Current approaches to measuring human islet-antigen specific T cell function in type 1 diabetes.
(2010) In Clinical and Experimental Immunology okt. p.197-209- Abstract
- Type 1 diabetes (T1D) is an autoimmune disease caused by the T cell-mediated destruction of the pancreatic insulin-producing beta cells. Currently there are no widely accepted and standardized assays available to analyse the function of autoreactive T cells involved in T1D. The development of such an assay would greatly aid efforts to understand the pathogenesis of T1D and is also urgently required to guide the development of antigen-based therapies intended to prevent, or cure, T1D. Here we describe some of the assays used currently to detect autoreactive T cells in human blood and review critically their strengths and weaknesses. The challenges and future prospects for the T cell assays are discussed.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1688166
- author
- Mannering, S I ; Wong, F S ; Durinovic-Belló, I ; Brooks-Worrell, B ; Tree, T I ; Cilio, Corrado LU ; Schloot, N C and Mallone, R
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Clinical and Experimental Immunology
- volume
- okt
- pages
- 197 - 209
- publisher
- British Society for Immunology
- external identifiers
-
- wos:000282694800001
- pmid:20846160
- scopus:78649358914
- ISSN
- 0009-9104
- DOI
- 10.1111/j.1365-2249.2010.04237.x
- language
- English
- LU publication?
- yes
- id
- bab634ab-27c0-40be-a5e7-d972fb55936a (old id 1688166)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/20846160?dopt=Abstract
- date added to LUP
- 2016-04-04 08:46:23
- date last changed
- 2022-01-29 03:59:04
@article{bab634ab-27c0-40be-a5e7-d972fb55936a,
abstract = {{Type 1 diabetes (T1D) is an autoimmune disease caused by the T cell-mediated destruction of the pancreatic insulin-producing beta cells. Currently there are no widely accepted and standardized assays available to analyse the function of autoreactive T cells involved in T1D. The development of such an assay would greatly aid efforts to understand the pathogenesis of T1D and is also urgently required to guide the development of antigen-based therapies intended to prevent, or cure, T1D. Here we describe some of the assays used currently to detect autoreactive T cells in human blood and review critically their strengths and weaknesses. The challenges and future prospects for the T cell assays are discussed.}},
author = {{Mannering, S I and Wong, F S and Durinovic-Belló, I and Brooks-Worrell, B and Tree, T I and Cilio, Corrado and Schloot, N C and Mallone, R}},
issn = {{0009-9104}},
language = {{eng}},
pages = {{197--209}},
publisher = {{British Society for Immunology}},
series = {{Clinical and Experimental Immunology}},
title = {{Current approaches to measuring human islet-antigen specific T cell function in type 1 diabetes.}},
url = {{http://dx.doi.org/10.1111/j.1365-2249.2010.04237.x}},
doi = {{10.1111/j.1365-2249.2010.04237.x}},
volume = {{okt}},
year = {{2010}},
}