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Antileishmanial metabolites from Lantana balansae

Maldonado, Eliana M. LU ; Salamanca, Efrain; Giménez, Alberto and Sterner, Olov LU (2016) In Brazilian Journal of Pharmacognosy 26(2). p.180-183
Abstract

Eleven compounds, 12-oxo-phytodienoic acid (1), persicogenin (2), eriodictyol 3ʹ4ʹ,7-trimethyl ether (3), phytol (4), spathulenol (5), 4-hydroxycinnamic acid (6), onopordin (7), 5,8,4ʹ-trihydroxy-7,3ʹ-dimethoxyflavone (8), quercetin (9), jaceosidin (10), and 8-hydroxyluteolin (11), were isolated from an ethanol extract of Lantana balansae Briq., Verbenaceae, that was found to possess antileishmanial activ-ity. The structures of the compounds were determined by NMR spectroscopy and HR mass spectrometry, and 1, 2, 3, 7, 8 and 9 were investigated for antiprotozoal activity toward promastigotes of Leishmania amazonensis and Leishmania braziliensis. Compound 1 was shown to be the most potent, with the IC50 values 2.0µM toward L.... (More)

Eleven compounds, 12-oxo-phytodienoic acid (1), persicogenin (2), eriodictyol 3ʹ4ʹ,7-trimethyl ether (3), phytol (4), spathulenol (5), 4-hydroxycinnamic acid (6), onopordin (7), 5,8,4ʹ-trihydroxy-7,3ʹ-dimethoxyflavone (8), quercetin (9), jaceosidin (10), and 8-hydroxyluteolin (11), were isolated from an ethanol extract of Lantana balansae Briq., Verbenaceae, that was found to possess antileishmanial activ-ity. The structures of the compounds were determined by NMR spectroscopy and HR mass spectrometry, and 1, 2, 3, 7, 8 and 9 were investigated for antiprotozoal activity toward promastigotes of Leishmania amazonensis and Leishmania braziliensis. Compound 1 was shown to be the most potent, with the IC50 values 2.0µM toward L. amazonensis and 0.68µM toward L. braziliensis, although less potent than the positive control Amphotericin B. All compounds have been reported previously, but this is the first report of the isolation of a cyclopentenone fatty acid (1) and flavanones (2 and 3) from a Lantana species.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
12-oxo-phytodienoic acid, Flavonoids, L. braziliensis, Lantana balansae, Leishmania amazonensis
in
Brazilian Journal of Pharmacognosy
volume
26
issue
2
pages
4 pages
publisher
Sociedade Brasileira de Farmacognosia
external identifiers
  • scopus:84963727382
ISSN
0102-695X
DOI
10.1016/j.bjp.2015.11.007
language
English
LU publication?
yes
id
b4ca468c-b458-4948-9d5c-27ba4b82fe43
date added to LUP
2016-09-22 08:12:57
date last changed
2017-01-01 08:34:43
@article{b4ca468c-b458-4948-9d5c-27ba4b82fe43,
  abstract     = {<p>Eleven compounds, 12-oxo-phytodienoic acid (1), persicogenin (2), eriodictyol 3ʹ4ʹ,7-trimethyl ether (3), phytol (4), spathulenol (5), 4-hydroxycinnamic acid (6), onopordin (7), 5,8,4ʹ-trihydroxy-7,3ʹ-dimethoxyflavone (8), quercetin (9), jaceosidin (10), and 8-hydroxyluteolin (11), were isolated from an ethanol extract of Lantana balansae Briq., Verbenaceae, that was found to possess antileishmanial activ-ity. The structures of the compounds were determined by NMR spectroscopy and HR mass spectrometry, and 1, 2, 3, 7, 8 and 9 were investigated for antiprotozoal activity toward promastigotes of Leishmania amazonensis and Leishmania braziliensis. Compound 1 was shown to be the most potent, with the IC<sub>50</sub> values 2.0µM toward L. amazonensis and 0.68µM toward L. braziliensis, although less potent than the positive control Amphotericin B. All compounds have been reported previously, but this is the first report of the isolation of a cyclopentenone fatty acid (1) and flavanones (2 and 3) from a Lantana species.</p>},
  author       = {Maldonado, Eliana M. and Salamanca, Efrain and Giménez, Alberto and Sterner, Olov},
  issn         = {0102-695X},
  keyword      = {12-oxo-phytodienoic acid,Flavonoids,L. braziliensis,Lantana balansae,Leishmania amazonensis},
  language     = {eng},
  month        = {01},
  number       = {2},
  pages        = {180--183},
  publisher    = {Sociedade Brasileira de Farmacognosia},
  series       = {Brazilian Journal of Pharmacognosy},
  title        = {Antileishmanial metabolites from Lantana balansae},
  url          = {http://dx.doi.org/10.1016/j.bjp.2015.11.007},
  volume       = {26},
  year         = {2016},
}