Complement deficiency states and associated infections.
(2011) In Molecular Immunology 48. p.1643-1655- Abstract
- A major function of the immune system is to protect the host from microbial infections. The complement system plays important roles in both the innate and the adaptive immune defense and also acts as a bridge between these arms of immunity. This is obvious from complement deficiencies which in varying degree, depending on which factor is missing, are associated with increased infection susceptibility and also increased risk for other, mainly autoimmune diseases. Genetically determined deficiencies are described for almost all complement proteins but the consequences show a wide variation. Here the genetic defects and molecular abnormalities in complement deficient persons, related clinically relevant infections and the options for... (More)
- A major function of the immune system is to protect the host from microbial infections. The complement system plays important roles in both the innate and the adaptive immune defense and also acts as a bridge between these arms of immunity. This is obvious from complement deficiencies which in varying degree, depending on which factor is missing, are associated with increased infection susceptibility and also increased risk for other, mainly autoimmune diseases. Genetically determined deficiencies are described for almost all complement proteins but the consequences show a wide variation. Here the genetic defects and molecular abnormalities in complement deficient persons, related clinically relevant infections and the options for prevention and therapy are reviewed. The roles of complement in host defense against common infections are also discussed. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2008690
- author
- Melander Skattum, Lillemor LU ; van Deuren, Marcel ; van der Poll, Tom and Truedsson, Lennart LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Molecular Immunology
- volume
- 48
- pages
- 1643 - 1655
- publisher
- Pergamon Press Ltd.
- external identifiers
-
- wos:000294096100007
- pmid:21624663
- scopus:79960452978
- ISSN
- 1872-9142
- DOI
- 10.1016/j.molimm.2011.05.001
- language
- English
- LU publication?
- yes
- id
- b8e3d045-f0c5-4e68-8ade-f4d0e8a87cff (old id 2008690)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21624663?dopt=Abstract
- date added to LUP
- 2016-04-04 09:36:20
- date last changed
- 2022-02-21 01:36:04
@article{b8e3d045-f0c5-4e68-8ade-f4d0e8a87cff,
abstract = {{A major function of the immune system is to protect the host from microbial infections. The complement system plays important roles in both the innate and the adaptive immune defense and also acts as a bridge between these arms of immunity. This is obvious from complement deficiencies which in varying degree, depending on which factor is missing, are associated with increased infection susceptibility and also increased risk for other, mainly autoimmune diseases. Genetically determined deficiencies are described for almost all complement proteins but the consequences show a wide variation. Here the genetic defects and molecular abnormalities in complement deficient persons, related clinically relevant infections and the options for prevention and therapy are reviewed. The roles of complement in host defense against common infections are also discussed.}},
author = {{Melander Skattum, Lillemor and van Deuren, Marcel and van der Poll, Tom and Truedsson, Lennart}},
issn = {{1872-9142}},
language = {{eng}},
pages = {{1643--1655}},
publisher = {{Pergamon Press Ltd.}},
series = {{Molecular Immunology}},
title = {{Complement deficiency states and associated infections.}},
url = {{http://dx.doi.org/10.1016/j.molimm.2011.05.001}},
doi = {{10.1016/j.molimm.2011.05.001}},
volume = {{48}},
year = {{2011}},
}