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Short-term effect of induced alterations in testosterone levels on fasting plasma amino acid levels in healthy young men

Barbara Sahlin, K. ; Pla, Indira LU orcid ; de Siqueira Guedes, Jéssica ; Pawłowski, Krzysztof LU ; Appelqvist, Roger LU ; Marko-Varga, György LU ; Domont, Gilberto Barbosa ; Nogueira, Fábio César Sousa LU ; Giwercman, Aleksander LU and Sanchez, Aniel LU , et al. (2021) In Life 11(11).
Abstract

Long term effect of testosterone (T) deficiency impairs metabolism and is associated with muscle degradation and metabolic disease. The association seems to have a bidirectional nature and is not well understood. The present study aims to investigate the early and unidirectional metabolic effect of induced T changes by measuring fasting amino acid (AA) levels in a human model, in which short-term T alterations were induced. We designed a human model of 30 healthy young males with pharmacologically induced T changes, which resulted in three time points for blood collection: (A) baseline, (B) low T (3 weeks post administration of gonadotropin releasing hormone antagonist) and (C) restored T (2 weeks after injection of T undecanoate). The... (More)

Long term effect of testosterone (T) deficiency impairs metabolism and is associated with muscle degradation and metabolic disease. The association seems to have a bidirectional nature and is not well understood. The present study aims to investigate the early and unidirectional metabolic effect of induced T changes by measuring fasting amino acid (AA) levels in a human model, in which short-term T alterations were induced. We designed a human model of 30 healthy young males with pharmacologically induced T changes, which resulted in three time points for blood collection: (A) baseline, (B) low T (3 weeks post administration of gonadotropin releasing hormone antagonist) and (C) restored T (2 weeks after injection of T undecanoate). The influence of T on AAs was analyzed by spectrophotometry on plasma samples. Levels of 9 out of 23 AAs, of which 7 were essential AAs, were significantly increased at low T and are restored upon T supplementation. Levels of tyrosine and phenylalanine were most strongly associated to T changes. Short-term effect of T changes suggests an increased protein breakdown that is restored upon T supplementation. Fasting AA levels are able to monitor the early metabolic changes induced by the T fluctuations.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Gluconeogenesis, Protein breakdown, Testosterone
in
Life
volume
11
issue
11
article number
1276
publisher
MDPI AG
external identifiers
  • scopus:85120061392
  • pmid:34833152
ISSN
0024-3019
DOI
10.3390/life11111276
language
English
LU publication?
yes
id
b5821bed-86d8-4412-9fc2-c99f36ede390
date added to LUP
2021-12-15 12:32:50
date last changed
2024-06-15 22:46:16
@article{b5821bed-86d8-4412-9fc2-c99f36ede390,
  abstract     = {{<p>Long term effect of testosterone (T) deficiency impairs metabolism and is associated with muscle degradation and metabolic disease. The association seems to have a bidirectional nature and is not well understood. The present study aims to investigate the early and unidirectional metabolic effect of induced T changes by measuring fasting amino acid (AA) levels in a human model, in which short-term T alterations were induced. We designed a human model of 30 healthy young males with pharmacologically induced T changes, which resulted in three time points for blood collection: (A) baseline, (B) low T (3 weeks post administration of gonadotropin releasing hormone antagonist) and (C) restored T (2 weeks after injection of T undecanoate). The influence of T on AAs was analyzed by spectrophotometry on plasma samples. Levels of 9 out of 23 AAs, of which 7 were essential AAs, were significantly increased at low T and are restored upon T supplementation. Levels of tyrosine and phenylalanine were most strongly associated to T changes. Short-term effect of T changes suggests an increased protein breakdown that is restored upon T supplementation. Fasting AA levels are able to monitor the early metabolic changes induced by the T fluctuations.</p>}},
  author       = {{Barbara Sahlin, K. and Pla, Indira and de Siqueira Guedes, Jéssica and Pawłowski, Krzysztof and Appelqvist, Roger and Marko-Varga, György and Domont, Gilberto Barbosa and Nogueira, Fábio César Sousa and Giwercman, Aleksander and Sanchez, Aniel and Malm, Johan}},
  issn         = {{0024-3019}},
  keywords     = {{Gluconeogenesis; Protein breakdown; Testosterone}},
  language     = {{eng}},
  number       = {{11}},
  publisher    = {{MDPI AG}},
  series       = {{Life}},
  title        = {{Short-term effect of induced alterations in testosterone levels on fasting plasma amino acid levels in healthy young men}},
  url          = {{http://dx.doi.org/10.3390/life11111276}},
  doi          = {{10.3390/life11111276}},
  volume       = {{11}},
  year         = {{2021}},
}