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Molecular recognition polymer microspheres and nanoparticles for nonseparation assays: the Mosbach imprint

Ye, Lei LU orcid ; Zhang, Tong LU and Zhang, Qicheng LU (2025) In TrAC - Trends in Analytical Chemistry 191.
Abstract
Synthesis of molecularly imprinted polymer microspheres using precipitation polymerization was first reported in 1999 in Lund. The synthetic approach attracted great interest for molecular imprinters worldwide due to its simplicity. Following the initial demonstration of feasibility for material synthesis, imprinted polymer microspheres were found to exhibit good colloidal stability qualifying for use as antibody substitutes in a proximity scintillation assay. In the following years, other types of nonseparation assays using imprinted polymer microspheres started to be developed. Molecular detection based on fluorescence measurements eventually became the method of choice to avoid radioactive tracers. Many of the research ideas have been... (More)
Synthesis of molecularly imprinted polymer microspheres using precipitation polymerization was first reported in 1999 in Lund. The synthetic approach attracted great interest for molecular imprinters worldwide due to its simplicity. Following the initial demonstration of feasibility for material synthesis, imprinted polymer microspheres were found to exhibit good colloidal stability qualifying for use as antibody substitutes in a proximity scintillation assay. In the following years, other types of nonseparation assays using imprinted polymer microspheres started to be developed. Molecular detection based on fluorescence measurements eventually became the method of choice to avoid radioactive tracers. Many of the research ideas have been inspired by the earlier contributions from Professor Klaus Mosbach. This manuscript provides a historic review on molecularly imprinted polymer microspheres and nanoparticles designed for nonseparation assays. While the main thread is the research evolvement of the authors’ laboratory till the present time, important contributions from other groups are also discussed. (Less)
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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
TrAC - Trends in Analytical Chemistry
volume
191
article number
118370
pages
10 pages
publisher
Elsevier
external identifiers
  • scopus:105010332580
ISSN
0165-9936
DOI
10.1016/j.trac.2025.118370
language
English
LU publication?
yes
id
b777a6d9-6301-425e-95e4-20ae034483b4
date added to LUP
2025-08-15 04:23:07
date last changed
2025-08-18 08:46:42
@article{b777a6d9-6301-425e-95e4-20ae034483b4,
  abstract     = {{Synthesis of molecularly imprinted polymer microspheres using precipitation polymerization was first reported in 1999 in Lund. The synthetic approach attracted great interest for molecular imprinters worldwide due to its simplicity. Following the initial demonstration of feasibility for material synthesis, imprinted polymer microspheres were found to exhibit good colloidal stability qualifying for use as antibody substitutes in a proximity scintillation assay. In the following years, other types of nonseparation assays using imprinted polymer microspheres started to be developed. Molecular detection based on fluorescence measurements eventually became the method of choice to avoid radioactive tracers. Many of the research ideas have been inspired by the earlier contributions from Professor Klaus Mosbach. This manuscript provides a historic review on molecularly imprinted polymer microspheres and nanoparticles designed for nonseparation assays. While the main thread is the research evolvement of the authors’ laboratory till the present time, important contributions from other groups are also discussed.}},
  author       = {{Ye, Lei and Zhang, Tong and Zhang, Qicheng}},
  issn         = {{0165-9936}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{TrAC - Trends in Analytical Chemistry}},
  title        = {{Molecular recognition polymer microspheres and nanoparticles for nonseparation assays: the Mosbach imprint}},
  url          = {{http://dx.doi.org/10.1016/j.trac.2025.118370}},
  doi          = {{10.1016/j.trac.2025.118370}},
  volume       = {{191}},
  year         = {{2025}},
}