this model is insulin secretion deficiency from pancreatic β-cells and mild insulin resistance in insulin target organs. A disadvantage of the GK rat is that environmental factors have not been considered in the selective breeding. Hence, the GK rat may not be suitable for elucidating predisposition to diabetes under certain environmental conditions, such as a high-fat diet. Therefore, we recently established two mouse lines with different susceptibilities to dietinduced diabetes, which are prone and resistant to the development of diabetes, designated as the ON-DP and ON-DR mouse, respectively. The two ON mouse lines were established by continuous selective breeding for inferior and superior glucose tolerance after high-fat diet feeding in hybrid mice of three inbred strains. Studies of phenotypic differences between ON-DP and ON-DR mice and their underlying molecular mechanisms will shed light on predisposing factors for the development of T2D in the modern obesogenic environment. This review summarizes the background and the phenotypic differences and similarities of GK rats and ON mice and highlights the advantages of using selectively bred rodent models in diabetes research.
(Less)
- author
- Nagao, Mototsugu
LU
; Asai, Akira
LU
; Eliasson, Lena
LU
and Oikawa, Shinichi
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Goto-Kakizaki rats, Oikawa-Nagao mice, Type 2 diabetes, β-cells
- in
- Endocrine Journal
- volume
- 70
- issue
- 1
- pages
- 12 pages
- publisher
- Japan Endocrine Society
- external identifiers
-
- scopus:85147095207
- pmid:36477370
- ISSN
- 0918-8959
- DOI
- 10.1507/endocrj.EJ22-0253
- language
- English
- LU publication?
- yes
- id
- b4a9a86b-6882-4c2c-8592-f711a377fe94
- date added to LUP
- 2023-02-10 15:38:53
- date last changed
- 2024-06-13 04:41:41
@article{b4a9a86b-6882-4c2c-8592-f711a377fe94,
abstract = {{<p>Type 2 diabetes (T2D) is a polygenic disease and studies to understand the etiology of the disease have required selectively bred animal models with polygenic background. In this review, we present two models; the Goto-Kakizaki (GK) rat and the Oikawa-Nagao Diabetes-Prone (ON-DP) and Diabetes-Resistant (ON-DR) mouse. The GK rat was developed by continuous selective breeding for glucose tolerance from the outbred Wistar rat around 50 years ago. The main cause of spontaneous hyperglycemia in this model is insulin secretion deficiency from pancreatic β-cells and mild insulin resistance in insulin target organs. A disadvantage of the GK rat is that environmental factors have not been considered in the selective breeding. Hence, the GK rat may not be suitable for elucidating predisposition to diabetes under certain environmental conditions, such as a high-fat diet. Therefore, we recently established two mouse lines with different susceptibilities to dietinduced diabetes, which are prone and resistant to the development of diabetes, designated as the ON-DP and ON-DR mouse, respectively. The two ON mouse lines were established by continuous selective breeding for inferior and superior glucose tolerance after high-fat diet feeding in hybrid mice of three inbred strains. Studies of phenotypic differences between ON-DP and ON-DR mice and their underlying molecular mechanisms will shed light on predisposing factors for the development of T2D in the modern obesogenic environment. This review summarizes the background and the phenotypic differences and similarities of GK rats and ON mice and highlights the advantages of using selectively bred rodent models in diabetes research.</p>}},
author = {{Nagao, Mototsugu and Asai, Akira and Eliasson, Lena and Oikawa, Shinichi}},
issn = {{0918-8959}},
keywords = {{Goto-Kakizaki rats; Oikawa-Nagao mice; Type 2 diabetes; β-cells}},
language = {{eng}},
number = {{1}},
pages = {{19--30}},
publisher = {{Japan Endocrine Society}},
series = {{Endocrine Journal}},
title = {{Selectively bred rodent models for studying the etiology of type 2 diabetes : Goto-Kakizaki rats and Oikawa-Nagao mice}},
url = {{http://dx.doi.org/10.1507/endocrj.EJ22-0253}},
doi = {{10.1507/endocrj.EJ22-0253}},
volume = {{70}},
year = {{2023}},
}