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The Structure and Classification of Botulinum Toxins

Dong, Min and Stenmark, Pål LU orcid (2021) In Handbook of experimental pharmacology 263. p.11-33
Abstract

Botulinum neurotoxins (BoNTs) are a family of bacterial protein toxins produced by various Clostridium species. They are traditionally classified into seven major serotypes (BoNT/A-G). Recent progress in sequencing microbial genomes has led to an ever-growing number of subtypes, chimeric toxins, BoNT-like toxins, and remotely related BoNT homologs, constituting an expanding BoNT superfamily. Recent structural studies of BoNTs, BoNT progenitor toxin complexes, tetanus neurotoxin (TeNT), toxin-receptor complexes, and toxin-substrate complexes have provided mechanistic understandings of toxin functions and the molecular basis for their variations. The growing BoNT superfamily of toxins present a natural repertoire that can be explored to... (More)

Botulinum neurotoxins (BoNTs) are a family of bacterial protein toxins produced by various Clostridium species. They are traditionally classified into seven major serotypes (BoNT/A-G). Recent progress in sequencing microbial genomes has led to an ever-growing number of subtypes, chimeric toxins, BoNT-like toxins, and remotely related BoNT homologs, constituting an expanding BoNT superfamily. Recent structural studies of BoNTs, BoNT progenitor toxin complexes, tetanus neurotoxin (TeNT), toxin-receptor complexes, and toxin-substrate complexes have provided mechanistic understandings of toxin functions and the molecular basis for their variations. The growing BoNT superfamily of toxins present a natural repertoire that can be explored to develop novel therapeutic toxins, and the structural understanding of their variations provides a knowledge basis for engineering toxins to improve therapeutic efficacy and expand their clinical applications.

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Please use this url to cite or link to this publication:
author
and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
host publication
Botulinum Toxin Therapy
series title
Handbook of experimental pharmacology
editor
Whitcup, Scott M. and Hallett, Mark
volume
263
pages
23 pages
publisher
Springer Nature
external identifiers
  • scopus:85099428704
  • pmid:31792680
ISSN
0171-2004
ISBN
978-3-030-66305-6
DOI
10.1007/164_2019_342
language
English
LU publication?
yes
id
b894e3fa-222e-40c0-8069-026751647e6d
date added to LUP
2019-12-11 12:46:16
date last changed
2021-12-01 12:20:34
@inbook{b894e3fa-222e-40c0-8069-026751647e6d,
  abstract     = {<p>Botulinum neurotoxins (BoNTs) are a family of bacterial protein toxins produced by various Clostridium species. They are traditionally classified into seven major serotypes (BoNT/A-G). Recent progress in sequencing microbial genomes has led to an ever-growing number of subtypes, chimeric toxins, BoNT-like toxins, and remotely related BoNT homologs, constituting an expanding BoNT superfamily. Recent structural studies of BoNTs, BoNT progenitor toxin complexes, tetanus neurotoxin (TeNT), toxin-receptor complexes, and toxin-substrate complexes have provided mechanistic understandings of toxin functions and the molecular basis for their variations. The growing BoNT superfamily of toxins present a natural repertoire that can be explored to develop novel therapeutic toxins, and the structural understanding of their variations provides a knowledge basis for engineering toxins to improve therapeutic efficacy and expand their clinical applications.</p>},
  author       = {Dong, Min and Stenmark, Pål},
  booktitle    = {Botulinum Toxin Therapy},
  editor       = {Whitcup, Scott M. and Hallett, Mark},
  isbn         = {978-3-030-66305-6},
  issn         = {0171-2004},
  language     = {eng},
  pages        = {11--33},
  publisher    = {Springer Nature},
  series       = {Handbook of experimental pharmacology},
  title        = {The Structure and Classification of Botulinum Toxins},
  url          = {http://dx.doi.org/10.1007/164_2019_342},
  doi          = {10.1007/164_2019_342},
  volume       = {263},
  year         = {2021},
}