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Minor alterations in the intestinal microbiota composition upon Rotavirus infection do not affect susceptibility to DSS colitis

Hamza, Kedir Hussen LU ; Dunér, Emma ; Ulmert, Isabel LU ; Arias, Armando ; Sorobetea, Daniel LU and Lahl, Katharina LU (2021) In Scientific Reports 11(1).
Abstract

Viral triggers at the intestinal mucosa can have multiple global effects on intestinal integrity, causing elevated intestinal barrier strength and relative protection from subsequent inflammatory bowel disease (IBD) induction in various models. As viruses can interfere with the intestinal immune system both directly and indirectly through commensal bacteria, cause-effect relationships are difficult to define. Due to the complexity of putatively causative factors, our understanding of such virus-mediated protection is currently very limited. We here set out to better understand the impact that adult enteric infection with rotavirus (RV) might have on the composition of the intestinal microbiome and on the severity of IBD. We found that... (More)

Viral triggers at the intestinal mucosa can have multiple global effects on intestinal integrity, causing elevated intestinal barrier strength and relative protection from subsequent inflammatory bowel disease (IBD) induction in various models. As viruses can interfere with the intestinal immune system both directly and indirectly through commensal bacteria, cause-effect relationships are difficult to define. Due to the complexity of putatively causative factors, our understanding of such virus-mediated protection is currently very limited. We here set out to better understand the impact that adult enteric infection with rotavirus (RV) might have on the composition of the intestinal microbiome and on the severity of IBD. We found that RV infection neither induced significant long-lasting microbiota community changes in the small or large intestine nor affected the severity of subsequent dextran sulfate sodium-induced colitis. Hence, adult murine RV infection does not exert lasting effects on intestinal homeostasis.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scientific Reports
volume
11
issue
1
article number
13485
pages
11 pages
publisher
Nature Publishing Group
external identifiers
  • scopus:85110053676
  • pmid:34188111
ISSN
2045-2322
DOI
10.1038/s41598-021-92796-7
language
English
LU publication?
yes
additional info
Copyright: This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine
id
ba8b8075-e680-4002-a385-59b5208c5dec
date added to LUP
2021-09-06 18:44:32
date last changed
2024-06-16 18:28:45
@article{ba8b8075-e680-4002-a385-59b5208c5dec,
  abstract     = {{<p>Viral triggers at the intestinal mucosa can have multiple global effects on intestinal integrity, causing elevated intestinal barrier strength and relative protection from subsequent inflammatory bowel disease (IBD) induction in various models. As viruses can interfere with the intestinal immune system both directly and indirectly through commensal bacteria, cause-effect relationships are difficult to define. Due to the complexity of putatively causative factors, our understanding of such virus-mediated protection is currently very limited. We here set out to better understand the impact that adult enteric infection with rotavirus (RV) might have on the composition of the intestinal microbiome and on the severity of IBD. We found that RV infection neither induced significant long-lasting microbiota community changes in the small or large intestine nor affected the severity of subsequent dextran sulfate sodium-induced colitis. Hence, adult murine RV infection does not exert lasting effects on intestinal homeostasis.</p>}},
  author       = {{Hamza, Kedir Hussen and Dunér, Emma and Ulmert, Isabel and Arias, Armando and Sorobetea, Daniel and Lahl, Katharina}},
  issn         = {{2045-2322}},
  language     = {{eng}},
  month        = {{06}},
  number       = {{1}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Scientific Reports}},
  title        = {{Minor alterations in the intestinal microbiota composition upon Rotavirus infection do not affect susceptibility to DSS colitis}},
  url          = {{http://dx.doi.org/10.1038/s41598-021-92796-7}},
  doi          = {{10.1038/s41598-021-92796-7}},
  volume       = {{11}},
  year         = {{2021}},
}