Insulin-like growth factor-1 in relation to adult weight and birth weight in healthy nulliparous women
Jernström, H LU and Olsson, H LU
(1998)
In International Journal of Gynecology & Obstetrics
62(1).
p.8-11
- Abstract
OBJECTIVE: To study the relationships between plasma insulin-like growth factor-1 (IGF-1) concentrations and birth weight, current weight and other constitutional factors among healthy, nulliparous women aged 19-25 years.
DESIGN AND METHODS: Forty healthy female university students aged 19-25 years volunteered for this study. They had never been pregnant and were not using oral contraceptives (OCs). Blood samples were drawn both in the follicular and luteal cycle phases (08:00-10:00 h) and weight, height, and waist-hip ratio were measured at the same time by one person (H.J). Information regarding age, birth weight, OC use, etc. was obtained from a questionnaire filled out by the women. Plasma IGF-1 concentrations were analyzed by... (More)
OBJECTIVE: To study the relationships between plasma insulin-like growth factor-1 (IGF-1) concentrations and birth weight, current weight and other constitutional factors among healthy, nulliparous women aged 19-25 years.
DESIGN AND METHODS: Forty healthy female university students aged 19-25 years volunteered for this study. They had never been pregnant and were not using oral contraceptives (OCs). Blood samples were drawn both in the follicular and luteal cycle phases (08:00-10:00 h) and weight, height, and waist-hip ratio were measured at the same time by one person (H.J). Information regarding age, birth weight, OC use, etc. was obtained from a questionnaire filled out by the women. Plasma IGF-1 concentrations were analyzed by radio immunoassay.
RESULTS: In a multivariate model including birth weight, current weight and age, IGF-1 was significantly inversely associated with birth weight in both cycle phases, while current weight was positively associated with IGF-1 in both cycle phases although only significantly so in the follicular phase. IGF-1 concentrations in both cycle phases showed a non-significant decrease with age.
CONCLUSION: In this group of 19-25-year-old healthy nulliparous women IGF-1 displayed a significant inverse association with birth weight in both cycle phases given that the current weight was adjusted for, while current weight was positively related to IGF-1 concentrations.
(Less)
- author
- Jernström, H
LU
and Olsson, H
LU
- publishing date
- 1998-07
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Adult, Birth Weight, Body Weight, Female, Follicular Phase, Humans, Insulin-Like Growth Factor I, Luteal Phase, Multivariate Analysis
- in
- International Journal of Gynecology & Obstetrics
- volume
- 62
- issue
- 1
- pages
- 8 pages
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:9722119
- scopus:0031855602
- pmid:9722119
- ISSN
- 1879-3479
- DOI
- 10.1016/S0020-7292(98)00060-5
- language
- English
- LU publication?
- no
- id
- ba7f9432-732f-4057-b338-7b9ce375e286 (old id 1112995)
- date added to LUP
- 2016-04-01 11:36:32
- date last changed
- 2022-01-26 07:32:00
@article{ba7f9432-732f-4057-b338-7b9ce375e286,
abstract = {{<p>OBJECTIVE: To study the relationships between plasma insulin-like growth factor-1 (IGF-1) concentrations and birth weight, current weight and other constitutional factors among healthy, nulliparous women aged 19-25 years.</p><p>DESIGN AND METHODS: Forty healthy female university students aged 19-25 years volunteered for this study. They had never been pregnant and were not using oral contraceptives (OCs). Blood samples were drawn both in the follicular and luteal cycle phases (08:00-10:00 h) and weight, height, and waist-hip ratio were measured at the same time by one person (H.J). Information regarding age, birth weight, OC use, etc. was obtained from a questionnaire filled out by the women. Plasma IGF-1 concentrations were analyzed by radio immunoassay.</p><p>RESULTS: In a multivariate model including birth weight, current weight and age, IGF-1 was significantly inversely associated with birth weight in both cycle phases, while current weight was positively associated with IGF-1 in both cycle phases although only significantly so in the follicular phase. IGF-1 concentrations in both cycle phases showed a non-significant decrease with age.</p><p>CONCLUSION: In this group of 19-25-year-old healthy nulliparous women IGF-1 displayed a significant inverse association with birth weight in both cycle phases given that the current weight was adjusted for, while current weight was positively related to IGF-1 concentrations.</p>}},
author = {{Jernström, H and Olsson, H}},
issn = {{1879-3479}},
keywords = {{Adult; Birth Weight; Body Weight; Female; Follicular Phase; Humans; Insulin-Like Growth Factor I; Luteal Phase; Multivariate Analysis}},
language = {{eng}},
number = {{1}},
pages = {{8--11}},
publisher = {{Wiley-Blackwell}},
series = {{International Journal of Gynecology & Obstetrics}},
title = {{Insulin-like growth factor-1 in relation to adult weight and birth weight in healthy nulliparous women}},
url = {{http://dx.doi.org/10.1016/S0020-7292(98)00060-5}},
doi = {{10.1016/S0020-7292(98)00060-5}},
volume = {{62}},
year = {{1998}},
}