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The Structure and Classification of Botulinum Toxins

Dong, Min and Stenmark, Pål LU (2019) In Handbook of experimental pharmacology p.1-23
Abstract

Botulinum neurotoxins (BoNTs) are a family of bacterial protein toxins produced by various Clostridium species. They are traditionally classified into seven major serotypes (BoNT/A-G). Recent progress in sequencing microbial genomes has led to an ever-growing number of subtypes, chimeric toxins, BoNT-like toxins, and remotely related BoNT homologs, constituting an expanding BoNT superfamily. Recent structural studies of BoNTs, BoNT progenitor toxin complexes, tetanus neurotoxin (TeNT), toxin-receptor complexes, and toxin-substrate complexes have provided mechanistic understandings of toxin functions and the molecular basis for their variations. The growing BoNT superfamily of toxins present a natural repertoire that can be explored to... (More)

Botulinum neurotoxins (BoNTs) are a family of bacterial protein toxins produced by various Clostridium species. They are traditionally classified into seven major serotypes (BoNT/A-G). Recent progress in sequencing microbial genomes has led to an ever-growing number of subtypes, chimeric toxins, BoNT-like toxins, and remotely related BoNT homologs, constituting an expanding BoNT superfamily. Recent structural studies of BoNTs, BoNT progenitor toxin complexes, tetanus neurotoxin (TeNT), toxin-receptor complexes, and toxin-substrate complexes have provided mechanistic understandings of toxin functions and the molecular basis for their variations. The growing BoNT superfamily of toxins present a natural repertoire that can be explored to develop novel therapeutic toxins, and the structural understanding of their variations provides a knowledge basis for engineering toxins to improve therapeutic efficacy and expand their clinical applications.

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author
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organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
epub
subject
host publication
Handbook of Experimental Pharmacology
series title
Handbook of experimental pharmacology
pages
1 - 23
publisher
Springer Nature Switzerland AG
external identifiers
  • pmid:31792680
ISSN
0171-2004
DOI
10.1007/164_2019_342
language
English
LU publication?
yes
id
b894e3fa-222e-40c0-8069-026751647e6d
date added to LUP
2019-12-11 12:46:16
date last changed
2019-12-12 09:47:23
@inbook{b894e3fa-222e-40c0-8069-026751647e6d,
  abstract     = {<p>Botulinum neurotoxins (BoNTs) are a family of bacterial protein toxins produced by various Clostridium species. They are traditionally classified into seven major serotypes (BoNT/A-G). Recent progress in sequencing microbial genomes has led to an ever-growing number of subtypes, chimeric toxins, BoNT-like toxins, and remotely related BoNT homologs, constituting an expanding BoNT superfamily. Recent structural studies of BoNTs, BoNT progenitor toxin complexes, tetanus neurotoxin (TeNT), toxin-receptor complexes, and toxin-substrate complexes have provided mechanistic understandings of toxin functions and the molecular basis for their variations. The growing BoNT superfamily of toxins present a natural repertoire that can be explored to develop novel therapeutic toxins, and the structural understanding of their variations provides a knowledge basis for engineering toxins to improve therapeutic efficacy and expand their clinical applications.</p>},
  author       = {Dong, Min and Stenmark, Pål},
  booktitle    = {Handbook of Experimental Pharmacology},
  issn         = {0171-2004},
  language     = {eng},
  month        = {12},
  pages        = {1--23},
  publisher    = {Springer Nature Switzerland AG},
  series       = {Handbook of experimental pharmacology},
  title        = {The Structure and Classification of Botulinum Toxins},
  url          = {http://dx.doi.org/10.1007/164_2019_342},
  doi          = {10.1007/164_2019_342},
  year         = {2019},
}