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The Use of Central Nervous System Active Drugs During Pregnancy.

Källén, Bengt LU ; Borg, Natalia and Reis, Margareta LU (2013) In Pharmaceuticals 6(10). p.1221-1286
Abstract
CNS-active drugs are used relatively often during pregnancy. Use during early pregnancy may increase the risk of a congenital malformation; use during the later part of pregnancy may be associated with preterm birth, intrauterine growth disturbances and neonatal morbidity. There is also a possibility that drug exposure can affect brain development with long-term neuropsychological harm as a result. This paper summarizes the literature on such drugs used during pregnancy: opioids, anticonvulsants, drugs used for Parkinson's disease, neuroleptics, sedatives and hypnotics, antidepressants, psychostimulants, and some other CNS-active drugs. In addition to an overview of the literature, data from the Swedish Medical Birth Register (1996-2011)... (More)
CNS-active drugs are used relatively often during pregnancy. Use during early pregnancy may increase the risk of a congenital malformation; use during the later part of pregnancy may be associated with preterm birth, intrauterine growth disturbances and neonatal morbidity. There is also a possibility that drug exposure can affect brain development with long-term neuropsychological harm as a result. This paper summarizes the literature on such drugs used during pregnancy: opioids, anticonvulsants, drugs used for Parkinson's disease, neuroleptics, sedatives and hypnotics, antidepressants, psychostimulants, and some other CNS-active drugs. In addition to an overview of the literature, data from the Swedish Medical Birth Register (1996-2011) are presented. The exposure data are either based on midwife interviews towards the end of the first trimester or on linkage with a prescribed drug register. An association between malformations and maternal use of anticonvulsants and notably valproic acid is well known from the literature and also demonstrated in the present study. Some other associations between drug exposure and outcome were found. (Less)
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author
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organization
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type
Contribution to journal
publication status
published
subject
in
Pharmaceuticals
volume
6
issue
10
pages
1221 - 1286
publisher
MDPI AG
external identifiers
  • pmid:24275849
  • scopus:84885641016
  • pmid:24275849
ISSN
1424-8247
DOI
10.3390/ph6101221
language
English
LU publication?
yes
id
ba7224c2-eae8-4c22-8931-3b9e6ed0b738 (old id 4178927)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24275849?dopt=Abstract
date added to LUP
2016-04-01 14:44:12
date last changed
2020-10-04 05:53:45
@article{ba7224c2-eae8-4c22-8931-3b9e6ed0b738,
  abstract     = {CNS-active drugs are used relatively often during pregnancy. Use during early pregnancy may increase the risk of a congenital malformation; use during the later part of pregnancy may be associated with preterm birth, intrauterine growth disturbances and neonatal morbidity. There is also a possibility that drug exposure can affect brain development with long-term neuropsychological harm as a result. This paper summarizes the literature on such drugs used during pregnancy: opioids, anticonvulsants, drugs used for Parkinson's disease, neuroleptics, sedatives and hypnotics, antidepressants, psychostimulants, and some other CNS-active drugs. In addition to an overview of the literature, data from the Swedish Medical Birth Register (1996-2011) are presented. The exposure data are either based on midwife interviews towards the end of the first trimester or on linkage with a prescribed drug register. An association between malformations and maternal use of anticonvulsants and notably valproic acid is well known from the literature and also demonstrated in the present study. Some other associations between drug exposure and outcome were found.},
  author       = {Källén, Bengt and Borg, Natalia and Reis, Margareta},
  issn         = {1424-8247},
  language     = {eng},
  number       = {10},
  pages        = {1221--1286},
  publisher    = {MDPI AG},
  series       = {Pharmaceuticals},
  title        = {The Use of Central Nervous System Active Drugs During Pregnancy.},
  url          = {https://lup.lub.lu.se/search/ws/files/4135330/4423180.pdf},
  doi          = {10.3390/ph6101221},
  volume       = {6},
  year         = {2013},
}