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Validation of a European Cross-Cultural Neuropsychological Test Battery (CNTB) for evaluation of dementia

Nielsen, T. Rune; Segers, Kurt; Vanderaspoilden, Valérie; Beinhoff, Ulrike; Minthon, Lennart LU ; Pissiota, Anna; Bekkhus-Wetterberg, Peter; Bjørkløf, Guro Hanevold; Tsolaki, Magda and Gkioka, Mara, et al. (2019) In International Journal of Geriatric Psychiatry 34(1). p.144-152
Abstract

Background: The aims of this study were to establish the diagnostic accuracy of the European Cross-Cultural Neuropsychological Test Battery (CNTB) for dementia in different ethnic populations in Western Europe, to examine its ability to differentiate cognitive impairment profiles for dementia subtypes, and to assess the impact of demographic variables on diagnostic properties. Methods: The study was a Western European cross-sectional multi-center study. A total of 66 patients with dementia and 118 cognitively intact participants were included across six memory clinics; 93 had ethnic minority background and 91 had ethnic majority background. Tests in the CNTB cover global cognitive function, memory, language, executive functions, and... (More)

Background: The aims of this study were to establish the diagnostic accuracy of the European Cross-Cultural Neuropsychological Test Battery (CNTB) for dementia in different ethnic populations in Western Europe, to examine its ability to differentiate cognitive impairment profiles for dementia subtypes, and to assess the impact of demographic variables on diagnostic properties. Methods: The study was a Western European cross-sectional multi-center study. A total of 66 patients with dementia and 118 cognitively intact participants were included across six memory clinics; 93 had ethnic minority background and 91 had ethnic majority background. Tests in the CNTB cover global cognitive function, memory, language, executive functions, and visuospatial functions. Results: Significant differences with moderate to large effect sizes were present between patients with dementia and control participants on all CNTB measures. Area under the curves (AUC) ranged from.62 to.99 with a mean AUC across all measures of.83. Comparison of ethnic minority and majority groups generally revealed higher sensitivity in the minority group but no significant difference in the mean AUC's across all measures (.84 vs78, P =.42). Comparison of impairment profiles for patients with Alzheimer's disease (AD) and non-AD dementia revealed that AD patients were significantly more impaired on the memory domain, whereas patients with non-AD dementia were more impaired on the executive functions domain. Conclusions: The CNTB was found to have promising cross-cultural diagnostic properties for evaluation of dementia in the targeted minority and majority populations and could represent a valid cross-cultural alternative to other well-established neuropsychological test batteries when assessing patients from these populations.

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subject
keywords
Alzheimer's disease, cognitive assessment, dementia, diagnostic accuracy, ethnic groups, neuropsychological tests
in
International Journal of Geriatric Psychiatry
volume
34
issue
1
pages
144 - 152
publisher
John Wiley and Sons Ltd
external identifiers
  • scopus:85055193282
ISSN
0885-6230
DOI
10.1002/gps.5002
language
English
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yes
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b6bd8b0d-1122-4b79-9dd7-f08391b15dc6
date added to LUP
2018-12-17 15:23:13
date last changed
2019-10-15 06:52:41
@article{b6bd8b0d-1122-4b79-9dd7-f08391b15dc6,
  abstract     = {<p>Background: The aims of this study were to establish the diagnostic accuracy of the European Cross-Cultural Neuropsychological Test Battery (CNTB) for dementia in different ethnic populations in Western Europe, to examine its ability to differentiate cognitive impairment profiles for dementia subtypes, and to assess the impact of demographic variables on diagnostic properties. Methods: The study was a Western European cross-sectional multi-center study. A total of 66 patients with dementia and 118 cognitively intact participants were included across six memory clinics; 93 had ethnic minority background and 91 had ethnic majority background. Tests in the CNTB cover global cognitive function, memory, language, executive functions, and visuospatial functions. Results: Significant differences with moderate to large effect sizes were present between patients with dementia and control participants on all CNTB measures. Area under the curves (AUC) ranged from.62 to.99 with a mean AUC across all measures of.83. Comparison of ethnic minority and majority groups generally revealed higher sensitivity in the minority group but no significant difference in the mean AUC's across all measures (.84 vs78, P =.42). Comparison of impairment profiles for patients with Alzheimer's disease (AD) and non-AD dementia revealed that AD patients were significantly more impaired on the memory domain, whereas patients with non-AD dementia were more impaired on the executive functions domain. Conclusions: The CNTB was found to have promising cross-cultural diagnostic properties for evaluation of dementia in the targeted minority and majority populations and could represent a valid cross-cultural alternative to other well-established neuropsychological test batteries when assessing patients from these populations.</p>},
  author       = {Nielsen, T. Rune and Segers, Kurt and Vanderaspoilden, Valérie and Beinhoff, Ulrike and Minthon, Lennart and Pissiota, Anna and Bekkhus-Wetterberg, Peter and Bjørkløf, Guro Hanevold and Tsolaki, Magda and Gkioka, Mara and Waldemar, Gunhild},
  issn         = {0885-6230},
  keyword      = {Alzheimer's disease,cognitive assessment,dementia,diagnostic accuracy,ethnic groups,neuropsychological tests},
  language     = {eng},
  number       = {1},
  pages        = {144--152},
  publisher    = {John Wiley and Sons Ltd},
  series       = {International Journal of Geriatric Psychiatry},
  title        = {Validation of a European Cross-Cultural Neuropsychological Test Battery (CNTB) for evaluation of dementia},
  url          = {http://dx.doi.org/10.1002/gps.5002},
  volume       = {34},
  year         = {2019},
}