Impulse oscillometry indices in relation to respiratory symptoms and spirometry in the Swedish Cardiopulmonary Bioimage Study
(2023) In ERJ open research 9(5).- Abstract
Background Impulse oscillometry (IOS) is sensitive in detecting lung function impairment. In small studies, impaired IOS relates better to respiratory symptoms than spirometry. We studied how IOS related to spirometry and respiratory symptoms in a large population of individuals (n=10 360) in a cross-sectional analysis. Methods Normal values for IOS and spirometry were defined in healthy, never-smoking individuals, aged 50–64 years, from the Swedish CArdioPulmonary bioImage Study (n=3664 for IOS and 3608 for spirometry). For IOS, abnormal values for resistance at 5 Hz (R5) and at 20 Hz and area of reactance were defined using the 95th percentile. Abnormal reactance at 5 Hz for IOS and abnormal conventional spirometry indices... (More)
Background Impulse oscillometry (IOS) is sensitive in detecting lung function impairment. In small studies, impaired IOS relates better to respiratory symptoms than spirometry. We studied how IOS related to spirometry and respiratory symptoms in a large population of individuals (n=10 360) in a cross-sectional analysis. Methods Normal values for IOS and spirometry were defined in healthy, never-smoking individuals, aged 50–64 years, from the Swedish CArdioPulmonary bioImage Study (n=3664 for IOS and 3608 for spirometry). For IOS, abnormal values for resistance at 5 Hz (R5) and at 20 Hz and area of reactance were defined using the 95th percentile. Abnormal reactance at 5 Hz for IOS and abnormal conventional spirometry indices (forced expiratory volume in 1 s (FEV1), forced and slow vital capacity and their ratios) were defined using the 5th percentile. Results Abnormal IOS parameters were found in 16% of individuals and were associated with increased odds ratios for nearly all respiratory symptoms when adjusted for age, gender and smoking. In individuals with normal spirometry, abnormal IOS resistance was related to cough and dyspnoea, while abnormal reactance was related to wheeze. In these individuals, the combination of abnormal R5 with abnormal reactance resulted in approximately two-fold higher likelihood for having cough, chronic bronchitis and dyspnoea, even when further adjusting for FEV1, expressed as % predicted. Conclusions Abnormal IOS is related to increased respiratory burden in middle-aged individuals with normal spirometry, especially when resistance and reactance parameters are combined. The different relationships between respiratory symptoms and reactance and resistance warrant further research.
(Less)
- author
- Qvarnström, Björn ; Engström, Gunnar LU ; Frantz, Sophia LU ; Zhou, Xingwu ; Zaigham, Suneela LU ; Sundström, Johan ; Janson, Christer ; Wollmer, Per LU and Malinovschi, Andrei
- organization
- publishing date
- 2023-09-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- ERJ open research
- volume
- 9
- issue
- 5
- article number
- 00736-2022
- publisher
- European Respiratory Society
- external identifiers
-
- pmid:37753278
- scopus:85172991351
- ISSN
- 2312-0541
- DOI
- 10.1183/23120541.00736-2022
- language
- English
- LU publication?
- yes
- id
- b55eae94-bbb8-4e5a-a227-9e923ca6c9a8
- date added to LUP
- 2023-12-18 09:45:17
- date last changed
- 2024-04-16 21:56:54
@article{b55eae94-bbb8-4e5a-a227-9e923ca6c9a8,
abstract = {{<p>Background Impulse oscillometry (IOS) is sensitive in detecting lung function impairment. In small studies, impaired IOS relates better to respiratory symptoms than spirometry. We studied how IOS related to spirometry and respiratory symptoms in a large population of individuals (n=10 360) in a cross-sectional analysis. Methods Normal values for IOS and spirometry were defined in healthy, never-smoking individuals, aged 50–64 years, from the Swedish CArdioPulmonary bioImage Study (n=3664 for IOS and 3608 for spirometry). For IOS, abnormal values for resistance at 5 Hz (R<sub>5</sub>) and at 20 Hz and area of reactance were defined using the 95th percentile. Abnormal reactance at 5 Hz for IOS and abnormal conventional spirometry indices (forced expiratory volume in 1 s (FEV<sub>1</sub>), forced and slow vital capacity and their ratios) were defined using the 5th percentile. Results Abnormal IOS parameters were found in 16% of individuals and were associated with increased odds ratios for nearly all respiratory symptoms when adjusted for age, gender and smoking. In individuals with normal spirometry, abnormal IOS resistance was related to cough and dyspnoea, while abnormal reactance was related to wheeze. In these individuals, the combination of abnormal R<sub>5</sub> with abnormal reactance resulted in approximately two-fold higher likelihood for having cough, chronic bronchitis and dyspnoea, even when further adjusting for FEV<sub>1</sub>, expressed as % predicted. Conclusions Abnormal IOS is related to increased respiratory burden in middle-aged individuals with normal spirometry, especially when resistance and reactance parameters are combined. The different relationships between respiratory symptoms and reactance and resistance warrant further research.</p>}},
author = {{Qvarnström, Björn and Engström, Gunnar and Frantz, Sophia and Zhou, Xingwu and Zaigham, Suneela and Sundström, Johan and Janson, Christer and Wollmer, Per and Malinovschi, Andrei}},
issn = {{2312-0541}},
language = {{eng}},
month = {{09}},
number = {{5}},
publisher = {{European Respiratory Society}},
series = {{ERJ open research}},
title = {{Impulse oscillometry indices in relation to respiratory symptoms and spirometry in the Swedish Cardiopulmonary Bioimage Study}},
url = {{http://dx.doi.org/10.1183/23120541.00736-2022}},
doi = {{10.1183/23120541.00736-2022}},
volume = {{9}},
year = {{2023}},
}