Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Self-Derived Dynamic Field Map Estimation and Correction in CEST MRI

Mahmud, Sultan Z ; Ju, Kevin ; Xu, Jianping ; Knutsson, Linda LU orcid ; Zijl, Peter van and Heo, Hye-Young (2026) In Magnetic Resonance in Medicine
Abstract

PURPOSE: To demonstrate a self-derived, dynamic field map (∆B0) estimation and correction method for improved CEST measurements without additional scans, especially in the presence of subject motion.

METHODS: Dynamic ∆B0 maps were derived directly from the CEST images acquired with rosette readout trajectories by segmenting the rosette k-space data. The rosette ∆B0 mapping accuracy was validated against standard dual-echo Cartesian GRE ∆B0 maps. The utility of dynamic ∆B0 estimation and correction for CEST MRI was demonstrated in healthy volunteers at 3 T with and without the presence of motion.

RESULTS: Self-derived dynamic ∆B0 correction substantially... (More)

PURPOSE: To demonstrate a self-derived, dynamic field map (∆B0) estimation and correction method for improved CEST measurements without additional scans, especially in the presence of subject motion.

METHODS: Dynamic ∆B0 maps were derived directly from the CEST images acquired with rosette readout trajectories by segmenting the rosette k-space data. The rosette ∆B0 mapping accuracy was validated against standard dual-echo Cartesian GRE ∆B0 maps. The utility of dynamic ∆B0 estimation and correction for CEST MRI was demonstrated in healthy volunteers at 3 T with and without the presence of motion.

RESULTS: Self-derived dynamic ∆B0 correction substantially improved the CEST measurements compared to static ∆B0 correction, particularly under conditions of motion. The mean differences between the motion-free and motion-corrupted global Z-spectra were 0.23% ± 0.06% (p > 0.2) and 3.10% ± 0.70% (p < 0.03) with dynamic and static ΔB0 correction, respectively. Dynamic ΔB0-corrected APTw values in the presence of motion also showed very high correlation (R ≥ 0.96) with motion-free values, whereas static ΔB0-corrected APTw values showed very poor correlation (R ≤ 0.02).

CONCLUSION: By enabling dynamic ΔB0 mapping, rosette-CEST MRI enhances the accuracy of CEST measurements in the presence of subject motion-induced B0 fluctuations, eliminating the need for additional scans or separate alignment of ΔB0 and saturation spectra.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; and
publishing date
type
Contribution to journal
publication status
epub
subject
in
Magnetic Resonance in Medicine
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:42163000
  • scopus:105039847765
ISSN
1522-2594
DOI
10.1002/mrm.70445
language
English
LU publication?
no
additional info
© 2026 International Society for Magnetic Resonance in Medicine.
id
b8b4f20a-dfc7-4002-a824-bdc1ef42ef39
date added to LUP
2026-07-01 13:03:26
date last changed
2026-07-02 04:01:12
@article{b8b4f20a-dfc7-4002-a824-bdc1ef42ef39,
  abstract     = {{<p>PURPOSE: To demonstrate a self-derived, dynamic field map (∆B<sub>0</sub>) estimation and correction method for improved CEST measurements without additional scans, especially in the presence of subject motion. </p><p>METHODS: Dynamic ∆B<sub>0</sub> maps were derived directly from the CEST images acquired with rosette readout trajectories by segmenting the rosette k-space data. The rosette ∆B<sub>0</sub> mapping accuracy was validated against standard dual-echo Cartesian GRE ∆B<sub>0</sub> maps. The utility of dynamic ∆B<sub>0</sub> estimation and correction for CEST MRI was demonstrated in healthy volunteers at 3 T with and without the presence of motion. </p><p>RESULTS: Self-derived dynamic ∆B<sub>0</sub> correction substantially improved the CEST measurements compared to static ∆B<sub>0</sub> correction, particularly under conditions of motion. The mean differences between the motion-free and motion-corrupted global Z-spectra were 0.23% ± 0.06% (p &gt; 0.2) and 3.10% ± 0.70% (p &lt; 0.03) with dynamic and static ΔB<sub>0</sub> correction, respectively. Dynamic ΔB<sub>0</sub>-corrected APTw values in the presence of motion also showed very high correlation (R ≥ 0.96) with motion-free values, whereas static ΔB<sub>0</sub>-corrected APTw values showed very poor correlation (R ≤ 0.02). </p><p>CONCLUSION: By enabling dynamic ΔB<sub>0</sub> mapping, rosette-CEST MRI enhances the accuracy of CEST measurements in the presence of subject motion-induced B<sub>0</sub> fluctuations, eliminating the need for additional scans or separate alignment of ΔB<sub>0</sub> and saturation spectra. </p>}},
  author       = {{Mahmud, Sultan Z and Ju, Kevin and Xu, Jianping and Knutsson, Linda and Zijl, Peter van and Heo, Hye-Young}},
  issn         = {{1522-2594}},
  language     = {{eng}},
  month        = {{05}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Magnetic Resonance in Medicine}},
  title        = {{Self-Derived Dynamic Field Map Estimation and Correction in CEST MRI}},
  url          = {{http://dx.doi.org/10.1002/mrm.70445}},
  doi          = {{10.1002/mrm.70445}},
  year         = {{2026}},
}