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IL-1β modulation of spontaneous autoimmune diabetes and thyroiditis in the BB rat

Wilson, C. A. ; Jacobs, C. ; Baker, P. ; Baskin, D. G. ; Dower, S. ; Lernmark, A. LU orcid ; Toivola, B. ; Vertrees, S. and Wilson, D. (1990) In Journal of Immunology 144(10). p.3784-3788
Abstract

Long term effects of in vivo treatment with human rIL-1β on diabetogenesis and thyroid disease were determined in the Biobreeding rat. Administration of high dose (10 μg/kg) IL-1β accelerated the onset of insulin-dependent diabetes mellitus compared to saline-injected controls. High dose treatment resulted in goiter development, pronounced LT, reduced serum T4 levels, and overall growth reduction. In contrast, low dose IL-1β (0.5 μg/kg) administration significantly reduced the frequency of insulin-dependent diabetes mellitus (48%) compared to placebo (86%) and high dose IL-1β (93%) treatment groups. Rats protected by low dose IL-1β had unaffected growth rates and minimal to no pancreatic and thyroid pathology. Our results demonstrate... (More)

Long term effects of in vivo treatment with human rIL-1β on diabetogenesis and thyroid disease were determined in the Biobreeding rat. Administration of high dose (10 μg/kg) IL-1β accelerated the onset of insulin-dependent diabetes mellitus compared to saline-injected controls. High dose treatment resulted in goiter development, pronounced LT, reduced serum T4 levels, and overall growth reduction. In contrast, low dose IL-1β (0.5 μg/kg) administration significantly reduced the frequency of insulin-dependent diabetes mellitus (48%) compared to placebo (86%) and high dose IL-1β (93%) treatment groups. Rats protected by low dose IL-1β had unaffected growth rates and minimal to no pancreatic and thyroid pathology. Our results demonstrate that exogenous administration of IL-1β modulates Biobreeding rat idiopathic autoimmune diabetes and thyroid disease in a dose-dependent manner.

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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
in
Journal of Immunology
volume
144
issue
10
pages
3784 - 3788
publisher
American Association of Immunologists
external identifiers
  • scopus:0025337307
  • pmid:2332631
ISSN
0022-1767
language
English
LU publication?
yes
id
b57a0e47-0246-4160-819f-c51515400cfc
alternative location
https://www.jimmunol.org/content/jimmunol/144/10/3784.full.pdf
date added to LUP
2019-09-11 09:43:12
date last changed
2024-03-13 08:18:30
@article{b57a0e47-0246-4160-819f-c51515400cfc,
  abstract     = {{<p>Long term effects of in vivo treatment with human rIL-1β on diabetogenesis and thyroid disease were determined in the Biobreeding rat. Administration of high dose (10 μg/kg) IL-1β accelerated the onset of insulin-dependent diabetes mellitus compared to saline-injected controls. High dose treatment resulted in goiter development, pronounced LT, reduced serum T4 levels, and overall growth reduction. In contrast, low dose IL-1β (0.5 μg/kg) administration significantly reduced the frequency of insulin-dependent diabetes mellitus (48%) compared to placebo (86%) and high dose IL-1β (93%) treatment groups. Rats protected by low dose IL-1β had unaffected growth rates and minimal to no pancreatic and thyroid pathology. Our results demonstrate that exogenous administration of IL-1β modulates Biobreeding rat idiopathic autoimmune diabetes and thyroid disease in a dose-dependent manner.</p>}},
  author       = {{Wilson, C. A. and Jacobs, C. and Baker, P. and Baskin, D. G. and Dower, S. and Lernmark, A. and Toivola, B. and Vertrees, S. and Wilson, D.}},
  issn         = {{0022-1767}},
  language     = {{eng}},
  month        = {{06}},
  number       = {{10}},
  pages        = {{3784--3788}},
  publisher    = {{American Association of Immunologists}},
  series       = {{Journal of Immunology}},
  title        = {{IL-1β modulation of spontaneous autoimmune diabetes and thyroiditis in the BB rat}},
  url          = {{https://www.jimmunol.org/content/jimmunol/144/10/3784.full.pdf}},
  volume       = {{144}},
  year         = {{1990}},
}