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Genetic Predisposition to Multiple Myeloma at 5q15 Is Mediated by an ELL2 Enhancer Polymorphism

Li, Ni L.; Johnson, David C.; Weinhold, Niels; Kimber, Scott; Dobbins, Sara E.; Mitchell, Jonathan S; Kinnersley, Ben; Sud, Amit LU ; Law, Philip J. and Orlando, Giulia, et al. (2017) In Cell Reports 20(11). p.2556-2564
Abstract

Multiple myeloma (MM) is a malignancy of plasma cells. Genome-wide association studies have shown that variation at 5q15 influences MM risk. Here, we have sought to decipher the causal variant at 5q15 and the mechanism by which it influences tumorigenesis. We show that rs6877329 G > C resides in a predicted enhancer element that physically interacts with the transcription start site of ELL2. The rs6877329-C risk allele is associated with reduced enhancer activity and lowered ELL2 expression. Since ELL2 is critical to the B cell differentiation process, reduced ELL2 expression is consistent with inherited genetic variation contributing to arrest of plasma cell development, facilitating MM clonal expansion. These data provide evidence... (More)

Multiple myeloma (MM) is a malignancy of plasma cells. Genome-wide association studies have shown that variation at 5q15 influences MM risk. Here, we have sought to decipher the causal variant at 5q15 and the mechanism by which it influences tumorigenesis. We show that rs6877329 G > C resides in a predicted enhancer element that physically interacts with the transcription start site of ELL2. The rs6877329-C risk allele is associated with reduced enhancer activity and lowered ELL2 expression. Since ELL2 is critical to the B cell differentiation process, reduced ELL2 expression is consistent with inherited genetic variation contributing to arrest of plasma cell development, facilitating MM clonal expansion. These data provide evidence for a biological mechanism underlying a hereditary risk of MM at 5q15.

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publication status
published
subject
keywords
cancer genetics, genome-wide association studies, multiple myeloma, single nucleotide polymorphisms
in
Cell Reports
volume
20
issue
11
pages
9 pages
publisher
Cell Press
external identifiers
  • scopus:85029369362
  • wos:000410377400004
ISSN
2211-1247
DOI
10.1016/j.celrep.2017.08.062
language
English
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yes
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bab8d70a-7ca0-48b5-9150-7961e61ba8b3
date added to LUP
2017-10-02 10:45:50
date last changed
2018-02-25 04:19:40
@article{bab8d70a-7ca0-48b5-9150-7961e61ba8b3,
  abstract     = {<p>Multiple myeloma (MM) is a malignancy of plasma cells. Genome-wide association studies have shown that variation at 5q15 influences MM risk. Here, we have sought to decipher the causal variant at 5q15 and the mechanism by which it influences tumorigenesis. We show that rs6877329 G &gt; C resides in a predicted enhancer element that physically interacts with the transcription start site of ELL2. The rs6877329-C risk allele is associated with reduced enhancer activity and lowered ELL2 expression. Since ELL2 is critical to the B cell differentiation process, reduced ELL2 expression is consistent with inherited genetic variation contributing to arrest of plasma cell development, facilitating MM clonal expansion. These data provide evidence for a biological mechanism underlying a hereditary risk of MM at 5q15.</p>},
  author       = {Li, Ni L. and Johnson, David C. and Weinhold, Niels and Kimber, Scott and Dobbins, Sara E. and Mitchell, Jonathan S and Kinnersley, Ben and Sud, Amit and Law, Philip J. and Orlando, Giulia and Scales, Matthew and Wardell, Christopher P. and Försti, Asta and Hoang, Phuc H. and Went, Molly and Holroyd, Amy and Hariri, Fadi and Pastinen, Tomi and Meissner, Tobias and Goldschmidt, Hartmut and Hemminki, Kari and Morgan, Gareth J and Kaiser, Martin and Houlston, Richard S.},
  issn         = {2211-1247},
  keyword      = {cancer genetics,genome-wide association studies,multiple myeloma,single nucleotide polymorphisms},
  language     = {eng},
  month        = {09},
  number       = {11},
  pages        = {2556--2564},
  publisher    = {Cell Press},
  series       = {Cell Reports},
  title        = {Genetic Predisposition to Multiple Myeloma at 5q15 Is Mediated by an ELL2 Enhancer Polymorphism},
  url          = {http://dx.doi.org/10.1016/j.celrep.2017.08.062},
  volume       = {20},
  year         = {2017},
}