Presence of microorganisms in children with pharyngotonsillitis and healthy controls : a prospective study in primary healthcare
(2021) In Infection 49(4). p.715-724- Abstract
Purpose: Most studies on paediatric pharyngotonsillitis focus on group A streptococci. This study, however, analyses a broad spectrum of bacteria and viruses related to paediatric pharyngotonsillitis and evaluates their associated clinical symptoms and courses. Methods: This observational prospective study in primary healthcare includes 77 children aged < 15 with a sore throat and 34 asymptomatic children, all of whom were sampled from the tonsils with an E-swab® for analysis with culture and PCR for 14 bacteria and 15 viruses. Patients were evaluated clinically, and their symptoms recorded in diaries for 10 days. Participants were followed up for 3 months by reviewing medical records. Results: A pathogen was detected in... (More)
Purpose: Most studies on paediatric pharyngotonsillitis focus on group A streptococci. This study, however, analyses a broad spectrum of bacteria and viruses related to paediatric pharyngotonsillitis and evaluates their associated clinical symptoms and courses. Methods: This observational prospective study in primary healthcare includes 77 children aged < 15 with a sore throat and 34 asymptomatic children, all of whom were sampled from the tonsils with an E-swab® for analysis with culture and PCR for 14 bacteria and 15 viruses. Patients were evaluated clinically, and their symptoms recorded in diaries for 10 days. Participants were followed up for 3 months by reviewing medical records. Results: A pathogen was detected in 86% of patients and in 71% of controls (P = 0.06). Bacteria were found in 69% of patients and 59% of controls (P = 0.3), and viruses in 36% and 26%, respectively (P = 0.3). Group A streptococci was the most common finding, with a prevalence of 49% and 32%, respectively (P = 0.1). Clinical signs were not useful for distinguishing pathogens. None of the controls and 16% of the patients reconsulted for a sore throat within 3 months. Conclusion: Bacteria were more common than viruses in both study groups. The high rate of pathogens in asymptomatic children interferes with diagnoses based on aetiology.
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- author
- Pallon, Jon LU ; Sundqvist, Martin ; Rööst, Mattias LU ; Danielsson, Patrik ; Neumark, Thomas ; Skovbjerg, Susann ; Svedin, Jonas and Hedin, Katarina LU
- organization
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Aetiology, Children, PCR, Pharyngotonsillitis, Primary healthcare, Prospective
- in
- Infection
- volume
- 49
- issue
- 4
- pages
- 715 - 724
- publisher
- Springer
- external identifiers
-
- scopus:85102294873
- pmid:33686635
- ISSN
- 0300-8126
- DOI
- 10.1007/s15010-021-01595-9
- language
- English
- LU publication?
- yes
- id
- b88abf7a-4f4f-406b-bfb5-7d06c9f2ea3f
- date added to LUP
- 2021-03-29 09:51:08
- date last changed
- 2024-09-21 17:52:30
@article{b88abf7a-4f4f-406b-bfb5-7d06c9f2ea3f, abstract = {{<p>Purpose: Most studies on paediatric pharyngotonsillitis focus on group A streptococci. This study, however, analyses a broad spectrum of bacteria and viruses related to paediatric pharyngotonsillitis and evaluates their associated clinical symptoms and courses. Methods: This observational prospective study in primary healthcare includes 77 children aged < 15 with a sore throat and 34 asymptomatic children, all of whom were sampled from the tonsils with an E-swab<sup>®</sup> for analysis with culture and PCR for 14 bacteria and 15 viruses. Patients were evaluated clinically, and their symptoms recorded in diaries for 10 days. Participants were followed up for 3 months by reviewing medical records. Results: A pathogen was detected in 86% of patients and in 71% of controls (P = 0.06). Bacteria were found in 69% of patients and 59% of controls (P = 0.3), and viruses in 36% and 26%, respectively (P = 0.3). Group A streptococci was the most common finding, with a prevalence of 49% and 32%, respectively (P = 0.1). Clinical signs were not useful for distinguishing pathogens. None of the controls and 16% of the patients reconsulted for a sore throat within 3 months. Conclusion: Bacteria were more common than viruses in both study groups. The high rate of pathogens in asymptomatic children interferes with diagnoses based on aetiology.</p>}}, author = {{Pallon, Jon and Sundqvist, Martin and Rööst, Mattias and Danielsson, Patrik and Neumark, Thomas and Skovbjerg, Susann and Svedin, Jonas and Hedin, Katarina}}, issn = {{0300-8126}}, keywords = {{Aetiology; Children; PCR; Pharyngotonsillitis; Primary healthcare; Prospective}}, language = {{eng}}, number = {{4}}, pages = {{715--724}}, publisher = {{Springer}}, series = {{Infection}}, title = {{Presence of microorganisms in children with pharyngotonsillitis and healthy controls : a prospective study in primary healthcare}}, url = {{http://dx.doi.org/10.1007/s15010-021-01595-9}}, doi = {{10.1007/s15010-021-01595-9}}, volume = {{49}}, year = {{2021}}, }