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Acute plateletpheresis and aprotinin reduces the need for blood transfusion following Ross operation.

Al-Rashidi, Faleh; Bhat, Misha LU ; Pierre, Leif LU and Koul, Bansi LU (2007) In Interactive Cardiovascular and Thoracic Surgery 6(5). p.618-622
Abstract
The effect of acute intraoperative plateletpheresis (25% platelet yield) in combination with intraoperative low-dose aprotinin (2 million units) on blood conservation was investigated in 18 young adult patients undergoing elective Ross operation. The results were compared with a group of 19 similar patients without plateletpheresis (control group). The hematological and coagulation parameters at admission and discharge were statistically similar in both groups. The total blood product transfusion requirements were significantly reduced in the plateletpheresis group compared with the control group (3.2 units and 5.1 units, respectively, P=0.036). The total blood donor exposure was also reduced significantly in the plateletpheresis group... (More)
The effect of acute intraoperative plateletpheresis (25% platelet yield) in combination with intraoperative low-dose aprotinin (2 million units) on blood conservation was investigated in 18 young adult patients undergoing elective Ross operation. The results were compared with a group of 19 similar patients without plateletpheresis (control group). The hematological and coagulation parameters at admission and discharge were statistically similar in both groups. The total blood product transfusion requirements were significantly reduced in the plateletpheresis group compared with the control group (3.2 units and 5.1 units, respectively, P=0.036). The total blood donor exposure was also reduced significantly in the plateletpheresis group compared with the control group (3.2 and 6.9 donors/patient, respectively, P<0.001). The direct costs for the hospital for the plateletpheresis procedure, including costs for all blood products, were similar to those for blood products alone in the control group. In summary, acute plateletpheresis in combination with low-dose aprotinin significantly reduces the blood product transfusions and blood donor exposures following the Ross operation; the treatment is cost-effective. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
in
Interactive Cardiovascular and Thoracic Surgery
volume
6
issue
5
pages
618 - 622
publisher
European Association of Cardio-Thoracic Surgery
external identifiers
  • scopus:34848922384
ISSN
1569-9285
language
English
LU publication?
no
id
b4bcfe3e-e9bd-41d6-bd0a-32b825fae753 (old id 607134)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17670731&dopt=Abstract
date added to LUP
2008-01-22 13:25:46
date last changed
2018-05-29 12:20:26
@article{b4bcfe3e-e9bd-41d6-bd0a-32b825fae753,
  abstract     = {The effect of acute intraoperative plateletpheresis (25% platelet yield) in combination with intraoperative low-dose aprotinin (2 million units) on blood conservation was investigated in 18 young adult patients undergoing elective Ross operation. The results were compared with a group of 19 similar patients without plateletpheresis (control group). The hematological and coagulation parameters at admission and discharge were statistically similar in both groups. The total blood product transfusion requirements were significantly reduced in the plateletpheresis group compared with the control group (3.2 units and 5.1 units, respectively, P=0.036). The total blood donor exposure was also reduced significantly in the plateletpheresis group compared with the control group (3.2 and 6.9 donors/patient, respectively, P&lt;0.001). The direct costs for the hospital for the plateletpheresis procedure, including costs for all blood products, were similar to those for blood products alone in the control group. In summary, acute plateletpheresis in combination with low-dose aprotinin significantly reduces the blood product transfusions and blood donor exposures following the Ross operation; the treatment is cost-effective.},
  author       = {Al-Rashidi, Faleh and Bhat, Misha and Pierre, Leif and Koul, Bansi},
  issn         = {1569-9285},
  language     = {eng},
  month        = {07},
  number       = {5},
  pages        = {618--622},
  publisher    = {European Association of Cardio-Thoracic Surgery},
  series       = {Interactive Cardiovascular and Thoracic Surgery},
  title        = {Acute plateletpheresis and aprotinin reduces the need for blood transfusion following Ross operation.},
  volume       = {6},
  year         = {2007},
}