IL-1β modulation of spontaneous autoimmune diabetes and thyroiditis in the BB rat
(1990) In Journal of Immunology 144(10). p.3784-3788- Abstract
Long term effects of in vivo treatment with human rIL-1β on diabetogenesis and thyroid disease were determined in the Biobreeding rat. Administration of high dose (10 μg/kg) IL-1β accelerated the onset of insulin-dependent diabetes mellitus compared to saline-injected controls. High dose treatment resulted in goiter development, pronounced LT, reduced serum T4 levels, and overall growth reduction. In contrast, low dose IL-1β (0.5 μg/kg) administration significantly reduced the frequency of insulin-dependent diabetes mellitus (48%) compared to placebo (86%) and high dose IL-1β (93%) treatment groups. Rats protected by low dose IL-1β had unaffected growth rates and minimal to no pancreatic and thyroid pathology. Our results demonstrate... (More)
Long term effects of in vivo treatment with human rIL-1β on diabetogenesis and thyroid disease were determined in the Biobreeding rat. Administration of high dose (10 μg/kg) IL-1β accelerated the onset of insulin-dependent diabetes mellitus compared to saline-injected controls. High dose treatment resulted in goiter development, pronounced LT, reduced serum T4 levels, and overall growth reduction. In contrast, low dose IL-1β (0.5 μg/kg) administration significantly reduced the frequency of insulin-dependent diabetes mellitus (48%) compared to placebo (86%) and high dose IL-1β (93%) treatment groups. Rats protected by low dose IL-1β had unaffected growth rates and minimal to no pancreatic and thyroid pathology. Our results demonstrate that exogenous administration of IL-1β modulates Biobreeding rat idiopathic autoimmune diabetes and thyroid disease in a dose-dependent manner.
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- author
- Wilson, C. A. ; Jacobs, C. ; Baker, P. ; Baskin, D. G. ; Dower, S. ; Lernmark, A. LU ; Toivola, B. ; Vertrees, S. and Wilson, D.
- organization
- publishing date
- 1990-06-08
- type
- Contribution to journal
- publication status
- published
- in
- Journal of Immunology
- volume
- 144
- issue
- 10
- pages
- 3784 - 3788
- publisher
- American Association of Immunologists
- external identifiers
-
- pmid:2332631
- scopus:0025337307
- ISSN
- 0022-1767
- language
- English
- LU publication?
- yes
- id
- b57a0e47-0246-4160-819f-c51515400cfc
- alternative location
- https://www.jimmunol.org/content/jimmunol/144/10/3784.full.pdf
- date added to LUP
- 2019-09-11 09:43:12
- date last changed
- 2024-03-13 08:18:30
@article{b57a0e47-0246-4160-819f-c51515400cfc, abstract = {{<p>Long term effects of in vivo treatment with human rIL-1β on diabetogenesis and thyroid disease were determined in the Biobreeding rat. Administration of high dose (10 μg/kg) IL-1β accelerated the onset of insulin-dependent diabetes mellitus compared to saline-injected controls. High dose treatment resulted in goiter development, pronounced LT, reduced serum T4 levels, and overall growth reduction. In contrast, low dose IL-1β (0.5 μg/kg) administration significantly reduced the frequency of insulin-dependent diabetes mellitus (48%) compared to placebo (86%) and high dose IL-1β (93%) treatment groups. Rats protected by low dose IL-1β had unaffected growth rates and minimal to no pancreatic and thyroid pathology. Our results demonstrate that exogenous administration of IL-1β modulates Biobreeding rat idiopathic autoimmune diabetes and thyroid disease in a dose-dependent manner.</p>}}, author = {{Wilson, C. A. and Jacobs, C. and Baker, P. and Baskin, D. G. and Dower, S. and Lernmark, A. and Toivola, B. and Vertrees, S. and Wilson, D.}}, issn = {{0022-1767}}, language = {{eng}}, month = {{06}}, number = {{10}}, pages = {{3784--3788}}, publisher = {{American Association of Immunologists}}, series = {{Journal of Immunology}}, title = {{IL-1β modulation of spontaneous autoimmune diabetes and thyroiditis in the BB rat}}, url = {{https://www.jimmunol.org/content/jimmunol/144/10/3784.full.pdf}}, volume = {{144}}, year = {{1990}}, }