Cubosomes and hexosomes stabilized by sorbitan monooleate as biocompatible nanoplatforms against skin metastatic human melanoma
Fornasier, Marco LU
; Krautforst, Karolina
LU
; Kulbacka, Julita
; Jönsson, Peter
LU
; Murgia, Sergio
and Bazylińska, Urszula
(2025)
In Journal of Colloid and Interface Science
677.
p.842-852
- Abstract
Nanoparticles have become versatile assets in the medical field, providing notable benefits across diverse medical arenas including controlled drug delivery, imaging, and immunological assays. Among these, non-lamellar lipid nanoparticles, notably cubosomes and hexosomes, showcase remarkable biocompatibility and stability, rendering them as optimal choices for theranostic applications. Particularly, incorporating edge activators like sodium taurocholate enhances the potential of these nanoparticles for dermal and transdermal drug delivery, overcoming the stratum corneum, a first line of defense in our skin. This study reports on the formulation of monoolein-based cubosomes and hexosomes incorporating taurocholate and stabilized by Span... (More)
Nanoparticles have become versatile assets in the medical field, providing notable benefits across diverse medical arenas including controlled drug delivery, imaging, and immunological assays. Among these, non-lamellar lipid nanoparticles, notably cubosomes and hexosomes, showcase remarkable biocompatibility and stability, rendering them as optimal choices for theranostic applications. Particularly, incorporating edge activators like sodium taurocholate enhances the potential of these nanoparticles for dermal and transdermal drug delivery, overcoming the stratum corneum, a first line of defense in our skin. This study reports on the formulation of monoolein-based cubosomes and hexosomes incorporating taurocholate and stabilized by Span 80 and co-encapsulating Chlorin e6 and coenzyme QH for photodynamic therapy in skin metastatic melanoma. The formulations were optimized using small-angle X-ray scattering, and cryo-transmission electron microscopy confirmed the presence of cubosomes or hexosomes, depending on the ratio between taurocholate and Span 80. Furthermore, the co-loaded nanoparticles exhibited high encapsulation efficiencies for both Ce6 and the coenzyme QH. In vitro studies on human melanoma cells (Me45) demonstrated the biocompatibility and photodynamic activity of the loaded formulations. These findings show the possibility of formulating more biocompatible cubosomes and hexosomes for photodynamic therapy in skin cancer treatment.
(Less)
- author
- Fornasier, Marco
LU
; Krautforst, Karolina
LU
; Kulbacka, Julita
; Jönsson, Peter
LU
; Murgia, Sergio
and Bazylińska, Urszula
- organization
- publishing date
- 2025-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Bile salts, Cubosomes, Cytotoxicity, Edge activators, Hexosomes, Non-lamellar, Photodynamic therapy, Stabilizer
- in
- Journal of Colloid and Interface Science
- volume
- 677
- pages
- 11 pages
- publisher
- Academic Press
- external identifiers
-
- pmid:39173516
- scopus:85201625555
- ISSN
- 0021-9797
- DOI
- 10.1016/j.jcis.2024.08.126
- language
- English
- LU publication?
- yes
- id
- b78105a8-8606-4de8-8be4-7b83ac5ffce5
- date added to LUP
- 2024-10-30 13:20:26
- date last changed
- 2025-07-10 11:51:33
@article{b78105a8-8606-4de8-8be4-7b83ac5ffce5,
abstract = {{<p>Nanoparticles have become versatile assets in the medical field, providing notable benefits across diverse medical arenas including controlled drug delivery, imaging, and immunological assays. Among these, non-lamellar lipid nanoparticles, notably cubosomes and hexosomes, showcase remarkable biocompatibility and stability, rendering them as optimal choices for theranostic applications. Particularly, incorporating edge activators like sodium taurocholate enhances the potential of these nanoparticles for dermal and transdermal drug delivery, overcoming the stratum corneum, a first line of defense in our skin. This study reports on the formulation of monoolein-based cubosomes and hexosomes incorporating taurocholate and stabilized by Span 80 and co-encapsulating Chlorin e6 and coenzyme QH for photodynamic therapy in skin metastatic melanoma. The formulations were optimized using small-angle X-ray scattering, and cryo-transmission electron microscopy confirmed the presence of cubosomes or hexosomes, depending on the ratio between taurocholate and Span 80. Furthermore, the co-loaded nanoparticles exhibited high encapsulation efficiencies for both Ce6 and the coenzyme QH. In vitro studies on human melanoma cells (Me45) demonstrated the biocompatibility and photodynamic activity of the loaded formulations. These findings show the possibility of formulating more biocompatible cubosomes and hexosomes for photodynamic therapy in skin cancer treatment.</p>}},
author = {{Fornasier, Marco and Krautforst, Karolina and Kulbacka, Julita and Jönsson, Peter and Murgia, Sergio and Bazylińska, Urszula}},
issn = {{0021-9797}},
keywords = {{Bile salts; Cubosomes; Cytotoxicity; Edge activators; Hexosomes; Non-lamellar; Photodynamic therapy; Stabilizer}},
language = {{eng}},
pages = {{842--852}},
publisher = {{Academic Press}},
series = {{Journal of Colloid and Interface Science}},
title = {{Cubosomes and hexosomes stabilized by sorbitan monooleate as biocompatible nanoplatforms against skin metastatic human melanoma}},
url = {{http://dx.doi.org/10.1016/j.jcis.2024.08.126}},
doi = {{10.1016/j.jcis.2024.08.126}},
volume = {{677}},
year = {{2025}},
}