High-resolution neutron spectroscopy on protein solution samples
(2015) 11th International Conference on Quasielastic Neutron Scattering, QENS 2014 and 6th International Workshop on Inelastic Neutron Spectrometers, WINS 2014 In EPJ Web of Conferences 83.- Abstract
Proteins in solution move subject to a complex superposition of global translational and rotational diffusion as well as internal relaxations covering a wide range of time scales. With the advent of new high-flux neutron spectrometers in combination with enhanced analysis frameworks it has become possible to separate these different contributions. We discuss new approaches to the analysis by presenting example spectra and fits from data recorded on the backscattering spectrometers IN16, IN16B, and BASIS on the same protein solution sample. We illustrate the separation of the rotational and translational diffusion contribution, the accurate treatment of the solvent contribution, and the extraction of information on internal fluctuations.... (More)
Proteins in solution move subject to a complex superposition of global translational and rotational diffusion as well as internal relaxations covering a wide range of time scales. With the advent of new high-flux neutron spectrometers in combination with enhanced analysis frameworks it has become possible to separate these different contributions. We discuss new approaches to the analysis by presenting example spectra and fits from data recorded on the backscattering spectrometers IN16, IN16B, and BASIS on the same protein solution sample. We illustrate the separation of the rotational and translational diffusion contribution, the accurate treatment of the solvent contribution, and the extraction of information on internal fluctuations. We also exemplify the progress made in passing from second- to third-generation backscattering spectrometers.
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- author
- Grimaldo, Marco ; Roosen-Runge, Felix LU ; Jalarvo, Niina ; Zamponi, Michaela ; Zanini, Fabio ; Hennig, Marcus ; Zhang, Fajun ; Schreiber, Frank and Seydel, Tilo
- publishing date
- 2015
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- host publication
- 11th International Conference on Quasielastic Neutron Scattering, QENS 2014 and 6th International Workshop on Inelastic Neutron Spectrometers, WINS 2014
- series title
- EPJ Web of Conferences
- volume
- 83
- article number
- 02005
- conference name
- 11th International Conference on Quasielastic Neutron Scattering, QENS 2014 and 6th International Workshop on Inelastic Neutron Spectrometers, WINS 2014
- conference location
- Autrans, France
- conference dates
- 2014-05-11 - 2014-05-16
- external identifiers
-
- scopus:84921820321
- ISSN
- 2101-6275
- DOI
- 10.1051/epjconf/20158302005
- language
- English
- LU publication?
- no
- id
- b70f23c4-6f25-40c1-bc2a-f563ac353f92
- date added to LUP
- 2018-12-17 09:44:40
- date last changed
- 2022-01-31 20:38:04
@inproceedings{b70f23c4-6f25-40c1-bc2a-f563ac353f92, abstract = {{<p>Proteins in solution move subject to a complex superposition of global translational and rotational diffusion as well as internal relaxations covering a wide range of time scales. With the advent of new high-flux neutron spectrometers in combination with enhanced analysis frameworks it has become possible to separate these different contributions. We discuss new approaches to the analysis by presenting example spectra and fits from data recorded on the backscattering spectrometers IN16, IN16B, and BASIS on the same protein solution sample. We illustrate the separation of the rotational and translational diffusion contribution, the accurate treatment of the solvent contribution, and the extraction of information on internal fluctuations. We also exemplify the progress made in passing from second- to third-generation backscattering spectrometers.</p>}}, author = {{Grimaldo, Marco and Roosen-Runge, Felix and Jalarvo, Niina and Zamponi, Michaela and Zanini, Fabio and Hennig, Marcus and Zhang, Fajun and Schreiber, Frank and Seydel, Tilo}}, booktitle = {{11th International Conference on Quasielastic Neutron Scattering, QENS 2014 and 6th International Workshop on Inelastic Neutron Spectrometers, WINS 2014}}, issn = {{2101-6275}}, language = {{eng}}, series = {{EPJ Web of Conferences}}, title = {{High-resolution neutron spectroscopy on protein solution samples}}, url = {{http://dx.doi.org/10.1051/epjconf/20158302005}}, doi = {{10.1051/epjconf/20158302005}}, volume = {{83}}, year = {{2015}}, }