Short-term effect of induced alterations in testosterone levels on fasting plasma amino acid levels in healthy young men
(2021) In Life 11(11).- Abstract
Long term effect of testosterone (T) deficiency impairs metabolism and is associated with muscle degradation and metabolic disease. The association seems to have a bidirectional nature and is not well understood. The present study aims to investigate the early and unidirectional metabolic effect of induced T changes by measuring fasting amino acid (AA) levels in a human model, in which short-term T alterations were induced. We designed a human model of 30 healthy young males with pharmacologically induced T changes, which resulted in three time points for blood collection: (A) baseline, (B) low T (3 weeks post administration of gonadotropin releasing hormone antagonist) and (C) restored T (2 weeks after injection of T undecanoate). The... (More)
Long term effect of testosterone (T) deficiency impairs metabolism and is associated with muscle degradation and metabolic disease. The association seems to have a bidirectional nature and is not well understood. The present study aims to investigate the early and unidirectional metabolic effect of induced T changes by measuring fasting amino acid (AA) levels in a human model, in which short-term T alterations were induced. We designed a human model of 30 healthy young males with pharmacologically induced T changes, which resulted in three time points for blood collection: (A) baseline, (B) low T (3 weeks post administration of gonadotropin releasing hormone antagonist) and (C) restored T (2 weeks after injection of T undecanoate). The influence of T on AAs was analyzed by spectrophotometry on plasma samples. Levels of 9 out of 23 AAs, of which 7 were essential AAs, were significantly increased at low T and are restored upon T supplementation. Levels of tyrosine and phenylalanine were most strongly associated to T changes. Short-term effect of T changes suggests an increased protein breakdown that is restored upon T supplementation. Fasting AA levels are able to monitor the early metabolic changes induced by the T fluctuations.
(Less)
- author
- organization
- publishing date
- 2021-11
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Gluconeogenesis, Protein breakdown, Testosterone
- in
- Life
- volume
- 11
- issue
- 11
- article number
- 1276
- publisher
- MDPI AG
- external identifiers
-
- scopus:85120061392
- pmid:34833152
- ISSN
- 0024-3019
- DOI
- 10.3390/life11111276
- language
- English
- LU publication?
- yes
- id
- b5821bed-86d8-4412-9fc2-c99f36ede390
- date added to LUP
- 2021-12-15 12:32:50
- date last changed
- 2025-01-13 20:02:07
@article{b5821bed-86d8-4412-9fc2-c99f36ede390, abstract = {{<p>Long term effect of testosterone (T) deficiency impairs metabolism and is associated with muscle degradation and metabolic disease. The association seems to have a bidirectional nature and is not well understood. The present study aims to investigate the early and unidirectional metabolic effect of induced T changes by measuring fasting amino acid (AA) levels in a human model, in which short-term T alterations were induced. We designed a human model of 30 healthy young males with pharmacologically induced T changes, which resulted in three time points for blood collection: (A) baseline, (B) low T (3 weeks post administration of gonadotropin releasing hormone antagonist) and (C) restored T (2 weeks after injection of T undecanoate). The influence of T on AAs was analyzed by spectrophotometry on plasma samples. Levels of 9 out of 23 AAs, of which 7 were essential AAs, were significantly increased at low T and are restored upon T supplementation. Levels of tyrosine and phenylalanine were most strongly associated to T changes. Short-term effect of T changes suggests an increased protein breakdown that is restored upon T supplementation. Fasting AA levels are able to monitor the early metabolic changes induced by the T fluctuations.</p>}}, author = {{Barbara Sahlin, K. and Pla, Indira and de Siqueira Guedes, Jéssica and Pawłowski, Krzysztof and Appelqvist, Roger and Marko-Varga, György and Domont, Gilberto Barbosa and Nogueira, Fábio César Sousa and Giwercman, Aleksander and Sanchez, Aniel and Malm, Johan}}, issn = {{0024-3019}}, keywords = {{Gluconeogenesis; Protein breakdown; Testosterone}}, language = {{eng}}, number = {{11}}, publisher = {{MDPI AG}}, series = {{Life}}, title = {{Short-term effect of induced alterations in testosterone levels on fasting plasma amino acid levels in healthy young men}}, url = {{http://dx.doi.org/10.3390/life11111276}}, doi = {{10.3390/life11111276}}, volume = {{11}}, year = {{2021}}, }