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Metabolism of estrone sulfate by normal breast tissue : Influence of menopausal status and oral contraceptives

Söderqvist, Gunnar; Olsson, Håkan LU ; Wilking, Nils LU ; von Schoultz, Bo and Carlström, Kjell (1994) In Journal of Steroid Biochemistry and Molecular Biology 48(2-3). p.221-224
Abstract


The metabolism of [
3
H]estrone sulfate ([
3
H]E
1
S) was studied in normal breast tissue from 10 premenopausal women without oral contraceptives (OC), in 12 OC users and in 9 untreated postmenopausal women. [
3
H]E
1
S was converted into estrone ([
3
H]E
... (More)


The metabolism of [
3
H]estrone sulfate ([
3
H]E
1
S) was studied in normal breast tissue from 10 premenopausal women without oral contraceptives (OC), in 12 OC users and in 9 untreated postmenopausal women. [
3
H]E
1
S was converted into estrone ([
3
H]E
1
) and estradiol-17β ([
3
H]E
2
) by tissue samples from all three groups of women, with only minor formation of other unconjugated compounds. The rate of [
3
H]E
2
formation was significantly higher in premenopausal women without OC than in postmenopausal women. Among premenopausal women, OC users had a significantly lower rate of total hydrolysis and of [
3
H]E
1
formation than non-users. The rate of total hydrolysis of [
3
H]E
1
S in normal breast tissue from all three groups of women was similar to that in muscle, but the rate of [
3
H]E
2
formation was ten times higher. Both total hydrolysis rate and rate of [
3
H]E
2
formation were significantly lower in normal breast tissue than in breast carcinoma and in normal and neoplastic endometrium. The specific ability of normal breast tissue to convert E
1
S into the terminal biologically active estrogen E
2
may be important for estrogenic stimulation of the breast in subjects with low circulating E
2
levels. The lower rate of E
1
formation in OC users may reflect an inhibitory effect of the progestagen compound in such preparations.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Steroid Biochemistry and Molecular Biology
volume
48
issue
2-3
pages
4 pages
publisher
Elsevier
external identifiers
  • scopus:0028206648
ISSN
0960-0760
DOI
10.1016/0960-0760(94)90148-1
language
English
LU publication?
yes
id
b57f130b-54af-4b72-ad7c-84f235bcbd78
date added to LUP
2019-05-28 16:24:02
date last changed
2019-08-16 14:28:17
@article{b57f130b-54af-4b72-ad7c-84f235bcbd78,
  abstract     = {<p><br>
                            The metabolism of [<br>
                            <sup>3</sup><br>
                            H]estrone sulfate ([<br>
                            <sup>3</sup><br>
                            H]E<br>
                            <sub>1</sub><br>
                            S) was studied in normal breast tissue from 10 premenopausal women without oral contraceptives (OC), in 12 OC users and in 9 untreated postmenopausal women. [<br>
                            <sup>3</sup><br>
                            H]E<br>
                            <sub>1</sub><br>
                            S was converted into estrone ([<br>
                            <sup>3</sup><br>
                            H]E<br>
                            <sub>1</sub><br>
                            ) and estradiol-17β ([<br>
                            <sup>3</sup><br>
                            H]E<br>
                            <sub>2</sub><br>
                            ) by tissue samples from all three groups of women, with only minor formation of other unconjugated compounds. The rate of [<br>
                            <sup>3</sup><br>
                            H]E<br>
                            <sub>2</sub><br>
                             formation was significantly higher in premenopausal women without OC than in postmenopausal women. Among premenopausal women, OC users had a significantly lower rate of total hydrolysis and of [<br>
                            <sup>3</sup><br>
                            H]E<br>
                            <sub>1</sub><br>
                             formation than non-users. The rate of total hydrolysis of [<br>
                            <sup>3</sup><br>
                            H]E<br>
                            <sub>1</sub><br>
                            S in normal breast tissue from all three groups of women was similar to that in muscle, but the rate of [<br>
                            <sup>3</sup><br>
                            H]E<br>
                            <sub>2</sub><br>
                             formation was ten times higher. Both total hydrolysis rate and rate of [<br>
                            <sup>3</sup><br>
                            H]E<br>
                            <sub>2</sub><br>
                             formation were significantly lower in normal breast tissue than in breast carcinoma and in normal and neoplastic endometrium. The specific ability of normal breast tissue to convert E<br>
                            <sub>1</sub><br>
                            S into the terminal biologically active estrogen E<br>
                            <sub>2</sub><br>
                             may be important for estrogenic stimulation of the breast in subjects with low circulating E<br>
                            <sub>2</sub><br>
                             levels. The lower rate of E<br>
                            <sub>1</sub><br>
                             formation in OC users may reflect an inhibitory effect of the progestagen compound in such preparations.</p>},
  author       = {Söderqvist, Gunnar and Olsson, Håkan and Wilking, Nils and von Schoultz, Bo and Carlström, Kjell},
  issn         = {0960-0760},
  language     = {eng},
  month        = {01},
  number       = {2-3},
  pages        = {221--224},
  publisher    = {Elsevier},
  series       = {Journal of Steroid Biochemistry and Molecular Biology},
  title        = {Metabolism of estrone sulfate by normal breast tissue : Influence of menopausal status and oral contraceptives},
  url          = {http://dx.doi.org/10.1016/0960-0760(94)90148-1},
  volume       = {48},
  year         = {1994},
}