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Association between Atrial Fibrillatory Rate and Heart Rate Variability in Patients with Atrial Fibrillation and Congestive Heart Failure

Corino, Valentina D. A.; Cygankiewicz, Iwona; Mainardi, Luca T.; Stridh, Martin LU ; Vasquez, Rafael; de Luna, Antonio Bayes; Holmqvist, Fredrik LU ; Zareba, Wojciech and Platonov, Pyotr LU (2013) In Annals of Noninvasive Electrocardiology 18(1). p.41-50
Abstract
Background Even if atrial fibrillatory rate (AFR) has been related to clinical outcome in patients with atrial fibrillation (AF), its relation with ventricular response has not been deeply studied. The aim of this study was to investigate the relation between AFR and RR series variability in patients with AF. Methods Twenty-minute electrocardiograms in orthogonal leads were processed to extract AFR, using spatiotemporal QRST cancellation and time frequency analysis, and RR series in 127 patients (age 69 +/- 11 years) with congestive heart failure (NYHA IIIII) enrolled in the MUSIC study (MUerte Subita en Insufficiencia Cardiaca). Heart rate variability and irregularity were assessed by time domain parameters and entropy-based indices,... (More)
Background Even if atrial fibrillatory rate (AFR) has been related to clinical outcome in patients with atrial fibrillation (AF), its relation with ventricular response has not been deeply studied. The aim of this study was to investigate the relation between AFR and RR series variability in patients with AF. Methods Twenty-minute electrocardiograms in orthogonal leads were processed to extract AFR, using spatiotemporal QRST cancellation and time frequency analysis, and RR series in 127 patients (age 69 +/- 11 years) with congestive heart failure (NYHA IIIII) enrolled in the MUSIC study (MUerte Subita en Insufficiencia Cardiaca). Heart rate variability and irregularity were assessed by time domain parameters and entropy-based indices, respectively and their correlation with AFR investigated. Results Variability measures seem not to be related to AFR, while irregularity measures do. A significant correlation between AFR and variability parameters of heart rate variability during AF was found only in patients not treated with antiarrhythmics drugs (correlation = 0.56 P < 0.05 for pNN50), while this correlation was lost in patients taking rate- or rhythm-control drugs. A significant positive correlation between AFR and indices of RR irregularity was found, showing that a higher AFR is related to a less organized RR series (correlation = 0.33 P < 0.05 for regularity index for all patients, correlation increased in subgroups of patients treated with the same drug). Conclusions These results suggest that a higher AFR is associated with a higher degree of irregularity of ventricular response that is observed regardless of the use of rate-controlling drugs. Ann Noninvasive Electrocardiol 2013;18(1):41-50 (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
atrial fibrillation, frequency, time domain parameters, approximate, entropy, regularity, congestive heart failure
in
Annals of Noninvasive Electrocardiology
volume
18
issue
1
pages
41 - 50
publisher
Wiley-Blackwell
external identifiers
  • wos:000314151100005
  • scopus:84873045891
ISSN
1082-720X
DOI
10.1111/anec.12019
language
English
LU publication?
yes
id
b4d11416-cc87-42f3-b1de-6be641a38453 (old id 3590761)
date added to LUP
2013-03-20 14:27:30
date last changed
2019-03-05 01:12:43
@article{b4d11416-cc87-42f3-b1de-6be641a38453,
  abstract     = {Background Even if atrial fibrillatory rate (AFR) has been related to clinical outcome in patients with atrial fibrillation (AF), its relation with ventricular response has not been deeply studied. The aim of this study was to investigate the relation between AFR and RR series variability in patients with AF. Methods Twenty-minute electrocardiograms in orthogonal leads were processed to extract AFR, using spatiotemporal QRST cancellation and time frequency analysis, and RR series in 127 patients (age 69 +/- 11 years) with congestive heart failure (NYHA IIIII) enrolled in the MUSIC study (MUerte Subita en Insufficiencia Cardiaca). Heart rate variability and irregularity were assessed by time domain parameters and entropy-based indices, respectively and their correlation with AFR investigated. Results Variability measures seem not to be related to AFR, while irregularity measures do. A significant correlation between AFR and variability parameters of heart rate variability during AF was found only in patients not treated with antiarrhythmics drugs (correlation = 0.56 P &lt; 0.05 for pNN50), while this correlation was lost in patients taking rate- or rhythm-control drugs. A significant positive correlation between AFR and indices of RR irregularity was found, showing that a higher AFR is related to a less organized RR series (correlation = 0.33 P &lt; 0.05 for regularity index for all patients, correlation increased in subgroups of patients treated with the same drug). Conclusions These results suggest that a higher AFR is associated with a higher degree of irregularity of ventricular response that is observed regardless of the use of rate-controlling drugs. Ann Noninvasive Electrocardiol 2013;18(1):41-50},
  author       = {Corino, Valentina D. A. and Cygankiewicz, Iwona and Mainardi, Luca T. and Stridh, Martin and Vasquez, Rafael and de Luna, Antonio Bayes and Holmqvist, Fredrik and Zareba, Wojciech and Platonov, Pyotr},
  issn         = {1082-720X},
  keyword      = {atrial fibrillation,frequency,time domain parameters,approximate,entropy,regularity,congestive heart failure},
  language     = {eng},
  number       = {1},
  pages        = {41--50},
  publisher    = {Wiley-Blackwell},
  series       = {Annals of Noninvasive Electrocardiology},
  title        = {Association between Atrial Fibrillatory Rate and Heart Rate Variability in Patients with Atrial Fibrillation and Congestive Heart Failure},
  url          = {http://dx.doi.org/10.1111/anec.12019},
  volume       = {18},
  year         = {2013},
}