Staging of Lewy-related pathology in dementia
(2012) In Clinical Neuropathology 31(4). p.216-223- Abstract
- Objective: Lewy-related pathology is the characteristic feature of Parkinson's disease with and without dementia and dementia with Lewy bodies (DLB). There are two neuropathological staging systems for Lewy-related pathology commonly employed today: the staging system for Parkinson-related pathology by Braak et al., and the staging system by the Consortium on DLB. There are also several modified systems based on these two scales. Methods: We applied a total of eight different staging systems for Lewy-related pathology to 36 consecutive demented patients with various dementia disorders. Results: The staging systems varied considerably in number of unclassifiable cases (range 0 - 16 out of 36 cases), while the diagnostic agreement between... (More)
- Objective: Lewy-related pathology is the characteristic feature of Parkinson's disease with and without dementia and dementia with Lewy bodies (DLB). There are two neuropathological staging systems for Lewy-related pathology commonly employed today: the staging system for Parkinson-related pathology by Braak et al., and the staging system by the Consortium on DLB. There are also several modified systems based on these two scales. Methods: We applied a total of eight different staging systems for Lewy-related pathology to 36 consecutive demented patients with various dementia disorders. Results: The staging systems varied considerably in number of unclassifiable cases (range 0 - 16 out of 36 cases), while the diagnostic agreement between the systems that were able to classify all or the very majority of cases varied only slightly (weighted kappa 0.86 - 0.92 and Spearman's sigma 0.80 - 1.0). Conclusion: The different staging systems for Lewy-related pathology that exist today vary in staging procedure and proportion of unclassifiable cases. The choice of system may affect the stage of Lewy-related pathology and ultimately final diagnosis. (Less)
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https://lup.lub.lu.se/record/2979341
- author
- Brunnström, Hans LU ; Lindberg, Eva and Englund, Elisabet LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Lewy body, Lewy body disease, neuropathology, Parkinson's disease
- in
- Clinical Neuropathology
- volume
- 31
- issue
- 4
- pages
- 216 - 223
- publisher
- Dustri-Verlag
- external identifiers
-
- wos:000306575700004
- scopus:84864122260
- pmid:22541783
- ISSN
- 0722-5091
- DOI
- 10.5414/NP300471
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000)
- id
- ba599498-6fcd-4d97-a084-623deaa55457 (old id 2979341)
- date added to LUP
- 2016-04-01 14:03:05
- date last changed
- 2022-01-27 22:33:37
@article{ba599498-6fcd-4d97-a084-623deaa55457, abstract = {{Objective: Lewy-related pathology is the characteristic feature of Parkinson's disease with and without dementia and dementia with Lewy bodies (DLB). There are two neuropathological staging systems for Lewy-related pathology commonly employed today: the staging system for Parkinson-related pathology by Braak et al., and the staging system by the Consortium on DLB. There are also several modified systems based on these two scales. Methods: We applied a total of eight different staging systems for Lewy-related pathology to 36 consecutive demented patients with various dementia disorders. Results: The staging systems varied considerably in number of unclassifiable cases (range 0 - 16 out of 36 cases), while the diagnostic agreement between the systems that were able to classify all or the very majority of cases varied only slightly (weighted kappa 0.86 - 0.92 and Spearman's sigma 0.80 - 1.0). Conclusion: The different staging systems for Lewy-related pathology that exist today vary in staging procedure and proportion of unclassifiable cases. The choice of system may affect the stage of Lewy-related pathology and ultimately final diagnosis.}}, author = {{Brunnström, Hans and Lindberg, Eva and Englund, Elisabet}}, issn = {{0722-5091}}, keywords = {{Lewy body; Lewy body disease; neuropathology; Parkinson's disease}}, language = {{eng}}, number = {{4}}, pages = {{216--223}}, publisher = {{Dustri-Verlag}}, series = {{Clinical Neuropathology}}, title = {{Staging of Lewy-related pathology in dementia}}, url = {{http://dx.doi.org/10.5414/NP300471}}, doi = {{10.5414/NP300471}}, volume = {{31}}, year = {{2012}}, }