A focused very high energy electron beam for fractionated stereotactic radiotherapy
(2021) In Scientific Reports 11(1).- Abstract
An electron beam of very high energy (50–250 MeV) can potentially produce a more favourable radiotherapy dose distribution compared to a state-of-the-art photon based radiotherapy technique. To produce an electron beam of sufficiently high energy to allow for a long penetration depth (several cm), very large accelerating structures are needed when using conventional radio-frequency technology, which may not be possible due to economical or spatial constraints. In this paper, we show transport and focusing of laser wakefield accelerated electron beams with a maximum energy of 160 MeV using electromagnetic quadrupole magnets in a point-to-point imaging configuration, yielding a spatial uncertainty of less than 0.1 mm, a total charge... (More)
An electron beam of very high energy (50–250 MeV) can potentially produce a more favourable radiotherapy dose distribution compared to a state-of-the-art photon based radiotherapy technique. To produce an electron beam of sufficiently high energy to allow for a long penetration depth (several cm), very large accelerating structures are needed when using conventional radio-frequency technology, which may not be possible due to economical or spatial constraints. In this paper, we show transport and focusing of laser wakefield accelerated electron beams with a maximum energy of 160 MeV using electromagnetic quadrupole magnets in a point-to-point imaging configuration, yielding a spatial uncertainty of less than 0.1 mm, a total charge variation below 1 % and a focal spot of 2.3×2.6mm2. The electron beam was focused to control the depth dose distribution and to improve the dose conformality inside a phantom of cast acrylic slabs and radiochromic film. The phantom was irradiated from 36 different angles to obtain a dose distribution mimicking a stereotactic radiotherapy treatment, with a peak fractional dose of 2.72 Gy and a total maximum dose of 65 Gy. This was achieved with realistic constraints, including 23 cm of propagation through air before any dose deposition in the phantom.
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- author
- Svendsen, Kristoffer LU ; Guénot, Diego LU ; Svensson, Jonas Björklund LU ; Petersson, Kristoffer LU ; Persson, Anders LU and Lundh, Olle LU
- organization
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Scientific Reports
- volume
- 11
- issue
- 1
- article number
- 5844
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:33712653
- scopus:85102503538
- ISSN
- 2045-2322
- DOI
- 10.1038/s41598-021-85451-8
- language
- English
- LU publication?
- yes
- id
- b75d4bda-084e-4489-bb93-198018a84ebf
- date added to LUP
- 2021-03-23 08:00:56
- date last changed
- 2024-04-18 04:44:16
@article{b75d4bda-084e-4489-bb93-198018a84ebf,
abstract = {{<p>An electron beam of very high energy (50–250 MeV) can potentially produce a more favourable radiotherapy dose distribution compared to a state-of-the-art photon based radiotherapy technique. To produce an electron beam of sufficiently high energy to allow for a long penetration depth (several cm), very large accelerating structures are needed when using conventional radio-frequency technology, which may not be possible due to economical or spatial constraints. In this paper, we show transport and focusing of laser wakefield accelerated electron beams with a maximum energy of 160 MeV using electromagnetic quadrupole magnets in a point-to-point imaging configuration, yielding a spatial uncertainty of less than 0.1 mm, a total charge variation below 1 % and a focal spot of 2.3×2.6mm2. The electron beam was focused to control the depth dose distribution and to improve the dose conformality inside a phantom of cast acrylic slabs and radiochromic film. The phantom was irradiated from 36 different angles to obtain a dose distribution mimicking a stereotactic radiotherapy treatment, with a peak fractional dose of 2.72 Gy and a total maximum dose of 65 Gy. This was achieved with realistic constraints, including 23 cm of propagation through air before any dose deposition in the phantom.</p>}},
author = {{Svendsen, Kristoffer and Guénot, Diego and Svensson, Jonas Björklund and Petersson, Kristoffer and Persson, Anders and Lundh, Olle}},
issn = {{2045-2322}},
language = {{eng}},
number = {{1}},
publisher = {{Nature Publishing Group}},
series = {{Scientific Reports}},
title = {{A focused very high energy electron beam for fractionated stereotactic radiotherapy}},
url = {{http://dx.doi.org/10.1038/s41598-021-85451-8}},
doi = {{10.1038/s41598-021-85451-8}},
volume = {{11}},
year = {{2021}},
}