Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Crossed over repair of the femoral sensory and motor branches influences N-CAM

Saito, Harukazu ; Kanje, Martin LU and Dahlin, Lars LU orcid (2010) In NeuroReport 21(12). p.841-845
Abstract
N-CAM, expressed by non-myelinating Schwann cells, was investigated by immunohistochemistry in transected rat femoral nerves, which were repaired either using a straight or a crossed over technique. N-CAM staining covered 30 and 11% of the cross-sectional area of and motor branches, respectively, in uninjured nerves. After 3 days there was a transient smaller area of N-CAM staining following both the repairs. After a straight repair N-CAM area increased to the control values in both branches. In contrast, a crossed over repair resulted in a continuous increase of N-CAM in the motor branch, whereas the area in the sensory branch returned slowly to control values. N-CAM is influenced by an intentionally misdirected outgrowth of motor and... (More)
N-CAM, expressed by non-myelinating Schwann cells, was investigated by immunohistochemistry in transected rat femoral nerves, which were repaired either using a straight or a crossed over technique. N-CAM staining covered 30 and 11% of the cross-sectional area of and motor branches, respectively, in uninjured nerves. After 3 days there was a transient smaller area of N-CAM staining following both the repairs. After a straight repair N-CAM area increased to the control values in both branches. In contrast, a crossed over repair resulted in a continuous increase of N-CAM in the motor branch, whereas the area in the sensory branch returned slowly to control values. N-CAM is influenced by an intentionally misdirected outgrowth of motor and sensory axons after nerve repair. NeuroReport 21:841-845 (C) 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins. (Less)
Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
neurofilaments, nerve repair, nerve regeneration, N-CAM, axons, misdirection, non-myelinating, Schwann cells
in
NeuroReport
volume
21
issue
12
pages
841 - 845
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000280592900010
  • scopus:77955231671
  • pmid:20622691
ISSN
1473-558X
DOI
10.1097/WNR.0b013e32833d40e2
language
English
LU publication?
yes
id
b8d23cd2-08c6-4014-878c-a8af286cf243 (old id 1677879)
date added to LUP
2016-04-01 09:56:04
date last changed
2023-08-30 13:37:39
@article{b8d23cd2-08c6-4014-878c-a8af286cf243,
  abstract     = {{N-CAM, expressed by non-myelinating Schwann cells, was investigated by immunohistochemistry in transected rat femoral nerves, which were repaired either using a straight or a crossed over technique. N-CAM staining covered 30 and 11% of the cross-sectional area of and motor branches, respectively, in uninjured nerves. After 3 days there was a transient smaller area of N-CAM staining following both the repairs. After a straight repair N-CAM area increased to the control values in both branches. In contrast, a crossed over repair resulted in a continuous increase of N-CAM in the motor branch, whereas the area in the sensory branch returned slowly to control values. N-CAM is influenced by an intentionally misdirected outgrowth of motor and sensory axons after nerve repair. NeuroReport 21:841-845 (C) 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.}},
  author       = {{Saito, Harukazu and Kanje, Martin and Dahlin, Lars}},
  issn         = {{1473-558X}},
  keywords     = {{neurofilaments; nerve repair; nerve regeneration; N-CAM; axons; misdirection; non-myelinating; Schwann cells}},
  language     = {{eng}},
  number       = {{12}},
  pages        = {{841--845}},
  publisher    = {{Lippincott Williams & Wilkins}},
  series       = {{NeuroReport}},
  title        = {{Crossed over repair of the femoral sensory and motor branches influences N-CAM}},
  url          = {{http://dx.doi.org/10.1097/WNR.0b013e32833d40e2}},
  doi          = {{10.1097/WNR.0b013e32833d40e2}},
  volume       = {{21}},
  year         = {{2010}},
}