Enteral leptin administration affects intestinal autophagy in suckling piglets
(2014) In Domestic Animal Endocrinology 46. p.12-19- Abstract
- Leptin has been shown to play an integral role in the endocrine regulation of metabolism. Moreover, a substantial amount of this peptide has been found in colostrum and milk. The aim of the study was to investigate the effects of exogenous leptin, administered intragastrically, on the process of autophagy and the changes in cell hyperplasia and hypertrophy in the small intestine mucosa. Three groups (n = 6) of neonatal piglets were used in the study. The pigs were fed either by their sows (sow-reared piglets) or with only milk formula, or with milk formula together with leptin administered via a stomach tube (10 mu g/kg BW) every 8 h for 6 d. We have shown that pure milk formula feeding significantly elevates (P < 0.05) autophagy... (More)
- Leptin has been shown to play an integral role in the endocrine regulation of metabolism. Moreover, a substantial amount of this peptide has been found in colostrum and milk. The aim of the study was to investigate the effects of exogenous leptin, administered intragastrically, on the process of autophagy and the changes in cell hyperplasia and hypertrophy in the small intestine mucosa. Three groups (n = 6) of neonatal piglets were used in the study. The pigs were fed either by their sows (sow-reared piglets) or with only milk formula, or with milk formula together with leptin administered via a stomach tube (10 mu g/kg BW) every 8 h for 6 d. We have shown that pure milk formula feeding significantly elevates (P < 0.05) autophagy compared with that observed in sow-reared piglets. Compared with the control group, feeding milk formula supplemented with leptin resulted in a significant decrease (P < 0.05) in immunodetection of microtubule-associated protein 1 light chain 3, as well as significantly accelerated epithelial cell renewal (P < 0.05). We demonstrated that autophagy is involved in the remodeling of the small intestine mucosa and that leptin, when administered enterally, may be an important factor for its regulation. (C) 2014 Elsevier Inc. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4319104
- author
- Slupecka, M. ; Wolinski, J. ; Gajewska, M. and Pierzynowski, Stefan LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Leptin, Intestine, Autophagy, Pig
- in
- Domestic Animal Endocrinology
- volume
- 46
- pages
- 12 - 19
- publisher
- Elsevier
- external identifiers
-
- wos:000329957900002
- scopus:84892371654
- pmid:24135555
- ISSN
- 0739-7240
- DOI
- 10.1016/j.domaniend.2013.09.007
- language
- English
- LU publication?
- yes
- id
- ba0658b2-417e-43dc-80db-b6195758958c (old id 4319104)
- date added to LUP
- 2016-04-01 13:45:43
- date last changed
- 2022-03-14 01:48:29
@article{ba0658b2-417e-43dc-80db-b6195758958c,
abstract = {{Leptin has been shown to play an integral role in the endocrine regulation of metabolism. Moreover, a substantial amount of this peptide has been found in colostrum and milk. The aim of the study was to investigate the effects of exogenous leptin, administered intragastrically, on the process of autophagy and the changes in cell hyperplasia and hypertrophy in the small intestine mucosa. Three groups (n = 6) of neonatal piglets were used in the study. The pigs were fed either by their sows (sow-reared piglets) or with only milk formula, or with milk formula together with leptin administered via a stomach tube (10 mu g/kg BW) every 8 h for 6 d. We have shown that pure milk formula feeding significantly elevates (P < 0.05) autophagy compared with that observed in sow-reared piglets. Compared with the control group, feeding milk formula supplemented with leptin resulted in a significant decrease (P < 0.05) in immunodetection of microtubule-associated protein 1 light chain 3, as well as significantly accelerated epithelial cell renewal (P < 0.05). We demonstrated that autophagy is involved in the remodeling of the small intestine mucosa and that leptin, when administered enterally, may be an important factor for its regulation. (C) 2014 Elsevier Inc. All rights reserved.}},
author = {{Slupecka, M. and Wolinski, J. and Gajewska, M. and Pierzynowski, Stefan}},
issn = {{0739-7240}},
keywords = {{Leptin; Intestine; Autophagy; Pig}},
language = {{eng}},
pages = {{12--19}},
publisher = {{Elsevier}},
series = {{Domestic Animal Endocrinology}},
title = {{Enteral leptin administration affects intestinal autophagy in suckling piglets}},
url = {{http://dx.doi.org/10.1016/j.domaniend.2013.09.007}},
doi = {{10.1016/j.domaniend.2013.09.007}},
volume = {{46}},
year = {{2014}},
}