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A nationwide family study of venous thromboembolism and risk of arterial vascular disease

Zöller, Bengt LU ; Li, Xinjun LU ; Sundquist, Jan LU and Sundquist, Kristina LU (2016) In Heart 102(16). p.1315-1321
Abstract

OBJECTIVE: This nationwide study aimed to determine whether venous thromboembolism (VTE) shares familial susceptibility with aortic aneurysm (AA), peripheral artery disease (PAD) and arterial thrombosis and embolisation (ATE) in locations other than the heart and brain.

METHODS: Nationwide Swedish family study. Data from the Swedish Multi-Generation Register for subjects aged 0-78 years old, covering the period 1964-2010, were linked to the Hospital Register. Familial risks (standardised incidence ratio, SIR) of AA, PAD and ATE were determined for individuals with a first-degree relative (parents/sibling) diagnosed with VTE. Separate analyses were done to determine risks for spouses.

RESULTS: A total of 13 063 individuals... (More)

OBJECTIVE: This nationwide study aimed to determine whether venous thromboembolism (VTE) shares familial susceptibility with aortic aneurysm (AA), peripheral artery disease (PAD) and arterial thrombosis and embolisation (ATE) in locations other than the heart and brain.

METHODS: Nationwide Swedish family study. Data from the Swedish Multi-Generation Register for subjects aged 0-78 years old, covering the period 1964-2010, were linked to the Hospital Register. Familial risks (standardised incidence ratio, SIR) of AA, PAD and ATE were determined for individuals with a first-degree relative (parents/sibling) diagnosed with VTE. Separate analyses were done to determine risks for spouses.

RESULTS: A total of 13 063 individuals had AA, 15 494 had PAD and 7325 had ATE. Fully adjusted familial risks for individuals with family history (parent/sibling) of VTE were 1.04 (95% CI 1.00 to 1.08)) for AA, 1.42 (1.35 to 1.49) for ATE and 1.08 (1.04 to 1.13) for PAD. The familial sibling risks were 1.07 (0.99 to 1.14) for AA, 1.61 (1.48 to 1.74) for ATE and 1.19 (1.11 to 1.26) for PAD. Among individuals younger than 50 years of age, the familial risks were: 1.13 (0.99 to 1.29) for AA, 1.76 (1.62 to 1.91) for ATE and 1.12 (1.03 to 1.21) for PAD. In spouses of patients with VTE, the SIRs were 1.21 (1.17 to 1.25) for AA, 1.19 (1.14 to 1.23) for ATE and 1.26 (1.21 to 1.30) for PAD.

CONCLUSIONS: VTE shares only weak familial susceptibility with AA and PAD in the Swedish population. However, ATE partially shares a moderate familial susceptibility and possibly genetic factors with VTE. Moreover, familial non-genetic factors may contribute to the observed familial associations.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Heart
volume
102
issue
16
pages
1315 - 1321
publisher
BMJ Publishing Group
external identifiers
  • Scopus:84963946903
  • WOS:000382581300014
ISSN
1355-6037
DOI
10.1136/heartjnl-2015-308892
language
English
LU publication?
yes
id
b7ba1ddc-4d46-4819-8962-7cf66864d4f0
date added to LUP
2016-04-28 13:36:11
date last changed
2017-01-10 15:15:16
@article{b7ba1ddc-4d46-4819-8962-7cf66864d4f0,
  abstract     = {<p>OBJECTIVE: This nationwide study aimed to determine whether venous thromboembolism (VTE) shares familial susceptibility with aortic aneurysm (AA), peripheral artery disease (PAD) and arterial thrombosis and embolisation (ATE) in locations other than the heart and brain.</p><p>METHODS: Nationwide Swedish family study. Data from the Swedish Multi-Generation Register for subjects aged 0-78 years old, covering the period 1964-2010, were linked to the Hospital Register. Familial risks (standardised incidence ratio, SIR) of AA, PAD and ATE were determined for individuals with a first-degree relative (parents/sibling) diagnosed with VTE. Separate analyses were done to determine risks for spouses.</p><p>RESULTS: A total of 13 063 individuals had AA, 15 494 had PAD and 7325 had ATE. Fully adjusted familial risks for individuals with family history (parent/sibling) of VTE were 1.04 (95% CI 1.00 to 1.08)) for AA, 1.42 (1.35 to 1.49) for ATE and 1.08 (1.04 to 1.13) for PAD. The familial sibling risks were 1.07 (0.99 to 1.14) for AA, 1.61 (1.48 to 1.74) for ATE and 1.19 (1.11 to 1.26) for PAD. Among individuals younger than 50 years of age, the familial risks were: 1.13 (0.99 to 1.29) for AA, 1.76 (1.62 to 1.91) for ATE and 1.12 (1.03 to 1.21) for PAD. In spouses of patients with VTE, the SIRs were 1.21 (1.17 to 1.25) for AA, 1.19 (1.14 to 1.23) for ATE and 1.26 (1.21 to 1.30) for PAD.</p><p>CONCLUSIONS: VTE shares only weak familial susceptibility with AA and PAD in the Swedish population. However, ATE partially shares a moderate familial susceptibility and possibly genetic factors with VTE. Moreover, familial non-genetic factors may contribute to the observed familial associations.</p>},
  author       = {Zöller, Bengt and Li, Xinjun and Sundquist, Jan and Sundquist, Kristina},
  issn         = {1355-6037},
  language     = {eng},
  number       = {16},
  pages        = {1315--1321},
  publisher    = {BMJ Publishing Group},
  series       = {Heart},
  title        = {A nationwide family study of venous thromboembolism and risk of arterial vascular disease},
  url          = {http://dx.doi.org/10.1136/heartjnl-2015-308892},
  volume       = {102},
  year         = {2016},
}