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Acute Cardiovascular Effects of Hydrotreated Vegetable Oil Exhaust

Marc-Derrien, Youna ; Gren, Louise LU ; Dierschke, Katrin LU ; Albin, Maria LU ; Gudmundsson, Anders LU ; Wierzbicka, Aneta LU orcid and Sandberg, Frida LU (2022) In Frontiers in Physiology 13.
Abstract

Ambient air pollution is recognized as a key risk factor for cardiovascular morbidity and mortality contributing to the global disease burden. The use of renewable diesel fuels, such as hydrotreated vegetable oil (HVO), have increased in recent years and its impact on human health are not completely known. The present study investigated changes in cardiovascular tone in response to exposure to diluted HVO exhaust. The study participants, 19 healthy volunteers, were exposed in a chamber on four separate occasions for 3 h and in a randomized order to: (1) HVO exhaust from a wheel loader without exhaust aftertreatment, (2) HVO exhaust from a wheel loader with an aftertreatment system, (3) clean air enriched with dry NaCl salt particles,... (More)

Ambient air pollution is recognized as a key risk factor for cardiovascular morbidity and mortality contributing to the global disease burden. The use of renewable diesel fuels, such as hydrotreated vegetable oil (HVO), have increased in recent years and its impact on human health are not completely known. The present study investigated changes in cardiovascular tone in response to exposure to diluted HVO exhaust. The study participants, 19 healthy volunteers, were exposed in a chamber on four separate occasions for 3 h and in a randomized order to: (1) HVO exhaust from a wheel loader without exhaust aftertreatment, (2) HVO exhaust from a wheel loader with an aftertreatment system, (3) clean air enriched with dry NaCl salt particles, and (4) clean air. Synchronized electrocardiogram (ECG) and photoplethysmogram (PPG) signals were recorded throughout the exposure sessions. Pulse decomposition analysis (PDA) was applied to characterize PPG pulse morphology, and heart rate variability (HRV) indexes as well as pulse transit time (PTT) indexes were computed. Relative changes of PDA features, HRV features and PTT features at 1, 2, and 3 h after onset of the exposure was obtained for each participant and exposure session. The PDA index A13, reflecting vascular compliance, increased significantly in both HVO exposure sessions but not in the clean air or NaCl exposure sessions. However, the individual variation was large and the differences between exposure sessions were not statistically significant.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Frontiers in Physiology
volume
13
article number
828311
publisher
Frontiers Media S. A.
external identifiers
  • scopus:85127233638
  • pmid:35350690
ISSN
1664-042X
DOI
10.3389/fphys.2022.828311
project
Health effects on humans of emissions from vehicles operated with biodiesel
language
English
LU publication?
yes
additional info
Copyright © 2022 Marc-Derrien, Gren, Dierschke, Albin, Gudmundsson, Wierzbicka and Sandberg.
id
b5087ad2-3de6-4ed6-998a-751d1e227655
date added to LUP
2022-04-01 14:07:36
date last changed
2025-02-17 01:12:09
@article{b5087ad2-3de6-4ed6-998a-751d1e227655,
  abstract     = {{<p>Ambient air pollution is recognized as a key risk factor for cardiovascular morbidity and mortality contributing to the global disease burden. The use of renewable diesel fuels, such as hydrotreated vegetable oil (HVO), have increased in recent years and its impact on human health are not completely known. The present study investigated changes in cardiovascular tone in response to exposure to diluted HVO exhaust. The study participants, 19 healthy volunteers, were exposed in a chamber on four separate occasions for 3 h and in a randomized order to: (1) HVO exhaust from a wheel loader without exhaust aftertreatment, (2) HVO exhaust from a wheel loader with an aftertreatment system, (3) clean air enriched with dry NaCl salt particles, and (4) clean air. Synchronized electrocardiogram (ECG) and photoplethysmogram (PPG) signals were recorded throughout the exposure sessions. Pulse decomposition analysis (PDA) was applied to characterize PPG pulse morphology, and heart rate variability (HRV) indexes as well as pulse transit time (PTT) indexes were computed. Relative changes of PDA features, HRV features and PTT features at 1, 2, and 3 h after onset of the exposure was obtained for each participant and exposure session. The PDA index A13, reflecting vascular compliance, increased significantly in both HVO exposure sessions but not in the clean air or NaCl exposure sessions. However, the individual variation was large and the differences between exposure sessions were not statistically significant.</p>}},
  author       = {{Marc-Derrien, Youna and Gren, Louise and Dierschke, Katrin and Albin, Maria and Gudmundsson, Anders and Wierzbicka, Aneta and Sandberg, Frida}},
  issn         = {{1664-042X}},
  language     = {{eng}},
  publisher    = {{Frontiers Media S. A.}},
  series       = {{Frontiers in Physiology}},
  title        = {{Acute Cardiovascular Effects of Hydrotreated Vegetable Oil Exhaust}},
  url          = {{http://dx.doi.org/10.3389/fphys.2022.828311}},
  doi          = {{10.3389/fphys.2022.828311}},
  volume       = {{13}},
  year         = {{2022}},
}