Evidence-based evaluation of magnetic resonance imaging as a diagnostic tool in dementia workup
(2005) In Topics in Magnetic Resonance Imaging 16(6). p.427-437- Abstract
- BACKGROUND: The diagnostic utility of magnetic resonance imaging in dementia workups has increased recently. The basic use is to exclude space-occupying processes in the brain. However, magnetic resonance imaging offers major opportunities for studying atrophy of specific brain areas. A great interest has been put in whether atrophy in the medial temporal lobe can serve as an early diagnostic marker for Alzheimer disease.
METHODS AND RESULTS: In this evaluation, we used evidence-based techniques and reviewed more than 400 articles that address this issue. Our main finding is that a variety of methods in studying brain areas were used, and this made it difficult to extract conclusive information in a systematic way.
... (More) - BACKGROUND: The diagnostic utility of magnetic resonance imaging in dementia workups has increased recently. The basic use is to exclude space-occupying processes in the brain. However, magnetic resonance imaging offers major opportunities for studying atrophy of specific brain areas. A great interest has been put in whether atrophy in the medial temporal lobe can serve as an early diagnostic marker for Alzheimer disease.
METHODS AND RESULTS: In this evaluation, we used evidence-based techniques and reviewed more than 400 articles that address this issue. Our main finding is that a variety of methods in studying brain areas were used, and this made it difficult to extract conclusive information in a systematic way.
CONCLUSION: However, we were able to conclude that atrophy of the hippocampus can distinguish patients with Alzheimer disease from healthy subjects, but there was a lack of evidence because of insufficient studies concerning the usefulness of medial temporal lobe atrophy as a diagnostic marker in a more general setting. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/949832
- author
- Wahlund, Lars-Olof ; Almkvist, Ove ; Blennow, Kaj ; Engedahl, Knut ; Johanson, Aki LU ; Waldemar, Gunhild and Wolf, Henrike
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Dementia workup, medial temporal lobe, Alzheimer disease, specificity, sensitivity, likelihood ratios, evidence-based medicine, magnetic resonance imaging, diagnosis
- in
- Topics in Magnetic Resonance Imaging
- volume
- 16
- issue
- 6
- pages
- 427 - 437
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- scopus:33750689880
- ISSN
- 0899-3459
- DOI
- 10.1097/01.rmr.0000245463.36148.12
- language
- English
- LU publication?
- yes
- additional info
- PMID: 17088692 [PubMed - indexed for MEDLINE]
- id
- b4ec9a37-1997-4f64-9b09-6864949514d7 (old id 949832)
- date added to LUP
- 2016-04-01 15:32:47
- date last changed
- 2025-04-04 15:12:01
@article{b4ec9a37-1997-4f64-9b09-6864949514d7,
abstract = {{BACKGROUND: The diagnostic utility of magnetic resonance imaging in dementia workups has increased recently. The basic use is to exclude space-occupying processes in the brain. However, magnetic resonance imaging offers major opportunities for studying atrophy of specific brain areas. A great interest has been put in whether atrophy in the medial temporal lobe can serve as an early diagnostic marker for Alzheimer disease. <br/><br>
METHODS AND RESULTS: In this evaluation, we used evidence-based techniques and reviewed more than 400 articles that address this issue. Our main finding is that a variety of methods in studying brain areas were used, and this made it difficult to extract conclusive information in a systematic way. <br/><br>
CONCLUSION: However, we were able to conclude that atrophy of the hippocampus can distinguish patients with Alzheimer disease from healthy subjects, but there was a lack of evidence because of insufficient studies concerning the usefulness of medial temporal lobe atrophy as a diagnostic marker in a more general setting.}},
author = {{Wahlund, Lars-Olof and Almkvist, Ove and Blennow, Kaj and Engedahl, Knut and Johanson, Aki and Waldemar, Gunhild and Wolf, Henrike}},
issn = {{0899-3459}},
keywords = {{Dementia workup; medial temporal lobe; Alzheimer disease; specificity; sensitivity; likelihood ratios; evidence-based medicine; magnetic resonance imaging; diagnosis}},
language = {{eng}},
number = {{6}},
pages = {{427--437}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{Topics in Magnetic Resonance Imaging}},
title = {{Evidence-based evaluation of magnetic resonance imaging as a diagnostic tool in dementia workup}},
url = {{http://dx.doi.org/10.1097/01.rmr.0000245463.36148.12}},
doi = {{10.1097/01.rmr.0000245463.36148.12}},
volume = {{16}},
year = {{2005}},
}